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Composite active bone cement containing sustained release drug-loading nanoparticles and preparation method of bone cement

A drug-loaded nano and bone cement technology, applied in medical science, surgical adhesives, prostheses, etc., can solve the problems of poor bone conduction effect, poor water solubility, small pore size, etc., and achieve the effect of reducing the burst effect

Active Publication Date: 2015-01-21
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the calcium phosphate bone cement solidified body has low porosity and small pore size, and it is difficult for new bone to grow into it. Although the pore size can be increased by adding sodium bicarbonate, sodium chloride grains or sucrose, there is a lack of small pores between the micropores. Communication, bone conduction effect is not good, and the increase in porosity will lead to a sharp decrease in the strength of the material
At the same time, the slow degradation of the scaffold system composed of polymer microspheres and calcium phosphate bone cement is not conducive to rapid bone healing, and the drug release rate cannot be controlled
And at present, many anticancer drugs and anti-inflammatory drugs are greatly limited in clinical application due to poor water solubility and difficult preparations. Therefore, the successful development of calcium phosphate bone cement with drug sustained release function will make existing materials Performance leaps to a new level

Method used

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  • Composite active bone cement containing sustained release drug-loading nanoparticles and preparation method of bone cement
  • Composite active bone cement containing sustained release drug-loading nanoparticles and preparation method of bone cement
  • Composite active bone cement containing sustained release drug-loading nanoparticles and preparation method of bone cement

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Effect test

Embodiment 1

[0052] A method for preparing a revitalized bone cement containing sustained-release drug-loaded nanoparticles, comprising the steps of:

[0053] (1) Preparation of nanoparticles loaded with docetaxel:

[0054] Weigh 30% lactide monomer, 40% glycolide monomer and 29.9% polyethylene glycol (M w =5000) mix, put into the polymerization tube, then add the tributyl tin chloride that mass percent is 0.1% to obtain the mixed reaction raw material; Carry out vacuumizing and degassing and then fill with nitrogen, repeat three times, make the formation of nitrogen protection in the polymerization tube environment; the polymerization tube is sealed, and the ring-opening polymerization reaction is carried out under heating in an oil bath at 150°C, and the polymerization product is obtained after 6 hours of reaction; the obtained polymerization product is dissolved in the first organic solvent dichloromethane after cooling, and the polymerization The product includes the polymer generated...

Embodiment 2

[0076] A method for preparing a revitalized bone cement containing sustained-release drug-loaded nanoparticles, comprising the steps of:

[0077] (1) Preparation of nanoparticles loaded with doxorubicin:

[0078] Weigh 35% of lactide monomer, 29% of glycolide monomer and 35% of polyethylene glycol (Mw=5000) by mass percentage, mix them, put them into a polymerization tube, and add mass percentage Tributyltin chloride with a content of 1% is used to obtain mixed reaction raw materials; after vacuuming and degassing, nitrogen is filled, and repeated three times, so that nitrogen is formed in the polymerization tube to protect the environment; the polymerization tube is sealed and heated in an oil bath at 150°C. Ring-opening polymerization, reacting for 8 hours to obtain a polymer product; the resulting polymer product is cooled and dissolved in the first organic solvent chloroform, the polymer product includes polymers generated by the polymerization reaction, unreacted lactide ...

Embodiment 3

[0083] A method for preparing a revitalized bone cement containing sustained-release drug-loaded nanoparticles, comprising the steps of:

[0084] (1) Preparation of nanoparticles loaded with 5-fluorouracil:

[0085] Weigh 50% of lactide monomer, 40% of glycolide monomer and 9% of polyethylene glycol (Mw=2000) by mass percentage, mix them, put them into a polymerization tube, and add mass percentage The content of stannous isooctanoate with a content of 1% is obtained as a mixed reaction raw material; after vacuuming and degassing, nitrogen is filled, and repeated three times, so that nitrogen is formed in the polymerization tube to protect the environment; the polymerization tube is sealed, and the ring is opened under heating in an oil bath at 170°C Polymerization reaction, after 12 hours of reaction, a polymer product is obtained; the resulting polymer product is cooled and dissolved in tetrahydrofuran, the first organic solvent, and the polymer product includes the polymer ...

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Abstract

The invention discloses composite active bone cement containing sustained release drug-loading nanoparticles. The composite active bone cement comprises sustained release drug-loading nanoparticles and calcium phosphate bone cement, wherein the sustained release drug-loading nanoparticles comprise PEG-b-PLGA polymer drug carriers and hydrophobic medicines. The invention also discloses a method for preparing the composite active bone cement containing sustained release drug-loading nanoparticles. The preparation method comprises the following steps: by taking polyethylene glycol PEG as an initiator, carrying out a ring opening polymerization reaction, thereby obtaining a high-molecular polymer PEG-b-PLGA to serve as a drug carrier; preparing the drug-loading nanoparticles through a solvent volatilization method; and mixing the drug-loading nanoparticles with calcium phosphate bone cement powder, curing and forming, thereby obtaining the composite active bone cement. After the composite active bone cement provided by the invention is implanted into a patient, an eruption effect of the medicine can be reasonably reduced, slow release of the loaded medicines and long-term stabilization of the vertebral body of the patient are facilitated, and the composite active bone cement can serve as a composite tissue engineering scaffold for integrating bone repair and treatment.

Description

technical field [0001] The invention belongs to the field of orthopedic tissue engineering, in particular to a composite active bone cement containing slow-release drug-loaded nanoparticles and a preparation method thereof. Background technique [0002] In recent years, the incidence of bone defects due to industrial accidents, traffic accidents, orthopedic diseases, etc. has been high. In addition, my country is currently moving towards an aging society, and the number of orthopedic degenerative diseases related to the elderly population continues to increase. The demand for materials is increasing. [0003] Bone cement is a bone repair material used in orthopedic surgery. At present, the drug release carriers for bone repair that have been studied more at home and abroad mainly include porous hydroxyapatite ceramics (HAP) and polymer microspheres and calcium phosphate cement (CPC). Composite support system. Porous hydroxyapatite ceramic (HAP) microspheres or scaffolds hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/54A61L27/50A61L24/04A61L24/02
Inventor 高楠莎阮长顺潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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