The invention discloses a drug combination for treating rheumatism arthritis and a preparation method thereof. The drug combination for treating rheumatism arthritis comprises, by weight, 10-30 parts of panax japonicas, 10-30 parts of astilbe chinensis, 10-30 parts of paris polyphylla, 20-60 parts of clematis henryi oliv, 15-45 parts of toddalia asiatualam and 15-45 parts of Indian damnacanthus herbs. The preparation method includes the steps that raw medicines are weighed separately and subjected to 160-mesh sieving, and the raw medicines are obtained; and the raw medicines including the panax japonicas, the astilbe chinensis, the paris polyphylla, the clematis henryi oliv, the astilbe chinensis and the Indian damnacanthus herbs are mixed evenly, and the drug combination for treating rheumatism arthritis is obtained. The drug combination for treating rheumatism arthritis has the effects of dispelling wind, eliminating dampness, dispersing blood stasis, relieving pain, promoting qi to activate blood, warming and activating meridian, and achieving nourishing and strengthening, has significant clinical effects and has no obvious toxic or side effects. The drug combination for treating rheumatism arthritis has a significant therapeutic effect on arthritis induced by a complete Freund's adjuvant, has good anti-inflammatory and analgesic effects, achieves the pharmacological function significantly superior to that of a single medicinal material and other compatible combinations, plays a synergetic interaction and has low toxic and side effects.