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Applications of ammonium pyrrolidine carbodithioic salt in preparation of drug for preventing decompression sickness caused by fast buoyant ascent escape

A technology of ammonium pyrrolidine dithioformate and pyrrolidine dithioformate, which is applied in the direction of drug combinations and active ingredients of heterocyclic compounds, and can solve the problems that no research has confirmed the prevention of decompression sickness, and it has not been used for prevention. , to achieve the effect of inhibiting heart failure, reducing pathological changes, reducing lung damage and inflammation

Inactive Publication Date: 2014-07-23
NAVY MEDICINE RES INST OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no studies have confirmed that this molecule can be used to prevent decompression sickness, and it has not been used to prevent decompression sickness caused by rapid ascent and escape

Method used

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  • Applications of ammonium pyrrolidine carbodithioic salt in preparation of drug for preventing decompression sickness caused by fast buoyant ascent escape
  • Applications of ammonium pyrrolidine carbodithioic salt in preparation of drug for preventing decompression sickness caused by fast buoyant ascent escape
  • Applications of ammonium pyrrolidine carbodithioic salt in preparation of drug for preventing decompression sickness caused by fast buoyant ascent escape

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Injection drug for experiment: Use physiological saline to prepare ammonium pyrrolidine dithioformate into a 25 mg / ml solution and prepare it as an injection.

[0021] Experimental animals and grouping: 60 male healthy SD rats, weighing 220-250 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd. SD rats were randomly divided into prevention group and control group, 30 in each group.

[0022] Experimental method: 30 minutes before the treatment of the prevention group, by intraperitoneal injection of ammonium pyrrolidine dithioformate solution (injection dose is 100mg / kg), 30 minutes before the treatment of the control group, by intraperitoneal injection of an equal volume of normal saline, after which the experimental animals were placed Close the door of the fast-floating and escape pressurized cabin, and use the self-programmed computer-automated fast-float and escape procedure, use the method of doubling the compressed air index within 28 seconds (dou...

Embodiment 2

[0029] Injection drug for experiment: Use physiological saline to prepare ammonium pyrrolidine dithioformate into a 120 mg / mL solution, and prepare it as an injection.

[0030] Experimental animals and grouping: 16 male healthy New Zealand rabbits, weighing 2.6-3 kg, were purchased from Shanghai Slack Experimental Animal Co., Ltd. Rabbits were randomly divided into prevention group and control group, with 8 rabbits in each group.

[0031] Experimental method: 20 minutes before treatment in the prevention group, inject pyrrolidine ammonium dithioformate solution (injection dose is 40 mg / kg) through the ear vein, 20 minutes before the treatment in the control group, inject an equal volume of normal saline through the ear vein, and then Put the experimental animals in the pressurized chamber for rapid escaping and escape, close the door, use the self-programmed computer to automate the rapid escaping and escaping procedure, and use compressed air to double the pressure within 24 ...

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Abstract

The invention belongs to the field of medicine preparation, and particularly relates to applications of ammonium pyrrolidine carbodithioic salt in preparation of a drug for preventing decompression sickness caused by fast buoyant ascent escape. The ammonium pyrrolidine carbodithioic salt is dissolved in normal saline to prepare 25-125mg / mL of injection for use. The dose of ammonium pyrrolidine carbodithioic salt intraperitoneal injection is 80-120mg / kg, and the dose of ammonium pyrrolidine carbodithioic salt intravenous injection is 30-50mg / kg. The ammonium pyrrolidine carbodithioic salt is used at 20-35 minutes before fast buoyant ascent escape. The experiments show that the ammonium pyrrolidine carbodithioic salt can obviously inhibit the heart failure caused by myocardial fiber fracture due to bubbles so as to improve the cardiac function and lighten the injury and inflammation of the lung, so that the pathologic change caused by the decompression sickness can be lightened. Furthermore, the applications can provide experimental data for clinically more reasonably applying the ammonium pyrrolidine carbodithioic salt onto the decompression sickness caused by the fast buoyant ascent escape.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and particularly relates to the application of ammonium pyrrolidine dithioformate in the preparation of medicines for preventing decompression sickness caused by rapid ascent and escape. Background technique [0002] As one of the main methods for underwater escape of submarine crews generally adopted by the navies of various countries, fast surfacing is to use the principle of no-decompression diving to make the crew escape from the wrecked ship at a large depth. Because of its advantages such as simple equipment, easy method, large escape depth and simple operation, it has been adopted by many countries. However, as the depth deepens, the high-pressure exposure time allowed by the crew is quite limited. If the exposure time is too long due to improper pressure adjustment and other reasons, severe decompression sickness will occur. [0003] The pathogenesis of decompression sickness is that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61P43/00
Inventor 方以群攸璞王海涛包晓辰李丹姚健袁恒荣马骏王芳芳
Owner NAVY MEDICINE RES INST OF PLA
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