Sodium fusidate freezing-dried powder injection
A technology for sodium fusidate and freeze-dried powder injection, which is applied in the field of freeze-dried powder injection of sodium fusidate, can solve the problems of affecting patient medication safety, unqualified product quality, poor long-term stability, etc. Risk, the effect of improving safety
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[0014] Example 1
[0015] Take the water for injection, let it cool to 30°C, add glycine, arginine, lactose and mannitol according to the prescription amount described in Table 1, and stir to dissolve. Adjust the pH of the solution to 8.0-9.0, add sodium fusidate in the prescribed amount in Table 1, stir to dissolve, and add water for injection to the full amount. Add the special activated carbon for injection to the liquid, stir for 15 minutes, decarbonize and filter. 0.22~0.45μm microporous filter membrane for precise filtration and sterilization, filled with medicinal solution, half-crushed, freeze-dried, out of the box, press-plugged and capped. Reconstituted with buffer solution (components and content: disodium hydrogen phosphate 196mg, citric acid 10mg, EDTA-2Na 5mg, total 10ml), the compatibility with 5% glucose injection and 0.9% sodium chloride injection is selected and stable. Final dosage of agents and excipients. The results of the study are shown in Table 1:
[0016]...
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