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Curcumin nano micelle eye drops as well as preparation method and application

A technology of nano micelles and curcumin, applied in the field of medicine, can solve the problems of restricting development and application, low bioavailability, unstable properties, etc., and achieve the effects of reducing the risk of medication, high bioavailability, and less dosage.

Inactive Publication Date: 2015-05-27
GUANGZHOU BAIEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main chain of curcumin is an unsaturated aliphatic and aromatic group, which has poor water solubility, unstable properties, rapid metabolism in the body, and low bioavailability, which seriously restricts its development and application.

Method used

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  • Curcumin nano micelle eye drops as well as preparation method and application
  • Curcumin nano micelle eye drops as well as preparation method and application
  • Curcumin nano micelle eye drops as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preparation of 0.005% curcumin nanomicelle eye drops.

[0039]

[0040]Preparation method: Weigh 0.005g of curcumin and 0.01g of chitosan nanomicelle drug carrier, put them into the grinding jar, close it after mixing, lock it on the grinder, and grind for 1 hour at 500rpm; open the grinding jar, add Tween 80 0.015g, turn off, grind for 1 hour under the same conditions; open the grinding tank, add 0.015g of propylene glycol, turn off, grind for 1 hour under the same conditions, add a small amount of medicinal pure water to wash, add to 100mL, filter with a microporous membrane , Bottled, that is.

Embodiment 2

[0041] Example 2: Preparation of 0.02% Curcumin Nanomicelle Eye Drops.

[0042]

[0043] Preparation method: Weigh 0.02g of curcumin and 0.1g of chitosan nano-micelle drug carrier, put them into the grinding jar, close them after mixing, lock them on the grinder, and grind for 1 hour at 500rpm; open the grinding jar, add Poloxamer 0.15g, turn off, grind for 1 hour under the same conditions; open the grinding tank, add 0.15g of ethanol, turn off, grind for 1 hour under the same conditions, add a small amount of medicinal pure water to wash, add to 100mL, microporous membrane Filter, bottle, and get ready.

Embodiment 3

[0044] Embodiment 3: Preparation of 0.01% curcumin nano-micelle eye drops.

[0045]

[0046] Preparation method: Weigh 0.01g of curcumin and 0.05g of chitosan nano-micelle drug carrier, put them into the grinding jar, close it after mixing, lock it on the grinder, and grind for 1 hour at 500rpm; open the grinding jar, add Sucrose fatty acid ester 0.075g, close, grind for 1 hour under the same conditions; open the grinding tank, add polyethylene glycol 0.075g, close, grind for 1 hour under the same conditions, add a small amount of medicinal pure water to wash, add to 100mL, slightly Pore ​​membrane filtration, bottling, that is.

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PUM

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Abstract

The invention provides curcumin nano micelle eye drops. The curcumin nano micelle eye drops comprise curcuminoid, a chitosan nano micelle drug carrier, a surfactant, a co-surfactant and medical pure water, wherein the mass volume percentage of curcuminoid is 0.005-0.02% and the mass volume percentage of the chitosan nano micelle drug carrier is 0.01-0.1%. The curcumin nano micelle eye drops provided by the invention are good in stability, high in bioavailability and low dosage.

Description

technical field [0001] The invention relates to the technical field of medicines, and mainly relates to an eye drop, in particular to an eye drop containing curcumin medicine, which can be used to prevent and treat eye diseases such as visual fatigue, cataract, retinopathy and the like. Background technique [0002] Eyes are organs that receive light and form images in the brain. They are delicate, complex and sensitive, enabling humans to obtain correct information in complex environments. Due to poor eye habits or degeneration of eye functions, various ophthalmic diseases are often prone to occur, which directly affect the patient's health status and behavioral ability. [0003] Various eye disorders including disorders of the front of the eye and the back of the eye, such as astigmatism, cataracts, conjunctivitis, corneal ulcers, dry eye syndrome, eyelid disorders, lacrimal gland tissue disorders, blocked lacrimal ducts, myopia, presbyopia, pupillary disturbances, refract...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/12A61K47/36A61P27/02A61P9/10A61P27/12A61P27/10
Inventor 陈松伟陈诗敏陈静婉曾淑琴
Owner GUANGZHOU BAIEN BIOTECH CO LTD
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