Postoperative washing agent and preparation method thereof

A technology of flushing agent and cross-linking agent, applied in the field of medicine, can solve problems such as limited joint movement, and achieve the effects of good adhesion, low cost and stable quality

Inactive Publication Date: 2014-09-10
陈凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process occurs in the joint capsule, sarcolemma, muscle junction tissue, ligaments, etc., resulting in limited joint motion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A post-operative rinse consisting of sodium hyaluronate, carboxymethyl chitin and a cross-linking agent, the cross-linking agent being glutaraldehyde or epichlorohydrin or ethylene glycol bisglycidyl ether or glycerol bisglycidyl ether Glyceryl ether, the mass ratio of the three is 1:1:0.5.

Embodiment 2

[0017] A post-operative rinse consisting of sodium hyaluronate, hydroxypropyl chitin and a cross-linking agent such as glutaraldehyde or epichlorohydrin or ethylene glycol bisglycidyl ether or glycerol bisglycidyl ether The mass ratio of the three glycerol ethers is 1:0.5:0.3.

Embodiment 3

[0019] A post-operative rinse consisting of sodium hyaluronate, succinyl chitin, and a cross-linking agent such as glutaraldehyde or epichlorohydrin or ethylene glycol bisglycidyl ether or glycerol bisglycidyl Ether, the mass ratio of the three is 1:0.3:0.2.

[0020] Examples 1-3 were prepared according to the following preparation method. The sodium hyaluronate, chitin derivatives and cross-linking agent were weighed and mixed according to the above formula, and then ground into fine powder, and the fine powder was passed through a 200-mesh sieve. The fine powder is packaged in an aluminum foil bag, and after being sterilized by ethylene oxide or microwave, the postoperative flushing agent is obtained.

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PUM

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Abstract

The invention belongs to the field of medicines, and in particular relates to a postoperative washing agent and a preparation method thereof; the postoperative washing agent is composed of sodium hyaluronate, a chitin derivative and a cross-linking agent, wherein the mass ratio of the sodium hyaluronate, the chitin derivative to the cross-linking agent is 1:(0.3-1):(0.1-0.5). The preparation method disclosed by the invention comprises the following steps: weighing and mixing the sodium hyaluronate, the chitin derivative and the cross-linking agent according to the formula, grinding into fine powder, sieving fine powder through a 200-mesh sieve, packaging sieved fine powder by using an aluminium foil bag, sterilizing through ethylene oxide or microwave, and obtaining the postoperative washing agent. The postoperative washing agent and the preparation method thereof disclosed by the invention have the advantages that various components of medicines are matched with each other and used by being prepared into the washing agent; the postoperative washing agent has the obvious effects for preventing postoperative joint tissue adhesion, recovering and healing wound surfaces and easing pain; and furthermore, the postoperative washing agent disclosed by the invention is steady in quality, low in cost, convenient for use and good in tissue adhesion and accords with clinical use requirements.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a postoperative flushing agent and a preparation method thereof. Background technique [0002] Joint adhesion refers to the movement disorder caused by changes in the skin, muscles, tendons, blood vessels and nerves around the joint. There are loose components and dense components in the tissues of the human body. The former constitute joint capsules, muscle-combining tissue layers, subcutaneous tissue, etc., which are often active parts. Histologically, the collagen fibers and fine mesh fibers do not have a mesh shape and do not have a certain structure. . In contrast, densely bonded tissues, such as fascia and aponeurosis, form a dense network. The scar that forms after an injury is this tissue. During the treatment of orthopedic joint trauma, if the movement of the site is maintained, the loose joint tissue can be maintained; on the contrary, if the movement is restricte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 陈凯
Owner 陈凯
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