Application of fucoidan to preparing products for preventing and/or treating lower limb peripheral artery vascular diseases

Abstract

The invention discloses application of fucoidan to preparing products for preventing and / or treating lower limb peripheral artery vascular diseases.The fucoidan is applied to preparing the products for preventing and / or treating the lower limb peripheral artery vascular diseases.The application has the advantages that the low-molecular-weight fucoidan (LMWF) comes from the naturally available thallus laminariae, is easily available and is safe; certain improvement effects can be realized for the lower limb peripheral artery vascular diseases; the products with the low-molecular-weight fucoidan can be absorbed if the products are orally administered, and have a potential application significance on preventing and treating the lower limb peripheral artery vascular diseases, side effects rarely can be realized, and the like.

Description

technical field [0001] The invention relates to the application of fucoidan sulfate in the preparation of products for preventing and / or treating peripheral arterial vascular diseases of lower extremities. Background technique [0002] Peripheral arterial disease (PAD), especially peripheral arterial disease of the lower extremities, is a common clinical disease with a wide range of patients. The pathological changes are continuous increase of atherosclerotic substances in arteries and secondary thrombus formation, causing arterial lumen stenosis and occlusion, causing chronic or acute ischemic symptoms in limbs. The etiology is not completely clear, and it is generally believed that it is related to various factors such as age, smoking, blood lipids, diabetes, hyperlipidemia, hypertension, genetic factors, and mental stress. The clinical manifestations are characterized by symptoms such as intermittent claudication, rest pain, and refractory ulcer [Mascarenhas.JV., et al.,...

AI Technical Summary

Problems solved by technology

At present, the commonly used clinical treatment methods and their defects are: 1) surgical treatment such as vascular bypass surgery, the prognosis is good, but some patients cannot be operated on, and postoperative restenosis occurs; 2) vascular endothelial growth factor (vascular endothelial growth factor, VEGF ) and other growth factors that promote angiogenesis, but they are expensive, unstable in the body, easily degraded, and have a short half-life; 3) There is still a lack of more clinical evidence for cell-level treatments such as vascular endothelial leader cells Prove its effectiveness; 4) The treatment of related drugs such as antiplatelet aggregation, anticoagulation, and blood vessel expansion can relieve symptoms to a certain extent, but long-term use may cause adverse reactions such as bleeding [Forsythe, RO., et al., Management of peripheral arterial disease and the diabetic foot. JCardiovascSurg(Torino).2014;55(2Suppl1):p.195-206.]

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