Preparation method for small-diameter artificial silk fibroin blood vessel with high unblocked rate

An artificial blood vessel, small-caliber technology, applied in medical science, prosthesis, etc., can solve problems such as small-caliber blood vessel blockage, and achieve the effects of high suture force, controllable preparation process conditions, and high blasting pressure.

Inactive Publication Date: 2015-09-23
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a method for preparing a silk fibroin small-diameter artificial blood vessel with a good patency rate. The silk fibroin artificial blood vessel of the present invention belongs to natural materials, has good biocompatibility, high patency rate, and is simple to prepare. Blockage of small-bore blood vessels brings hope

Method used

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  • Preparation method for small-diameter artificial silk fibroin blood vessel with high unblocked rate

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Evenly coat the silk fibroin solution with a concentration of 300mg / ml on the outer wall of the metal tube, the diameter of the metal tube is 5mm, start the motor linkage device, the rotation speed is 50rpm, control the heating rod to slowly heat up to 80°C, and after the solution is dried, Terminate heating, cool to room temperature, soak in absolute ethanol or ethanol aqueous solution for 1-3 days, then remove the hollow tube from the mold surface, and dry at room temperature for 1-3 days to obtain a single layer of silk with a diameter of 5mm Su small-caliber artificial blood vessels.

Embodiment 2

[0027] The method of Example 1 was repeated, wherein the concentration of the silk fibroin solution was 500 mg / ml to obtain a silk fibroin small-diameter artificial blood vessel with a monolayer diameter of 5 mm.

Embodiment 3

[0029] The method of Example 1 was repeated, wherein the concentration of the silk fibroin solution was 500 mg / ml, and the rotation speed was 150 rpm to obtain a silk fibroin small-caliber artificial blood vessel with a monolayer diameter of 5 mm.

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Abstract

The invention discloses a preparation method for a small-diameter artificial silk fibroin blood vessel with high unblocked rate, and belongs to the field of biomedical materials. The small-diameter artificial silk fibroin blood vessel is obtained by uniformly coating a specific metal mould with an anticoagulant modified silk fibroin solution, performing rotary forming and heat drying, and soaking in an ethanol aqueous solution. Silk fibroin blood vessels different in performance and shape can be prepared as needed; the mechanical performance of the blood vessel is controlled by regulating the rotational speed and the drying temperature of the mould; the thickness of the blood vessel is controlled by the number of coating layers; the diameter of the blood vessel is controlled by regulating the diameter of the mould. The silk fibroin blood vessel obtained by the preparation method has good biocompatibility, blood compatibility and mechanical performance; the diameter of the silk fibroin blood vessel is smaller than 6 mm, the silk fibroin blood vessel is formed once, and the preparation process is simple; the silk fibroin blood vessel is good in adaptability and free of obvious stress defects, keeps unblocked in an animal body within 6 months, and lays a certain foundation for clinical application of small-diameter blood vessels.

Description

technical field [0001] The invention is to prepare a silk fibroin small-diameter artificial blood vessel with good patency rate, and relates to the field of biomedical materials. Background technique [0002] Cardiovascular disease is one of the common diseases that endanger human health. For more serious patients, the most commonly used treatment and auxiliary treatment is vascular transplantation. A vascular substitute is required for this procedure. Therefore, it is necessary to develop medical artificial blood vessels. Since the polyester artificial blood vessel was developed in 1957, various materials and various shaped artificial blood vessels have been developed successively at home and abroad. Artificial blood vessels have been developed to this day, although several major leaps have been experienced, but the improvement of the long-term patency rate after small-caliber (less than 6mm) artificial blood vessel transplantation has always been the primary problem to b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/50
Inventor 曹传宝马西兰王旭霞
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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