The invention discloses clysis fluid for treating the diabetic nephropathy. The clysis fluid is prepared from, by weight, 25-35 parts of rhizoma imperatae, 25-35 parts of fructus kochiae, 15-25 parts of pterocephalus hookeri heck, 25-35 parts of angelica sinensis, 25-35 parts of buddleja lindleyana, 15-25 parts of endothelium corneum gigeriae galli, 15-25 parts of scutellariae barbatae, 5-15 parts of hirudo, 5-15 parts of liquidambar formosana hance, 5-15 parts of flos magnoliae, 15-25 parts of oroxylum indicum vent, 25-35 parts of rhizoma chuanxiong and 5-15 parts of rosa laevigata michx. According to the application, clysis is conducted before users sleep every night, about 200 ml of clysis fluid is used each time, the treatment course includes 15 days, and clysis is conducted twice every day for users suffering from severe symptoms. The clysis fluid can delay the progress of the diabetic nephropathy, can be the important measure for expectant treatment of the diabetic nephropathy azotemia, and has quite high clinical practical value.