92results about How to "Suppress pain" patented technology

According to one embodiment, a system for neurological stimulation of peripheral nerve fibers to treat low back pain is provided. The system includes stimulation electrodes adapted to be implanted in tissue proximate a network of peripheral nerve fibers located in and innervating a painful region of the low back area and to deliver electrical stimulation pulses to the network of peripheral nerve fibers located in and innervating the painful region of the low back area. The system also includes a stimulation source adapted for implantation into the person's body and operable to generate electrical stimulation pulses for transmission to the electrodes for delivery to the network of peripheral nerve fibers located in and innervating the painful region of the low back area to relieve pain in the painful region of the low back area.

Extraction devices for extracting analyte through the skin of a living body are disclosed that includes first and second extraction units which are placed on the skin and in which analyte is extracted; electrode unit placed on the skin; and a power source unit for outputting a first current flowing through the electrode unit, the living body, and the first extraction unit, and a second current flowing through the electrode unit, the living body, and the second extraction unit.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

According to one embodiment, a system for neurological stimulation of peripheral nerve fibers to treat low back pain is provided. The system includes stimulation electrodes adapted to be implanted in tissue proximate a network of peripheral nerve fibers located in and innervating a painful region of the low back area and to deliver electrical stimulation pulses to the network of peripheral nerve fibers located in and innervating the painful region of the low back area. The system also includes a stimulation source adapted for implantation into the person's body and operable to generate electrical stimulation pulses for transmission to the electrodes for delivery to the network of peripheral nerve fibers located in and innervating the painful region of the low back area to relieve pain in the painful region of the low back area.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The patch agent of the present invention is a patch agent comprising a support made of a synthetic fiber and an adhesive layer mounted on the support, and having a bending resistance of 10 to 30 mm and a probe tack value of 0.25 to 1.2 N. The patch agent of the present invention can fully be prevented from peeling off at the time of application and can fully suppress the rash of skin and the pain upon peeling.

There is provided a pricking needle which causes less pain upon the pricking operation.The front end portion of the pricking needle is defined by:(1) a rear portion of an ellipse which is formed by cutting through the cylindrical member obliquely ahead from its backward;(2) an isosceles triangle portion that has a central portion of a front edge of the rear portion of the ellipse as a base, that extends forward and obliquely downward from the central portion, and that extends more obliquely downward than a spreading direction of the rear portion of the ellipse;(3) a rightward inclined surface portion and a leftward inclined surface portion, each including an oblique side of the isosceles triangle portion, a side portion of the front edge of the rear portion of the ellipse and a line segment which connects a front apex of the isosceles triangle portion and a distal end of the pricking needle, and extending from the right oblique side of the isosceles triangle obliquely downward; and(4) a portion of a side face of the cylindrical member.

The present invention provides a disposable diaper including an absorber, a top sheet, a back sheet, and a skin contact sheet (SCS) disposed above the top sheet. The skin contact sheet is formed with a stool passing opening and a urine passing opening at a portion corresponding to a crotch part, and includes an SCS central region formed by extending a strip-shaped inter-opening region, which is sandwiched by the two openings and extends in the width direction, by half the length between the openings in the anterior direction and in the posterior direction; an SCS ventral region located at the ventral side from the SCS central region; and an SCS dorsal region located at the dorsal side from the SCS central region. A least the SCS central region has the stretching force in the width direction, and an inter-opening central region sandwiched by the two openings includes a non-stretchable region.

The invention relates to a herpes zoster virus vaccine, and a preparation method and applications thereof, and the herpes zoster virus vaccine is prepared from a varicella-zoster virus glycoprotein Eor a fragment thereof and a compound adjuvant. The compound adjuvant contains a nano-carrier and at least one molecular adjuvant that induces cellular immunity. The vaccine of the present invention iscapable of inducing a strong antibody reaction and a T cell reaction, and can achieve an optimal protective effect with little side effects.

The present application relates at least in part to methods for the administration of small interfering RNAs (siRNAs) to the spinal cord of a human or animal patient and also to a method of treatment for spinal cord injury and other diseases and disorders of the CNS. In particular, the application discloses methods to deliver an siRNA compound locally, directly and without the need for transduction vehicles and formulations in effective doses to the injured spinal cord to promote recovery of CNS function and or attenuation of allodynia.

A patient treatment unit and method analyzes and treats pain in tissues by applying an electrical pulse train and a galvanically isolated stimulus voltage to affected tissues using vibrating spherical tip probes. A range of probe diameters is used to provide a range of applied current densities. The impedance of the affected tissue is measured, tracked, and correlated to a level of pain while treatment is in progress. Impedance is used as real-time feedback, and current and voltage applications are adjusted accordingly. A patient treatment unit includes a probe stimulus generator connected to the spherically tipped probes. The unit further includes an impedance analysis circuit that senses voltage and current via the probes when they are contacting the patient. A monitor is electrically coupled to the body impedance analysis circuit and provides an indication of the measured impedance indicative of the patient's level of pain.

The present invention relates to one kind of externally applied plaster for treating osteoarthrosis caused by wind, cold and damp. The plaster is prepared with clematis root, spatholubus stem, yam rhizome, large-leaf gentian root, ledebouriella root and other Chinese medicinal materials, and through alcohol extraction to obtain extracted solution, adding matrix and other steps. It has the functions of relaxing muscles and tendons, promoting blood circulation, dispersing blood clots, dispelling cold, eliminating wind and damp, etc. It is used in treating arthritis, protrusion of cervical intervertebral disc, protrusion of lumbar intervertebral disc, spur, sciatica, etc. and has high curative effect.

According to one embodiment, a system for neurological stimulation of peripheral nerve fibers to treat low back pain is provided. The system includes stimulation electrodes adapted to be implanted in tissue proximate a network of peripheral nerve fibers located in and innervating a painful region of the low back area and to deliver electrical stimulation pulses to the network of peripheral nerve fibers located in and innervating the painful region of the low back area. The system also includes a stimulation source adapted for implantation into the person's body and operable to generate electrical stimulation pulses for transmission to the electrodes for delivery to the network of peripheral nerve fibers located in and innervating the painful region of the low back area to relieve pain in the painful region of the low back area.

The invention discloses a method for preparing a nano-fiber dressing by virtue of an electrospinning method. The preparing method comprises the following steps: preparing a 0.1g / mL type I collagen solution by taking hexafluoroisopropanol as a solvent, and adding lidocaine, so that outer spinning liquid is obtained; preparing a 0.2g / mL polycaprolactone solution by taking dichloromethane as a solvent, and adding mupirocin, so that inner spinning liquid is obtained; and adding the outer spinning liquid and the inner spinning liquid into two injectors, connecting the two injectors by virtue of a coaxial needle, so that a coaxial structure is formed for conducting high-pressure electrostatic spinning, drying an obtained dressing in a vacuum environment and soaking the dried dressing in an ethanol solution of genipin, washing the dressing with ethanol and drying the dressing, so that the nano-fiber dressing is obtained. The prepared nano-fiber dressing is higher in swelling rate and mechanical strength; the nano-fiber dressing is more suitable to be used as a wet dressing and for absorbing exudation; and the nano-fiber dressing is excellent in long-term use resistance, antibacterial performance and the like.

Orthodontic braces include: a correction frame provided to cover a corresponding group of teeth by having, on an inner surface, a correction recess corresponding to a correct tooth form of teeth, and formed of a soft or hard material; and a support frame tightly coupled to surround an outer surface of the correction frame, and formed of soft or hard material, wherein a coupling groove portion is formed at an edge end portion of an outer surface of the correction frame, and a coupling bent portion correspondingly engaged and coupled to the coupling groove portion is formed at an edge end portion of an inner surface of the support frame.

The invention discloses a formula of traditional Chinese medicines for treating soft tissue injury and a method for preparing a preparation thereof. The formula comprises the following six traditional Chinese medicines in parts by weight according to mixture ratio: 3-9 parts of ceratostigma willmottianum, 1-5 parts of hyacinth bletilla, 1-5 parts of Gaultheria yunnanensis, 0.1-0.5 part of dragon's blood, 0.5-2 parts of turpentine and 0.3-2 parts of borneol which are prepared into an externally-applied traditional Chinese medicine preparation. The prepared externally-applied traditional Chinese medicine preparation is a spraying agent, a tincture, a liniment or a film coating agent. The result of experiments shows that the invention has the advantages of no irritability, no hypersensitivity, quick acting of the medicines, obvious effects of promoting the restoration of the injured soft tissues, resisting inflammation and relieving pain and the like. The preparation prepared by the invention enriches the active components of the medicines highly, has convenient carrying and use and accurate use dose and overcomes the defects of low content of effective components, difficult quality control, poor stability and the like.

The invention discloses an auxiliary rehabilitation device for cardiac surgery nursing and belongs to the technical field of nursing equipment, the device comprises a bed body, and the two sides of the bed body are fixedly connected with the two ends of a fixing rod correspondingly. Two mounting bases are slidably connected to the outer side wall of the fixing rod, adjusting bolts are in threadedconnection with the two mounting bases correspondingly, a sleeve is fixedly connected to one side of each mounting base, a threaded sleeve is connected to the top end of each sleeve in a clamped mode,an adjusting stud is in threaded connection with the interior of each threaded sleeve, and a sleeve is fixedly connected to one side of each mounting base. When a patient lies in a sickbed, the moving block can be pulled downwards by holding the holding frame with hands; the hand of the patient is stretched and recovered under the action of the tension spring, meanwhile, the rotating wheel is rotated, and the adjusting block is pushed to move up and down under the action of the adjusting stud and the threaded sleeve, so that the tension limit of the tension spring is adjusted, the patient canconveniently perform stretching and recovering processes of different strengths, and strength training of the hand is realized.

The invention provides a preparation for treating burn and scald and a method for preparing the same, and belongs to the field of traditional Chinese medicine. The preparation for treating burn and scald has the characteristics of the alleviation of the pain, the inhibition of exudation, anti-infection, quick healing, no scar, no toxic and side effects, low cost and easy treatment. The preparation is prepared from rhizoma corydalis, sanguisorba root, giant knotweed, Chinese goldthread and borneol and can be prepared into powder, salve, water soluble ointment, emulsifiers, spraying agents or powder spraying agents.

The invention discloses medicinal usage of the compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and pharmaceutically acceptable salts thereof, specifically application of the compound and the pharmaceutically acceptable salts thereof in preparing non-steroidal anti-inflammatory and analgesic medicines. According to analgesic and anti-inflammatory tests on mice, after normal administration, the mice have obviously enhanced ability in fighting pain; compared to similar medicines, the compound and the pharmaceutically acceptable salts thereof have a more obvious analgesic effect, have a good inhibition effect on inflammation reactions of animals caused by various factors, and have hypotoxicity according to results of toxicity tests. In a word, the compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and the pharmaceutically acceptable salts thereof have the characteristics of good anti-inflammatory and analgesic activity and hypotoxicity, can be industrially synthesized, are cheap, and can be used individually or jointly with other pharmaceutically acceptable pharmaceutic adjuvants to prepare non-steroidal anti-inflammatory and analgesic medicines, thereby providing a novel means and method for clinical treatment of diseases caused by inflammatory pains and opening up a new direction for clinical administration.

A method of treatment of a diseased patient in which a dose of at least one heavy metal is delivered to the patient, with a surface area which is accessible for direct contact with the patient's tissue and effects release of heavy metal ions for uptake by immuno reactive cells. The criteria to be complied with in order for the heavy metal to be effective is that the surface area is greater than the surface area of a solid sphere of the same at least one heavy metal, and that the solid sphere and dose have the same weight. In a preferred embodiment, the dose of heavy metals is delivered to the patient as very small hollow particles.

The present invention relates to a Chinese medicine adhesive plaster for external application for curing hyperosteogeny effectively. Said Chinese adhesive plaster is made up by using Chinese herbal medicines as raw material and adopting a special preparation process. Said invented Chinese adhesive plaster can obtain obvious and reliable therapeutic effect.

A plaster having a support comprising a synthetic fiber fabric and an adhesive layer laminated on the fabric, characterized in that it has a bending resistance of 10 to 30 mm and a probe tack value of 0.25 to 1.2 N. The plaster allows satisfactory prevention of the exfoliation thereof in being pasted and also satisfactory suppression of a rash and a pain in being peeled.

A method of treatment of a diseased patient in which a dose of at least one heavy metal is delivered to the patient, with a surface area which is accessible for direct contact with the patient's tissue and effects release of heavy metal ions for uptake by immuno reactive cells. The criteria to be complied with in order for the heavy metal to be effective is that the surface area is greater than the surface area of a solid sphere of the same at least one heavy metal, and that the solid sphere and dose have the same weight. In a preferred embodiment, the dose of heavy metals is delivered to the patient as very small hollow particles.

Preparation of nano chitosan in the invention almost has no chemical reaction, chitosan is mainly dissolved and dispersed, and chitosan is not dissolved in a sodium hydroxide solution, so that chitosan particles are separated out. Meanwhile, preparation conditions are mild, the safety is high, and preparation raw materials are common and nontoxic. The obtained nano chitosan is an ideal raw material for preparing artificial skin, the prepared artificial skin is soft in texture and is comfortable, the laminating performance between the prepared artificial skin and a wound surface is good, and the prepared artificial skin is breathable, can absorb water, has antibacterial and anti-inflammatory effects, and has the functions of stopping pain, arresting bleeding and promoting wound healing. Along with the healing of the wound of a patient and the growth of the skin of the patient, the chitosan artificial skin can be automatically dissolved and absorbed by the body, scraps cannot be left so as to avoid the delay of wound healing, and skin regeneration can be promoted. Moreover, the operation is simple, the safety is improved, and preparation processes are simplified. Required instruments are relatively common so as to be favorable for reducing the cost, and thus the nano chitosan has important application value in the field of artificial skin.

The invention provides a zipper-type medical dressing provided with an electret. The medical dressing is constituted by closely sticking a protective layer, a silicone gel layer, a liquid-absorbent layer and a zipper layer sequentially from bottom to top, wherein a three-dimensional hollow cavity is defined between the silicone gel layer and the zipper layer; the liquid-absorbent layer is arrangedin the three-dimensional hollow cavity; and the liquid-absorbent layer can be optionally replaced or detached. According to the medical dressing provided by the invention, different functions are provided in accordance with the demands in various healing periods of a wound surface, so that the healing of the wound surface is promoted. The medical dressing provided by the invention has an electreteffect, and moreover, the medical dressing is excellent in liquid-absorbing performance, antibacterial property, scar removal performance and air permeability; and the medical dressing can take an obvious effect on treating chronic wounds.

The invention discloses a traditional Chinese medicinal compound preparation for treating heart heat internal disturbance type night cry, and a preparation method and an application thereof. The preparation comprises, by weight, 2-40 parts of honeysuckle flower, 2-40 parts of Rhizoma Coptidis and 2-40 parts of common rush. Above components can be respectively extracted and then mixed, and can also be mixed and then extracted; an extraction solvent can be water or 10-95% ethanol; and an extraction method is a routine traditional Chinese medicine extraction method. The above medicinal composition prepared in the invention can be processed through routine methods to prepare various oral preparations used for treating heart heat internal disturbance type night cry. The traditional Chinese medicinal compound preparation for treating heart heat internal disturbance type night cry can clear heat and detoxify, and is used for reducing heart heat, dispelling fetal toxicity, dispel blood stasis, and treating upset, insomnia and children's night cry.

The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

The invention provides a preparation method of a biological matrix gel material for promoting regeneration and repair of cartilage, a gel performance determination method and application. The steps include: adding a GP solution into a mixed solution of a human amniotic membrane-PEI system and a mixed solution of a chitosan solution to conduct blending treatment to obtain a chitosan / human amniotic membrane-PEI / GP system mixed solution with the biological matrix gel material as the matrix. The gel formed by the chitosan solution and the GP solution maintains the activity of cells in the mixed solution of the human amniotic membrane-PEI system, promotes the regeneration and repair of cartilage, and artificial joint replacement is no longer carried out for treatment, therefore, the non-surgical treatment effect of severe osteoarthritis formed by further development of cartilage injury is improved.

An ultrasonic medical treatment device has a probe, a transducer for mechanically vibrating the probe at an ultrasonic frequency, a voltage source for energizing the transducer, and another electrical voltage source for feeding to the probe a high-frequency alternating waveform of limited current and limited voltage to be conducted into a patient through the operative tip of the probe after placement of the operative tip into contact with the patient. The alternating waveform has a current and a voltage so limited as to prevent damage to organic tissues while stimulating nerves to reduce or suppress pain.