Application of compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and pharmaceutically acceptable salt thereof in preparing non-steroidal anti-inflammatory and analgesic medicines

Abstract

The invention discloses medicinal usage of the compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and pharmaceutically acceptable salts thereof, specifically application of the compound and the pharmaceutically acceptable salts thereof in preparing non-steroidal anti-inflammatory and analgesic medicines. According to analgesic and anti-inflammatory tests on mice, after normal administration, the mice have obviously enhanced ability in fighting pain; compared to similar medicines, the compound and the pharmaceutically acceptable salts thereof have a more obvious analgesic effect, have a good inhibition effect on inflammation reactions of animals caused by various factors, and have hypotoxicity according to results of toxicity tests. In a word, the compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and the pharmaceutically acceptable salts thereof have the characteristics of good anti-inflammatory and analgesic activity and hypotoxicity, can be industrially synthesized, are cheap, and can be used individually or jointly with other pharmaceutically acceptable pharmaceutic adjuvants to prepare non-steroidal anti-inflammatory and analgesic medicines, thereby providing a novel means and method for clinical treatment of diseases caused by inflammatory pains and opening up a new direction for clinical administration.

Description

technical field

[0001] The invention belongs to the field of completely new compound applications, and specifically relates to the application of the compound 4-o-toluenesulfonyloxybenzoxazolone and its pharmaceutically acceptable salts in the preparation of non-steroidal anti-inflammatory and analgesic drugs. Background technique

[0002] The research on non-steroidal anti-inflammatory analgesic drugs is a research hotspot in the field of drug research. These drugs have anti-inflammatory, anti-rheumatic, analgesic, antipyretic and anti-coagulant effects, and are widely used clinically for osteoarthritis, Relief of rheumatoid arthritis, multiple fevers, and various pain symptoms. There are many kinds of non-steroidal anti-inflammatory analgesic drugs, mainly divided into six categories: pyrazolidinedione, anthranilic acid, aryl alkanoic acid, aryl propionic acid, 1,2-benzothiazine (Oxicam class) and other classes (mainly including COX-2 inhibitors). Most of these drugs hav...

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