The invention discloses a preparation method and system of a removable partial denture based on artificial intelligence. The method includes the following steps of 1, oral cavity examination, 2, toothpreparation, 3, model refinement, 4, dental cast manufacture, and 5, try-in and adjustment. The main mode manufacture process includes abutment tooth selection, database building and three-dimensional design. The system of the removable partial denture based on artificial intelligence includes a data input module, a data preprocessing module, a database, a data comparison module, a data adjustment module and a data output module. The output end of the data input module is in signal connection with the input end of the data preprocessing module. According to the preparation method and system of the removable partial denture based on artificial intelligence, when a base support is manufactured, through the combination of the actual situation and past cases, the manufacturing cycle is greatly reduced, many unnecessary troubles are avoided, patients do not need to run in removable partial dentures for a long time, the running-in cycle and pain are reduced, the work efficiency is improved,and the cost is thus reduced.