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Lactobacillus plantarum BFA-LA04 strain with uric acid reducing capacity and application thereof

A BFA-LA04, Lactobacillus germinal technology, applied in medical preparations containing active ingredients, bacteria, microorganism-based methods, etc., can solve problems such as probenecid ineffectiveness, uric acid nephropathy, adverse drug reactions, etc.

Active Publication Date: 2021-10-12
KANG PIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the incidence of side effects of allopurinol is low, but some patients will have fatal serious adverse drug reactions to allopurinol, and when the patient's creatinine clearance rate (CCR) is too low, probenecid will lose Effectiveness, and there will be risk of urinary tract stones and uric acid nephropathy

Method used

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  • Lactobacillus plantarum BFA-LA04 strain with uric acid reducing capacity and application thereof
  • Lactobacillus plantarum BFA-LA04 strain with uric acid reducing capacity and application thereof
  • Lactobacillus plantarum BFA-LA04 strain with uric acid reducing capacity and application thereof

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Embodiment Construction

[0021] In order to make the above-mentioned and other objects, features and advantages of the present invention more comprehensible, the preferred embodiments of the present invention are listed below, together with the accompanying drawings, as follows:

[0022] The Lactobacillus plantarum BFA-LA04 strain of the present invention can decompose xanthine, and can also inhibit the activity of xanthine oxidase, thereby inhibiting the generation of uric acid, so it can be used as a drug for hyperuricemia.

[0023] The Lactobacillus plantarum BFA-LA04 strain is obtained from muskmelon fruit. Specifically, after the muskmelon fruit is squeezed, the muskmelon fruit juice is coated on MRS solid medium containing calcium carbonate (the formula is shown in Table 1. ), after selecting a single colony, the Lactobacillus plantarum BFA-LA04 strain was further screened out therefrom. The Lactobacillus plantarum BFA-LA04 strain has been deposited in the NITE Patent Microorganisms Depository (...

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Abstract

The invention provides a lactobacillus plantarum BFA-LA04 strain, and the lactobacillus plantarum BFA-LA04 strain has the capability of reducing uric acid; the lactobacillus plantarum BFA-LA04 strain has a 16S rDNA gene sequence as shown in SEQ ID NO: 1 and a clpP gene sequence as shown in SEQ ID NO: 2, and the lactobacillus plantarum BFA-LA04 strain is deposited at NITE Patent Microorganisms Depositary (NPMD) of Japan with a deposit number NITE BP-03110. The invention further relates to an application of the lactobacillus plantarum BFA-LA04 strain.

Description

technical field [0001] The present invention relates to a Lactobacillus plantarum strain, especially a Lactobacillus plantarum BFA-LA04 strain capable of reducing uric acid, and the present invention also relates to the use of the Lactobacillus plantarum BFA-LA04 strain. Background technique [0002] Uric acid is a heterocyclic compound containing carbon, nitrogen, oxygen and hydrogen. It is a product of the metabolic breakdown of purine nucleotides and can be excreted through urine. [0003] If uric acid cannot be excreted normally, it will flow to the connective tissue through the blood and deposit in the joints, capillaries, skin and other tissues in the form of needle-like crystals. As a foreign substance, swallow these needle-like crystals and cause local inflammatory reaction, which is gout (gout). Generally speaking, excessive concentration of uric acid in the blood (i.e. hyperuricemia) is the main cause of gout, and excessive concentration of uric acid may lead to d...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/747A61P19/06C12R1/225
CPCA61K35/747A61P19/06
Inventor 陈福安宋君哲
Owner KANG PIN TECH CO LTD
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