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Application of Houttuynoid C in preparation of medicine for treating rheumatoid arthritis

An arthritic and rheumatoid technology, applied in the application field of Houttuynoid C in the preparation of rheumatoid arthritis drugs, can solve problems such as poor action selectivity, ulcers, damage to gastrointestinal mucosa, etc., achieve outstanding substantive characteristics, inhibit active effect

Inactive Publication Date: 2013-03-27
何晓涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new chemical entity called Orphanodendrochlororhodine B (ODD) was found earlier than any previous molecule discovered previously. It specifically targets small cell lung cancer caused by an autoimmune disease known medically as lupus erythematosus. Its mechanism involves blocking calcium ion channels on certain proteins involved in signal transduction pathways controlling blood clotting processes within joints affected by this condition.

Problems solved by technology

This patented technical problem addressed by this patents relates to finding effective treatments or agents against relapsed forms of rhumatitis caused by an antibiosis used alone without causing side effects such as gastroenteral symptoms like stomach pain.

Method used

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  • Application of Houttuynoid C in preparation of medicine for treating rheumatoid arthritis
  • Application of Houttuynoid C in preparation of medicine for treating rheumatoid arthritis
  • Application of Houttuynoid C in preparation of medicine for treating rheumatoid arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Houttuynoid C tablet involved in the present invention:

[0013] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Houttuynoid C capsule of the present invention:

[0015] Get 20 grams of compound Houttuynoid C, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Houttuynoid C of the present invention on rat adjuvant arthritis

[0018] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the root of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind paw of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Houttuynoid C 5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given diclofenac 10 mg / kg, the control group was given equal volume of distilled water, once a day, for 7 consecutive days...

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Abstract

The invention discloses Houttuynoid C for treating immune-inflammation and the Houttuynoid C is applied to preparing a medicine for treating rheumatoid arthritis. Terfenadine and diclofenac sodium are taken as reference, and the Houttuynoid C is clear in curative effect. The application of Houttuynoid C in preparation of a medicine for treating rheumatoid arthritis is disclosed for the first time, and because the framework type belongs to a novel framework type, the inhibitory activity on the rheumatoid arthritis is unexpectedly high, the possibility that other compounds give enlightenment is avoided, and the Houttuynoid C has outstanding substantial characteristics and has obvious progress in treatment of rheumatoid arthritis.

Description

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Claims

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Application Information

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Owner 何晓涛
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