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Preparation method for antibacterial liquid-absorbing gauze

A technology of gauze and degreasing gauze, which is applied in the preparation of medical gauze and antibacterial liquid-absorbing gauze, can solve the problems of delayed healing of wound surface, compression of wound surface, secondary damage of wound surface, etc., which affect the migration of wound epithelial cells, and increase the characteristics of polycations, Enhance the liquid absorption performance and promote the effect of wound healing

Inactive Publication Date: 2013-11-20
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still three major problems in the clinical use of gauze: first, gauze does not have any antibacterial function, and the effect is very poor when treating infected or potentially infected wounds; second, gauze has poor liquid absorption performance. Poor, not suitable for exudative wounds; Third, after gauze absorbs the exudate, it will solidify and harden in a short period of time, compressing the wound, affecting the migration of wound epithelial cells and causing delayed wound healing. In addition, granulation tissue It is easy to grow into the gauze mesh, causing adhesion between the granulation tissue and the gauze. When changing the dressing, taking off the gauze will cause secondary damage to the wound surface, affect wound healing, and cause pain at the same time, bringing great pain to the patient
This case provides a preparation process of dissolving hemostatic gauze. By carboxymethylating the hydroxyl group on the gauze, the dissolving hemostatic gauze with good solubility and rapid hemostasis is obtained, which solves the problem of unsatisfactory hemostatic effect of traditional gauze
However, this preparation process does not introduce antibacterial groups into the molecular chain of the gauze, nor treat the gauze with antibacterial drugs, so that the antibacterial effect of the gauze formed by this preparation process is relatively poor, and it is easy to cause secondary infection of the wound. Not suitable for susceptible or infected wounds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] A preparation method of antibacterial liquid-absorbing gauze, described preparation method is carried out according to the following steps:

[0023] a Arrange the degreased yarn in the reaction chamber of the plasma processing apparatus for glow discharge treatment, the working gas is oxygen, the pressure of the reaction chamber is 20Pa, the processing power is 100W, and the processing time is 15-60s to form an active degreasing gauze body;

[0024] Since the component of degreasing gauze is cellulose, its molecular chain is formed by connecting D-glucose groups through β-1,4-glucosidic bonds. There are a large number of hydroxyl groups on the cellulose molecular chain, and there are strong hydrogen bonds between and within the molecules, making it difficult to dissolve cellulose in general solvents, and it is difficult for the quaternary ammonium salt modifier molecules to enter the crystallization area of ​​cellulose. The reaction can only take place in the amorphous ...

Embodiment 1

[0034] Arrange the degreased yarn in the reaction chamber of the plasma treatment apparatus, pass in oxygen, adjust the pressure of the reaction chamber to 20Pa, the processing power to 100W, and perform glow discharge for 15s. Weigh 5.0 g of plasma-treated degreased gauze, add 100 mL of NaOH solution with a concentration of 20 wt %, stir at room temperature for 1 h, and after centrifugal drying, disperse it in 250 mL of methanol, add 2,3-epoxypropyl trimethyl Ammonium chloride 1.40g, stirred evenly at room temperature, reacted in a constant temperature water bath at 25°C for 0.5h, separated the degreased gauze after the reaction from the reaction mixture, and dispersed the degreased gauze in 80% ( v / v) In methanol aqueous solution, add 15% (v / v) acetic acid aqueous solution dropwise, adjust the pH of the mixture of methanol and acetic acid aqueous solution to 7.1, soak for 30 minutes, and then separate the soaked degreasing gauze from the mixed solution, Washed twice with 80%...

Embodiment 2

[0036] Arrange the degreased yarn in the reaction chamber of the plasma treatment apparatus, feed oxygen, adjust the pressure of the reaction chamber to 20Pa, and the processing power to 100W, and perform glow discharge for 40s. Weigh 5.0 g of plasma-treated degreased gauze, add 100 mL of NaOH solution with a concentration of 25 wt %, stir at room temperature for 1 h, and after centrifugal drying, disperse it in 250 mL of ethanol, add 2,3-epoxypropyl trimethyl Ammonium chloride 28.08g, after stirring evenly at room temperature, reacted in a constant temperature water bath at 50°C for 3.0h, separated the degreased gauze after the reaction from the reaction mixture, and dispersed the degreased gauze in 80% ( v / v) in ethanol aqueous solution, dropwise add 15% (v / v) acetic acid aqueous solution, adjust the pH of ethanol and acetic acid aqueous solution mixture to 6.0, soak for 30 minutes, then separate the soaked degreasing gauze from the mixed solution, Washed twice with 80% (v / v...

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Abstract

The invention relates to a preparation method for an antibacterial liquid-absorbing gauze, which belongs to the field of preparation of medical dressings. According to the invention, a quaternary ammonium salt group is introduced onto a cellulose molecular chain of a degreased gauze through an epoxide ring-opening or nucleophilic substitution reaction, so polycation characteristics of cellulose of the gauze are increased, and antibacterial properties of the gauze are improved; through controlling of a mol ratio of a hydroxyl group to a quaternary ammonium salt on the cellulose molecular chain of the degreased gauze and reaction conditions, the degree of substitution of the quaternary ammonium salt on the cellulose molecular chain is in a range of 5 to 80%, so the reacted gauze has high antibacterial properties and high liquid absorption performance and can maintain the basic form of yarns after absorption of liquid. The antibacterial liquid-absorbing gauze prepared by using the preparation method provided by the invention overcomes the defect of a single function of a conventional medical gauze, is applicable to an infectious wound with a great amount of exudate or an infectible wound and exerts the effects of killing of bacteria on the surface of the wound and absorption of exudate on the surface of the wound. The preparation method for the antibacterial liquid-absorbing gauze has the advantages of easiness, low cost and easy industrial production.

Description

technical field [0001] The invention relates to a preparation method of medical gauze, in particular to a preparation method of antibacterial liquid-absorbing gauze, which belongs to the field of preparation of medical dressings. Background technique [0002] Gauze is a medical dressing widely used in hospitals. It is mainly used to bandage wounds and play a role in wound protection. However, there are still three main problems in the clinical use of gauze: first, gauze does not have any antibacterial function, and the effect is very poor when treating infected or potentially infected wounds; second, gauze has poor liquid absorption performance. Poor, not suitable for exudative wounds; Third, after gauze absorbs the exudate, it will solidify and harden in a short period of time, compressing the wound, affecting the migration of wound epithelial cells and causing delayed wound healing. In addition, granulation tissue It is easy to grow into the gauze mesh, causing adhesion b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M10/00D06M11/38D06M13/463D06M13/188A61L15/46D06M101/06
Inventor 周应山徐卫林杨红军施龙献李芳
Owner WUHAN TEXTILE UNIV
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