Application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases

A fucoidan and peripheral arterial technology, applied in cardiovascular system diseases, medical raw materials derived from algae, medical preparations containing active ingredients, etc., can solve the problems of inoperable patients, short half-life, restenosis, etc. Effects of blood flow, reducing pathological changes, and improving plantar temperature

Active Publication Date: 2016-06-15
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the commonly used clinical treatment methods and their defects are: 1) surgical treatment such as vascular bypass surgery, the prognosis is good, but some patients cannot be operated on, and postoperative restenosis occurs; 2) vascular endothelial growth factor (vascular endothelial growth factor, VEGF ) and other growth factors that promote angiogenesis, but they are expensive, unstable in the body, easily degraded, and have a short half-life; 3) There is still a l

Method used

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  • Application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases
  • Application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases
  • Application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases

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Effect test

Embodiment 1

[0036] Example 1, the application of fucoidan sulfate in the preparation of products for the prevention and / or treatment of lower extremity peripheral arterial vascular disease

[0037] Materials and Methods

[0038] 1. Grouping, administration and modeling of experimental animals:

[0039] Wistar rats weighing 300-330 g were selected in the experiment, and after one week of adaptive feeding, they were randomly divided into groups. The experiment was divided into model group (normal saline, gavage), drug treatment group (LMWF, 100mg / kg, gavage), positive drug group (cilostazol, 25mg / kg, gavage). The peripheral vascular disease (PAD) model was administered two days before, which was recorded as Day (-2). The peripheral arterial thromboembolism model induced by sodium laurate injection was administered five days before the operation, which was recorded as Day(-5).

[0040] 2. Surgical modeling of peripheral vascular disease (PAD):

[0041] Anesthetize the rat with 6% chloral...

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Abstract

The invention discloses application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases.The fucoidan is applied to preparing the products for preventing and/or treating the lower limb peripheral artery vascular diseases.The application has the advantages that the low-molecular-weight fucoidan (LMWF) comes from the naturally available thallus laminariae, is easily available and is safe; certain improvement effects can be realized for the lower limb peripheral artery vascular diseases; the products with the low-molecular-weight fucoidan can be absorbed if the products are orally administered, and have a potential application significance on preventing and treating the lower limb peripheral artery vascular diseases, side effects rarely can be realized, and the like.

Description

technical field [0001] The invention relates to the application of fucoidan sulfate in the preparation of products for preventing and / or treating peripheral arterial vascular diseases of lower extremities. Background technique [0002] Peripheral arterial disease (PAD), especially peripheral arterial disease of the lower extremities, is a common clinical disease with a wide range of patients. The pathological changes are continuous increase of atherosclerotic substances in arteries and secondary thrombus formation, causing arterial lumen stenosis and occlusion, causing chronic or acute ischemic symptoms in limbs. The etiology is not completely clear, and it is generally believed that it is related to various factors such as age, smoking, blood lipids, diabetes, hyperlipidemia, hypertension, genetic factors, and mental stress. The clinical manifestations are characterized by symptoms such as intermittent claudication, rest pain, and refractory ulcer [Mascarenhas.JV., et al.,...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61P9/10A61P9/00A61P9/14
CPCA61K31/737A61K36/02A61K36/03
Inventor 罗大力王志强刘甜甜张全斌郑元元
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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