50results about How to "Conducive to long-term stability" patented technology

The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and / or vaccine applications. Especially preferred viral formulations disclosed herein are liquid adenovirus formulations, which show improved stability when stored in about the 2-8° C. range while also being compatible with parenteral administration. These formulations comprise a buffer, a sugar, a salt, a divalent cation, a non-ionic detergent, as well as a free radical scavenger and / or a chelating agent to inhibit free radical oxidation.

The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and / or vaccine applications. Especially preferred viral formulations disclosed herein are liquid adenovirus formulations, which show improved stability when stored in about the 2-8° C. range while also being compatible with parenteral administration. These formulations comprise a buffer, a sugar, a salt, a divalent cation, a non-ionic detergent, as well as a free radical scavenger and / or a chelating agent to inhibit free radical oxidation.

The present invention relates to a coordination deformation support system suitable for a soft-rock large-deformation tunnel, and a support method of the support system. The system comprises a tunnel primary support structure and a secondary lining; the tunnel primary support structure comprises an anchoring support structure deep into a stable rock, a first protection layer tightly attached to an inner wall of the surrounding rock, and a foam concrete filling layer positioned at an inner side of the first protection layer; the secondary lining is disposed at an inner side of the foam concrete filling layer; and the first protection layer is formed by a concrete spraying layer having the same thickness in the radial direction of the tunnel and a plurality of compressible cushion blocks. The concrete layer is separated by the compressible cushion blocks, integral flexibility of the concrete layer is largely enhanced, flexible support characteristics of a primary lining can be fully showed, fracture of the primary lining caused by large deformation of the soft rock is prevented, and integrity of the support system is good under combined effects of the foam concrete filling layer, the anchoring support structure and the secondary lining.

The invention discloses composite active bone cement containing sustained release drug-loading nanoparticles. The composite active bone cement comprises sustained release drug-loading nanoparticles and calcium phosphate bone cement, wherein the sustained release drug-loading nanoparticles comprise PEG-b-PLGA polymer drug carriers and hydrophobic medicines. The invention also discloses a method for preparing the composite active bone cement containing sustained release drug-loading nanoparticles. The preparation method comprises the following steps: by taking polyethylene glycol PEG as an initiator, carrying out a ring opening polymerization reaction, thereby obtaining a high-molecular polymer PEG-b-PLGA to serve as a drug carrier; preparing the drug-loading nanoparticles through a solvent volatilization method; and mixing the drug-loading nanoparticles with calcium phosphate bone cement powder, curing and forming, thereby obtaining the composite active bone cement. After the composite active bone cement provided by the invention is implanted into a patient, an eruption effect of the medicine can be reasonably reduced, slow release of the loaded medicines and long-term stabilization of the vertebral body of the patient are facilitated, and the composite active bone cement can serve as a composite tissue engineering scaffold for integrating bone repair and treatment.

The invention discloses a blocking agent kit for immunochromatography determination. The blocking agent kit comprises a kit body and a blocking agent arranged in the kit body. The blocking agent comprises a biological blocking agent and a chemical blocking agent. The biological blocking agent and the chemical blocking agent are separated to be arranged in the kit body. The invention further discloses a method for using the blocking agent kit. According to the blocking agent kit for immunochromatography determination, blocking effects of the biological blocking agent and the chemical blocking agent under endogenous interference factors of different concentrations are brought into full play, the influence on immunochromatography determination caused by the endogenous interference factors in a sample can be effectively prevented and controlled, accuracy of immunochromatography quantitative determination results is improved, and the blocking agent kit has better suitability.

The invention discloses a sidewalk pavement structure for water permeation, water storage and water discharging. The sidewalk pavement structure comprises a sidewalk, a roadway and a rainwater port communicated with a municipal water discharging system and further comprises a transverse water permeation pipe, the sidewalk comprises a water-permeable surface layer, a water-permeable leveling layer, a water-permeable base layer and an inverse filtering cushion which are arranged sequentially from top to bottom, a groove paved with a filling material is formed in the bottom of the inner side of the inverse filtering cushion, and waterproof geotechnical cloth is arranged at the bottom of the inverse filtering cushion, on the left and right sides of the groove and at the bottom of the groove; first kerbs are arranged on two sides of the sidewalk, and the transverse water permeation pipe communicates the groove with the rainwater port. The sidewalk pavement structure has good water permeating, storing and discharging functions, can effectively prevent water accumulation on the surface of the sidewalk and can relieve pressure of the municipal water discharging system under extreme raining conditions to certain extent; rainwater is avoided permeating into roadbeds, so that long-time stability of the roadbeds is guaranteed; water permeability and air permeability of the sidewalk pavement structure can be improved, and urban 'heat island effect' is relieved to certain content.

The invention discloses a sodium fusidate freeze-dried powder injection, including the following components and contents (weight portions) of 450 to 550 of sodium fusidate, 30 to 500 of glycin and 40 to 600 of arginine. The sodium fusidate freeze-dried powder injection has good long-period stability and improves the medication safety for the patient and reduces the medication risk, because certain quantity of stabilizer is added into the sodium fusidate freeze-dried powder injection.

The invention belongs to the field of side slope and bank slope protection engineering, and discloses an anti-seepage and anti-freezing protection system for bank and side slopes of a reservoir in a cold region. The anti-seepage and anti-freezing protection system comprises a foundation embedded in the side slope. A gravel cushion layer, a composite anti-drainage plate and a Renault protection padare sequentially laid from inside to outside on the slope surface of the side slope from the foundation to a set height of the side slope, wherein the set height of the side slope is higher than a surge water level. The anti-seepage and anti-freezing protection system further comprises one-way drainage pipes, wherein the one-way drainage pipes comprise a bottom one-way drainage pipe and a top one-way drainage pipe. The water inlet section of the bottom one-way drainage pipe penetrates through the foundation and extends into the side slope. The water inlet section of the top one-way drainage pipe penetrates through the Renault protection pad, the composite anti-drainage plate and the gravel cushion layer sequentially and extends into the side slope. The invention further discloses a construction method of the anti-seepage and anti-freezing protection system for the bank and side slopes of the reservoir in the cold region. The anti-seepage and anti-freezing protection system is simple in structure, reliable in function, convenient to construct, long in service life, and capable of effectively preventing erosion damage and seepage damage to the bank and side slopes of the reservoir,greatly weakening freezing and thawing damage to the side slope, and ensuring long-term stability of the bank and side slopes of the reservoir.

A soymilk based frozen dessert and process of making the soymilk based frozen dessert. The soymilk based frozen dessert is a calcium fortified soymilk based frozen dessert that uses calcium carbonate as the calcium fortifier.

The invention provides a cup and liner integrated acetabulum component and a preparation method thereof. The cup and liner integrated acetabulum component comprises an acetabulum cup, an acetabulum liner and a bone trabecula structure. The bone trabecula structure is arranged on the outer surface of the acetabulum cup, the acetabulum cup and the bone trabecula structure are formed integrally, theacetabulum liner is in melt connection with the inner surface of the acetabulum cup, and the inner surface of the acetabulum cup is a rough surface with a microporous structure. Preferably, the porosity of the bone trabecula structure is 50%-65%, the pore diameter of the bone trabecula structure is 300-800micron, the acetabulum cup is a metal acetabulum cup, the bone trabecula structure is a metalbone trabecula structure, and the acetabulum liner is a nonmetal acetabulum liner. The cup and liner integrated acetabulum component is structurally firm and stable, capable of improving post-surgical early-stage fixing effects and long-term stability, safe, simple and convenient to use, long in service life, ingenious in design, simple in structure and convenient and simple in manufacturing.

The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and / or vaccine applications. Especially preferred viral formulations disclosed herein are liquid adenovirus formulations, which show improved stability when stored in about the 2-8° C. range while also being compatible with parenteral administration. These formulations comprise a buffer, a sugar, a salt, a divalent cation, a non-ionic detergent, as well as a free radical scavenger and / or a chelating agent to inhibit free radical oxidation.

The invention relates to an artificial joint prosthesis with an anti-infection function, the artificial joint prosthesis is prepared by the following method: (1) surface treatment of the artificial joint prosthesis: polishing the surface of the artificial joint prosthesis to be smooth, then performing ultrasonic cleaning with acetone, ethanol and deionized water, and drying for later use; (2) implanting or depositing silver ions on the surface of the artificial joint prosthesis: depositing the silver ions on the surface of the artificial joint in a magnetron sputtering manner; (3) deposition of a polydopamine coating: firstly preparing a Tris-HCl buffer solution, adding a dopamine hydrochloride solution into the Tris-HCl buffer solution to complete preparation of a dopamine solution, putting the artificial joint prosthesis containing the silver film layer into the dopamine solution, carrying out a reaction in a dark place, and depositing the polydopamine coating on the surface of the artificial joint containing silver ions; and a photothermal effect is generated through irradiation of a 808nm near-infrared light source, so that silver ions generated through in-vivo release and local high temperature generated by near-infrared light have an excellent synergistic sterilization effect, infection can be reduced, and the anti-infection capability of the artificial joint can be enhanced.

The invention belongs to building materials, and particularly relates to light plastering anhydrite which comprises, in 100 parts by weight, 65-80 parts of high-strength anhydrite powder, 4-20 parts of heavy calcium carbonate, 9-20 parts of glass beads, 1-8 parts of methylcellulose, 0.2-5 parts of guar gum mixture and 0.3-4 parts of cassava pregelatinized starch. Raw materials are accurately screened, proportions are scientifically calculated, production technologies are stable and mature, and constructability is strong. The light plastering anhydrite definitely becomes a special green environment-friendly plastering material for novel walls and ceilings in the future, and can be widely applied.

The invention relates to a method for hydrogenating a polymer containing an olefin unsaturated bond. The method comprises: hydrogenation is carried out under the condition that a solution of the polymer containing the olefin unsaturated bond is in contact with hydrogen in the presence of a hydrogenation catalyst, wherein a used hydrogenation reactor comprises two or more than two serially-connected reactors; a first reactor is divided into an upper section and a lower section; the upper section is provided with a filling section and the lower section is an empty tower section; the polymer solution flows through spray headers arranged at the top of the reactors and passes through the filling section by spraying downwards in a hydrogenation process; and then the polymer solution flows into the empty tower section; and reaction effluent of the first reactor is divided into two parts, wherein one part of the reaction effluent enters into a second reactor and the other part of the reactioneffluent is recycled into the first reactor after being subjected to heat exchange in a heat exchanger. According to the method disclosed by the invention, the contact area of the polymer solution and the hydrogen can be enlarged so that the polymer solution and hydrogen are in sufficient contact, thereby improving the hydrogenation efficiency. Furthermore, the temperature in the hydrogenation process further can be stably controlled and the catalyst deactivation caused by excessively-high temperature can be avoided, therefore, a product with ideal hydrogenation degree can be obtained within a longer operation period, and simultaneously the material consumption, the energy consumption and the operation cost in the hydrogenation process can be reduced.

The invention is a vacuum microelectronic acceleration sensor, including active polar plate, insulating layer, vacuum microcavity, top and bottom anode plates and signal detecting circuit. The active polar plate is hollow, the top and bottom anode plates interlink with the active polar plate to form a vacuum cavity in the middle. Where the active polar plate has basal plate which supports a mass block in the middle by cantilever beam, the top and bottom surface of the mass block are distributed with silicon micro field emission cathode cone array and overload protective rings, there is output electrode of the active polar plate on the basal plate, there is another output electrode on the anode plate. The above electrodes are connected with the signal detecting circuit by lines. Its advantages of radioresistance, good temperature stability, fast response, high sensitivity, high resolution, etc, and has extremely wide use.

The invention provides an uncemented tibial component of a trabecular structure. The uncemented tibial component comprises a tibial plateau, a liner and the trabecular structure, wherein the trabecular structure is arranged on the lower surface of the tibial plateau; the tibial plateau and the trabecular structure are integrally molded; the liner is melted on the upper surface of the tibial plateau; and the upper surface of the tibial plateau is a rough surface having a micro-porous structure. Preferably, the porosity of the trabecular structure is 50-65%. The aperture of the trabecular structure is 300-800[mu]m. The tibial plateau is a metal tibial plateau. The trabecular structure is a metal trabecular structure. The liner is a non-metal liner. The invention also provides a making methodof the uncemented tibial component of the trabecular structure. The uncemented tibial component of the trabecular structure provided by the invention is firm and stable in structure, and a postoperative early fixing effect and long-term stabilization can be improved; and the uncemented tibial component is simple and convenient to use, long in service life, skillful in design, concise in structureand simple and convenient to make.

The purpose of the invention is to provide an assembled acetabular prosthesis, a mounting method thereof and a bone defect grinding file device matched with the acetabular prosthesis, which can effectively improve the stability and the service life of the acetabular prosthesis after mounting. The assembled acetabular prosthesis of the invention is composed of an acetabular outer cup and a reinforcing block which is assembled and fixed on one side of the acetabular outer cup. The bone defect file grinder matched with the assembled acetabular prosthesis comprises a handle, a distal end of the handle is detachably mounted with an acetabular adapter, and one side of the acetabular adapter is provided with a notch. The handle is fixed with a rotating shaft sliding sleeve, the rotating shaft sliding sleeve is provided with a rotating shaft through hole on one side of the handle, the rotating shaft through hole is installed with a rotating shaft which can move freely along the axial directionof the rotating shaft through hole, and the rotating shaft is parallel to the handle. The proximal end of the acetabular fitting part is provided with an avoiding part, the rotating shaft extends through the avoiding part to the notch, the distal end of the rotating shaft is detachably mounted with a grinding file head, and the proximal end of the rotating shaft is provided with a connecting partfor connecting with the driver to transmit the torque of the driver.

The invention discloses an all-ceramic artificial hip-joint prosthesis and a preparation method thereof. The artificial hip-joint prosthesis includes a ceramic acetabulum and a ceramic femur. The outer surface of the ceramic acetabulum is hemispherical and is provided with mutually intersected annular grooves and longitudinal grooves; the inner surface of the ceramic acetabulum is in a ball-like shape; the ceramic femur comprises a femoral stem and a femoral head which are connected; the femoral head is attached to the ball-shaped inner surface of the ceramic acetabulum, and connects the ceramic femur with the ceramic acetabulum. Ceramic serves as the preparation material of the prosthesis, and the prosthesis has good abrasion resistance. Besides, the surface of the prosthesis is provided with the grooves, and therefore when the prosthesis is installed, people do not need to use bone cement for fixation and do not need the biological surface for bones to grow into. Stability is achieved through press fit of the prosthesis and bone tissue.

The present invention provides a pelvic prosthesis. The pelvic prosthesis comprises an acetabular cup, an ilium support and a pubis plate are respectively arranged on the acetabular cup, an ilium support connecting plate is arranged on the ilium support, and tantalum coating porous bone trabecular interfaces are arranged at a contact part of the ilium support connecting plate and an ilium, a contact part of the pubis plate and a pubis, and a contact part of the ilium support and human body; a shape of the ilium support is irregular polygon, a plurality of locking long nail holes are arranged in the ilium support, axial directions of the plurality of the locking long nail holes are different, and locking long nails penetrate through the locking long nail holes of the ilium support to be connected with sacrum or lumbar vertebrae. The tantalum coating porous bone trabecular interfaces on the ilium support can ensure a sufficient bonding strength of the prosthesis and a host bone interface, improve long-term stability of the prosthesis in vivo and realize deep fusion of the prosthesis and a host bone tissue; the tantalum coating porous bone trabecular interfaces of the ilium support connecting plate increase stability and safety of the prosthesis and can play roles in mechanical support and bone ingrowth; and the locking long nail holes increase the stability of the prosthesis andreduce mounting difficulty of the prosthesis..

The electrolyte based on AlI3 has the general expression of AlI3(L)n+mM+wI2+xG+yCP+zA, where, the ligand L is organic matter capable of coordinating with AlI3 and the coordination number n is 0-6; the solvent M may be amines, alcohols, nitriles or other organic solvent or ionic liquid and the coordination number m is 0-2000; w as the molar ratio between simple substance I and AlI3 is 0-0.5; the gel G is organic small molecular weight compound or organic high molecular weight compound with the molar ratio to AlI3 x of 0-1; the ceramic powder CP has molar ratio to AlI3 y of 0-5; and the additive A is compound for improving the performance of the electrolyte with the molar ratio to AlI3 z of 0-2. The electrolyte has high long term stability, high conductivity and proper smelting point, and may be used in dye sensitized solar cell and other energy converting and storing devices.

The present invention discloses a pharmaceutical composition comprising GLP-1 analogs. In one embodiment, the composition further comprises buffers, stabilizers, isotonic agents, preservatives, or a mixture thereof. The present invention has the advantage of providing a highly stabilized pharmaceutical formulation of a GLP-1 analog suitable for long-term shelf-life and distribution in the commercial pharmaceutical supply chain. The disclosed formulations effectively protect the active ingredient GLP-1 analogs from degradation, oxidation, precipitation, crystallization, and other factors leading to loss of clinical efficacy.

The invention discloses a safety protection device and method for slope surface green restoration, and relates to the technical field of slope surface green restoration. The device comprises a slope surface, a wire net and earthwork standard rooms. The wire net is laid on the surface of the slope surface. Multiple main anchor rods are evenly distributed on the wire net in a penetrating manner. A retaining wall and a batten which are fixed to the slope surface are arranged at the bottom end and the top end of the wire net correspondingly. Multiple fixed walls are built between the retaining wall and the batten. The earthwork standard rooms are laid between the fixed walls and the retaining wall, between the fixed walls and the batten and between the adjacent fixed walls and are filled withplant soil. According to the safety protection device and method, the wire net is laid on the slope surface and is fixed through the retaining wall, the batten and the fixed walls, then the earthworkstandard rooms are laid in a segmentation manner to achieve safety protection on slope surface green restoration, relative stability of the safety protection device and the slope surface can be effectively increased, and normal growth of vegetation on the slope surface can be guaranteed.

The present invention provides a liquid crystal display panel and a gate drive circuit thereof. The gate drive circuit comprises a plurality of shift register circuit, and the plurality of shift register circuit are series cascade connected, and each shift register circuit comprises: a first pull-up holding circuit, coupled to the first node, the first clock signal, a first reference voltage and a second reference voltage, and employed to keep a low voltage level of the first node; a compensating circuit, coupled to the first node or the first pull-up holding circuit, and employed to compensate the voltage level of the first node or the first pull-up holding circuit. Thereby, the stability of long-term operation of the gate drive circuit can be promoted to raise the quality of the display panel.

This invention relates to an electrolyte based on iodine salt alcohol solution, which is made from mixing iodine salt, simple substance 12 and alcohol solution uniformly and may include ligand compound, additive, gel agent and ceramic powder coordinated with the iodine salt. This invented electrolyte can be used in dye sensitized solar cells or other energy-storage or conversion devices such as electrochemical cells and capacitors and the advantage of the electrolyte is to become liquid state, solid or gel state according to the needs and fills the porous membrane of dye sensitized soalr cells fully and contacts with electrode very well to keep the cell at high photoelectric conversion efficiency.

The invention belongs to the field of tobacco, and particularly relates to a method for detecting the stability of cigarette paper quality, comprising the following steps: obtaining a first DTG curveof a reference cigarette paper and a second DTG curve of the cigarette paper to be tested; calculating a first standard root mean square error of the first DTG curve and the second DTG curve within alignin and / or cellulose pyrolysis temperature range and a second standard root mean square error of the first DTG curve and the second DTG curve within a coke oxidation temperature range; setting afirst threshold value of 6%-15%, and setting a second threshold value of 15%-30%; and if the first standard root mean square error is less than or equal to the first threshold value and the second standard root mean square error is less than or equal to the second threshold value, determining that the quality of the cigarette paper to be tested is stable compared with the reference cigarette paper, otherwise, the quality of the cigarette paper to be tested is not stable compared with the reference cigarette paper. The invention also relates to a device for detecting the stability of cigarettepaper quality. The method of the invention can accurately and comprehensively reflect the stability of the cigarette paper quality, thereby helping to control the long-term stability of the quality and style of the cigarette.

The invention discloses a tibial defect patch set which comprises a supplementing prosthesis and a supplementing tool, the side face, right facing tibial plateau defects, of the supplementing prosthesis is of a bone trabecula structure, a screw hole is formed in the supplementing prosthesis, and a screw is arranged in the screw hole. The supplementary prosthesis provided by the invention is matched with a special supplementary tool, can be independently used without being matched with a tibia support, and can also be matched with prostheses of other manufacturers for use; the prosthesis has multiple specifications and models, and due to the adoption of an anatomical structure design, a defect part can be better covered, and excessive bone mass is prevented from being removed; the operationis convenient and easy; the prosthesis structure adopts a bionic design, and the fixation mode adopts screws and organisms for fixation, so that the short-term and long-term stability of the prosthesis is facilitated.

The invention discloses an endogenous denitrification coupled anaerobic ammonia oxidation municipal sewage deep denitrification device and a method thereof. The device comprises a raw water tank, an SEDA reactor, an intermediate water tank, a PN reactor and a short-cut nitrification effluent water tank, the SEDA reactor is connected with the raw water tank through an SEDA water inlet pump; the SEDA reactor is connected with the middle water tank through a first water outlet valve; wherein the PN reactor is connected with the middle water tank through a PN water inlet pump, the PN reactor is connected with the short-cut nitrification water outlet tank through a PN water outlet valve, the short-cut nitrification water outlet tank is connected with the SEDA reactor through a short-cut nitrification liquid inlet pump, and finally water is discharged through a second water outlet valve of the SEDA reactor. According to the invention, denitrified glycan bacteria and anaerobic ammonia oxidizing bacteria are used for synergistic deep denitrification, so that the problem of insufficient carbon source of low C / N ratio municipal sewage inlet water is solved, and the high efficiency and stability of the denitrification effect of the system are ensured.

The invention discloses a comprehensive energy system energy efficiency analysis method and system considering energy flow links, and the method comprises the steps: S1, analyzing the electric, hot and cold energy flow paths of a comprehensive energy system, dividing the energy flow links of the comprehensive energy system, and obtaining an energy flow model of the comprehensive energy system; S2, based on the energy flow model, analyzing the energy utilization efficiency of the integrated energy system from each energy flow link of the integrated energy system; S3, based on an analysis result, obtaining an energy utilization efficiency analysis calculation expression of the integrated energy system; and S4, analyzing the energy efficiency of the integrated energy system by adopting the calculation expression. Energy supply, conversion, transmission, storage and demand links of the comprehensive energy system are considered, flow of electric / hot / cold energy in the comprehensive energy system is analyzed, then the energy utilization efficiency of the comprehensive energy system is obtained, and the energy efficiency of the comprehensive energy system can be completely analyzed.

The invention discloses a preparation method of a slow-release polyurethane netlike carrier. The method includes the following steps that firstly, a polyurethane foam carrier is provided; secondly, ahigh-molecular mixed solution containing natural polymer polysaccharides, water and a enrichment culture medium is provided; thirdly, the high-molecular mixed solution is used for dipping the polyurethane foam carrier; fourthly, the polyurethane foam carrier obtained after dipping makes contact with a cross-linking agent to form reversible gel, and the slow-release polyurethane netlike carrier isobtained. The invention further provides application of the slow-release polyurethane netlike carrier in chemical wastewater treatment.

The present invention discloses a formula for prevention and treatment of acute severe pancreatitis combined with liver damage. The formula comprises a formula in a prevention stage and a formula in atreatment stage. The specific formula is as follows: in the prevention stage: 0.01-0.05 g / Kg body weight of radix scutellariae + 0.01-0.015g / Kg body weight of radix salviae miltiorrhizae; and in thetreatment stage: 0.01-0.05 g / Kg body weight of radix scutellariae + 0.02-0.03 g / Kg body weight of radix salviae miltiorrhizae. The formula has the prevention function on high-risk populations, has a certain degree of remission and control effects on occurrence and development of the disease, and effectively alleviates severity of the acute severe pancreatitis combined with the liver damage, breaksa limitation of "one prescription for thousand people" of traditional medicines using body weight as a basis for medicine use, enables the medicine use to be personalized and quantified as much as possible, conducts precautionary intervention on the high-risk populations in an early stage, groups, conducts early small dose prevention, can comprehensively adjust human body functions, is slightly increased in the medicine use dosage after the onset, can enable severity to be reduced and treatment difficulty to be low after the onset of patients, can be smoothly absorbed by human body, enables digestive system functions to be slowly and orderly restored, can promote rehabilitation and facilitates long-term stability in the future.