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Medical composition for treating rheumatoid arthritis and preparation method and application thereof

A composition and arthritic technology, applied in the field of medicine, can solve problems such as side effects, and achieve the effects of reducing joint swelling, inhibiting hyperplasia, and improving joint damage

Inactive Publication Date: 2018-09-07
宋健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-steroidal anti-inflammatory drugs are commonly used clinically to relieve symptoms, but long-term use has side effects

Method used

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  • Medical composition for treating rheumatoid arthritis and preparation method and application thereof
  • Medical composition for treating rheumatoid arthritis and preparation method and application thereof
  • Medical composition for treating rheumatoid arthritis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] The synthesis of experimental example 1 medicine of the present invention

[0022] route:

[0023]

[0024] Step A: 6-Chloro-3-methoxy-[1,2,4]triazolo[4,3-b]pyridazine

[0025]

[0026] To a solution of 3-chloro-6-hydrazinopyridazine (5.00 g, 0.035 mol) in dioxane (80 mL) was added tetramethylorthocarbonate (7.06 g, 0.052 mol) dropwise at room temperature. After the addition, it was heated to 100°C for 3 hours to react. After the reaction was completed, it was cooled and concentrated under reduced pressure. The residue was poured into isopropyl ether and stirred for 15 minutes. The solid was collected by filtration to obtain the product (6.00 g, 94%).

[0027] 1 H NMR (400MHz, d 6 -DMSO) δ 4.25 (s, 3H), 7.30 (d, 1H), 8.22 (d, 1H).

[0028] Step B: 3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

[0029]

[0030] Add dropwise to 6-chloro-3-methoxy-[1,2,4]triazolo[4,3-b]pyridazine (6.00g, 0.033mol) in n-butanol (60mL) at room temperature Ammonia (20 mL)....

experiment example 2

[0036] Experimental example 2 the effect of medicine treatment rheumatoid arthritis of the present invention

[0037] Establishment of Rat Model of Rheumatoid Arthritis

[0038] After 1 week of adaptive feeding, 10 rats were randomly selected as the normal group, and other references (Stuart JM, Cremer M A, Townes A S, et al.Type Ⅱ collagen-induced arthritis inrats.Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis[J].Exp Med,1982,155(1):1-16.) Modeling. Take 2g·L -1 Bovine type II collagen was placed in a 4°C refrigerator overnight. with 3.5g·L -1 BCG's complete Freund's adjuvant (CFA) is mixed in equal volumes, fully ground to a milky white viscous liquid, and emulsified, and the final concentration of collagen is 1g L -1 . Intradermally inject 0.3 mL of collagen emulsifier at 2 or 3 points on the back of the rat and 1 at the base of the tail. After 14 days, the inflammation was repeated according to the method and dose of the...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medical composition for treating rheumatoid arthritis and a preparation method and application of the medical composition. The medicine can obviously restrain hyperplasia of synovium of joints and moistening of inflammatory cells of patients suffering from rheumatoid arthritis, can improve vascular proliferation or pannus formation, and cartilage invasion and destroy, can improve the joint damage of the patients, can alleviate arthrocele, and can restrain generation of inflammatory cell factors in serum, so that the medical composition has good treatment effect on the patients suffering from the rheumatoid arthritis.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating rheumatoid arthritis, a preparation method and application thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its main pathological features are joint synovial inflammation and destruction of cartilage and bone tissue. The clinical manifestations are joint pain, stiffness, deformation and even limited mobility. Disabled and disabled. According to statistics, the incidence of RA in the world accounts for 0.1% to 1%, and the prevalence of RA in China is 0.32% to 0.36%. %, is one of the main causes of human loss of labor force and disability. Clinically, non-steroidal anti-inflammatory drugs are commonly used to relieve symptoms, but long-term use has side effects. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutical composition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5025A61P19/02C07D487/14
CPCA61K31/5025C07D487/14
Inventor 宋健
Owner 宋健
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