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Application of traditional Chinese medicine huanglian jiedu tang in preparing medicament for preventing and treating rheumatoid arthritis

A technology of Huanglian Jiedu Decoction and arthritis, which is used in drug combinations, antipyretics, anti-inflammatory agents, etc., to achieve great clinical application value and the effect of overcoming poisonous effects.

Inactive Publication Date: 2011-05-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no specific therapy for rheumatoid arthritis so far, and it is still in the process of treating inflammation and sequelae.

Method used

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  • Application of traditional Chinese medicine huanglian jiedu tang in preparing medicament for preventing and treating rheumatoid arthritis
  • Application of traditional Chinese medicine huanglian jiedu tang in preparing medicament for preventing and treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0013] 1. Experimental materials

[0014] Drugs and reagents

[0015] Chicken Type II Collagen (CII): Chondrex, Redmond, WA 98052, USA; Incomplete Freund's Complete Adjuvant (IFA) Difco Laboratories, Detroit, MI; Phosphate Buffered Saline (PBS): Prepared by our laboratory, in 800ml Dissolve 8g NaCl, 0.2g KCl, 1.44g Na in distilled water 2 HPO 4 And 0.24g KH 2 PO 4 . Adjust the pH to 7.4 with hydrochloric acid, add water to make the volume to 1L, filter and sterilize before use; DMSO Dimethyl sulfoxide (DMSO): a product of sigma; 1640 medium: Jinuo Biomedical Technology Co., Ltd.; small Bovine serum: Minhai Biological Co., Ltd.; 96-well flat bottom plate, CORNING company; 70μm cell grinding filter, BD Falcon company; 15ml, 50ml centrifuge tube, BD Falcon company; 0.22μm filter, Millipore company; 1ml rotary syringe, BD Company; Braun Tee, Braun Company in Germany; Methotrexate tablets: Shanghai Pharmaceutical (Group) Co., Ltd. Xinyi Pharmaceutical General Factory (080605); Huangli...

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Abstract

The invention provides an application of a traditional Chinese medicine huanglian jiedu decoction (comprising the Chinese medicine components of 9g of coptis chinensis, 6g of scutellaria baicalensis, 6g of golden cypress and 9g of gardenia) in preparing a medicament for preventing and treating rheumatoid arthritis. When being used for animal pharmacodynamic test, the huanglian jiedu decoction is proved to have the functions of restraining the clinical pothogenesy of CIA (Collagen-Induced Arthritis), obviously restraining the severity and the morbidity of the CIA and having obvious protection function to the CIA. The huanglian jiedu decoction can reduce the contents of TNF-alpha, IL-17 and IFN-gamma in splenocyte supernatant and restrain the secretion of proinflammatory cytokine, i.e. TNF-alpha, IFN-gamma and IL-17, thereby playing a protecting role for the CIA disease. The invention provides a new traditional Chinese medicine for clinically treating rheumatoid arthritis, which can overcome the toxic and side effects of pharmaceutical chemicals, thereby bringing confidence for treating and achieving higher clinical application value.

Description

Technical field [0001] The invention relates to traditional Chinese medicine, in particular to the application of Huanglian Jiedu Decoction in preparing medicines for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid Arthritis (RA) is a chronic systemic inflammatory disease whose etiology is unknown. The main clinical manifestations are chronic, symmetrical, polysynovial arthritis and extra-articular lesions, which are autoimmune inflammatory diseases. disease. The disease usually occurs in the small joints of the hands, wrists, feet, etc., with repeated attacks and symmetrical distribution. In the early stage, there are joint swelling, heat, pain and dysfunction. In the late stage, the joints may have different degrees of stiffness and deformity, accompanied by bone and skeletal muscle atrophy, which is extremely disabling. From the point of view of pathological changes, rheumatoid arthritis is a type that mainly affects the synovium of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P19/02A61P19/04A61P29/00
Inventor 张卫东窦圣姗柳润辉刘晓华单磊苏娟沈云亨李慧梁徐希科刘心如
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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