The application discloses discovery and application of desmin
autoantibody as a marker of
nervous system diseases. The application finds that only the fluorescent
signal existing in the
nervous system disease patients but not in the healthy people, and the fluorescent mode of the IgG related
autoimmune antibody in the mouse
brain tissue section is different, which indicates that the patient may have
autoimmune antibody. Through the
immunoprecipitation technology, the IgG
specific protein related to the
nervous system disease is sought, the specific desmin
autoantibody is found by adopting the CBA mode, and then the desmin
autoantibody is verified in the
cerebrospinal fluid, so that it is finally determined that the desmin autoantibody can be used as a specific marker for diagnosing the nervous
system autoimmune diseases. The expression of the desmin autoantibody is detected by taking the desmin as a detection
antigen, and the detection of the desmin autoantibody can be applied to a kit for detecting the desmin autoantibody, and can be applied to the detection of the nervous
system diseases, so that the marker for identifying the nervous
system diseases is enriched, and the accuracy of the detection of the nervous system related diseases is improved.