43 results about "Alkanoic acid" patented technology

Provided are a recombinant human interleukin-11 mutant, and a conjugate of the mutant conjugated to a chemical molecule and a use thereof. The recombinant human interleukin-11 mutant achieves soluble expression in an Escherichia coli expression system by means of an SUMO sequence tandem fusion method. The conjugate is obtained by the site-specific conjugation of the mutant to the chemical molecule at a mutant amino acid residue in position W147 by means of a covalent bond. The chemical molecule is at least one of polyethylene glycol, an alkanoic acid aliphatic chain, and a hydrophilic high-molecular polymer containing an alkanoic acid aliphatic chain. The conjugate retains the binding capacity to human interleukin-11 receptor A while demonstrating significantly reduced binding capacity to human IL-6 signal transducer receptor. The conjugate shows the ability to block the signaling between human IL-11 and IL-11 RA and between human IL-11 and GP130 either in vivo or in vitro and can be used for the treatment of associated diseases with tissue fibrosis as a clinical manifestation caused by elevated primary or secondary IL-11.

The invention provides a method for preparing diglyceride oil by a solventless enzymatic method, which comprises the following steps: S1, mixing saturated fatty acid A and saturated fatty acid B to prepare a liquid eutectic mixture; s2, mixing the eutectic mixture, glycerol and lipase in a reaction system, and carrying out esterification reaction to obtain diglyceride; s3, separating the prepared diglyceride, adding the saturated fatty acid A and / or the saturated fatty acid B into the reaction system again to form a liquid eutectic mixture again, and repeating the step 2; wherein in the step S1, the saturated fatty acid A and the saturated fatty acid B are selected from C10-C20 alkanoic acid, in the step S2, the mass ratio of the eutectic mixture to the glycerol is 1: (1-5), and the temperature of the esterification reaction is 35-78 DEG C. The method solves the problem that the high-melting-point saturated fatty acid is difficult to utilize in the existing technology for preparing the diglyceride oil by the solvent-free enzymatic method.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

The present invention relates to a novel separation process for preparing an extract of Arnebia root having a reduced pyrrolizidine alkaloid content by liquid-liquid chromatography (LLC) using a biphasic binary solvent system obtained by partially mixing a polar organic solvent with water acidified with a strong organic acid, the polar organic solvent is selected from the group consisting of fatty alcohols having 4 to 5 carbon atoms and alkanoates having 3 to 6 carbon atoms.

Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic assembly may include a first die having a surface; a second die having a first surface, an opposing second surface, and side surfaces between the first surface and the second surface, wherein the first surface of the second die is electrically coupled to the surface of the first die, and wherein the side surfaces of the second die are scalloped. In some embodiments, side surfaces of the second die may include a protective coating material, where the protective coating material includes an alkyl silane, a fluoroalkyl silane, a thiol, a phosphonic acid, an alkanoic acid, a siloxane, a silazane, a polyolefin, or a fluorinated polymer. In some embodiments, a microelectronic assembly may further include a dielectric material around a plurality of second dies and the dielectric material does not have an interface seam.

This invention relates to the biotechnological production of ω-functionalized carboxylic acids and their esters. Microbial cells are provided for the production of at least one ω-functionalized carboxylic acid ester from at least one alkane, wherein the cells are genetically modified relative to wild-type cells to increase the expression of: (i) an enzyme E1 capable of converting the alkane to the corresponding 1-alkanol; (ii) an enzyme E2 capable of converting the 1-alkanol of (i) to the corresponding 1-alkanal; (iii) an enzyme E3 capable of converting the 1-alkanal of (ii) to the corresponding alkanoic acid; (iv) an enzyme E4 capable of converting the alkanoic acid of (iii) to the corresponding alkanoic acid ester; and (iv) an enzyme E5 capable of converting the alkanoic acid ester of (iv) to the corresponding ω-hydroxy-alkanoic acid ester, and wherein the cells do not contain an increase relative to wild-type cells of the expression of the following enzymes selected from the group consisting of: 20 -E 24 Genetic modification of expression of at least one of them: -E 20 Acyl-ACP thioesterase, -E 21 Acyl-CoA thioesterase, -E 22 Acyl-CoA:ACP transacylase, -E 23 Polyketide synthase, and -E 24 Hexanoic acid synthase.

There is provided a hair styling polymer comprising: from 70% to 95% by weight, based on dry polymer, of a vinyl alkanoate monomer having from 4 to 13 carbons; from 5% to 30% by weight, based on dry polymer, of a carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbons; from 0% to 5% by weight, based on dry polymer, of a polyethylenically unsaturated crosslinker; from 0% to 20% by weight, based on dry polymer, of a further monoethylenically unsaturated monomer wherein the further monoethylenically unsaturated monomer is different from the alkanoic acid vinyl ester monomer having from 4 to 13 carbon atoms and the carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms; wherein the hair styling polymer comprises lt based on dry polymer; 15% by weight of a monoethylenically unsaturated C4-6 dicarboxylic acid monomer; and wherein the hair styling polymer comprises at least two different alkanoic acid vinyl ester monomers having from 4 to 13 carbons.

Provided in the present invention is a poly(3-hydroxybutyrate) polymer derivative, having a structure as represented by formula (I), wherein A is phenyl or phenyl C1-C4 alkyl, optionally substituted with a substituent selected from hydroxyl, C1-C4 alkyl, and C2-C4 alkenyl, R is saturated C1-C4 alkyl or hydroxyl-substituted saturated C1-C4 alkyl, Z is a polymeric residue of a hydroxy C3-C10 alkanoic acid, x is an integer from 1 to 20, and y is an integer from 0 to 20. Compared with an unmodified 3-hydroxybutyrate polymer, the poly(3-hydroxybutyrate) polymer derivative provided by the present invention has a significantly improved aromatic odor while retaining excellent broad-spectrum antimicrobial / antiviral effects of a poly(3-hydroxybutyrate) polymer, can also degrade under natural conditions, and has no irritation to the skin.

The present invention is related to the use of ethylene alkanoate-alkyl acrylate bipolymers with a high randomness monomers distribution, which are synthesized by semicontinuous emulsion polymerization process, characterized because it is carried out using slow addition rate of the pre-emulsion feeding ({dot over (q)}≤0.009 kg·L−1·min−1), stabilized this last one by alkyl glycol ether type surfactants, at temperatures higher than 75° C. and with solids contents above 25 wt %, which avoids the formation of large sequences (blocks) of a same monomer. This structural characteristic gives the ethylene alkanoate-alkyl acrylate bipolymers a high efficiency as chemical agents for removal of complex water / crude oil emulsions of crude oil blends.

The disclosure relates to synthetic wax compositions including at least one long- chain hydrocarbon residue having 4 to 40 carbon atoms, and at least one oligomeric residue containing 4 to 50 ester units such as adipate-co-terephthalate units, alkanoate units, glycolic acid units, and / or lactic acid units. The synthetic wax can include other functional groups such as pendant carboxylic groups to facilitate emulsification and / or metal complexation of the wax, and / or unsaturated carbon-carbon double bonds to facilitate curing or crosslinking of the wax. The synthetic wax can be used as a coating on a variety of substrates, for example paper substrates, to impart water and / or oil resistance to the substrate. The presence of the carboxylic groups and / or oligomeric ester residue in the wax permits chemical degradation under very mild conditions, which in turn facilitates removal, repulping, and / or recycling of the synthetic wax.

The invention relates to a cosmetic or dermatological preparation comprising a) one or more alkylamidothiazoles, and b) one or more substances selected from the group consisting of: ba) C5-C25-triglycerides, bb) isopropyl esters of branched or linear C14-C26 alkanoic acids, bc) esters of branched C6-C16 alkanols with branched or linear C14-C26 alkanoic acids, c) and / or any mixture of them, d) in a cosmetic or dermatological formulation containing no more than 10% by weight of water, preferably no more than 5% by weight of water, in particular preferably no more than 1% by weight of water, ideally completely water-free.

The invention discloses a preparation method and application of a 1, 2, 4-oxadiazole compound containing a camphor alkanoic acid group, and the structural formula of the 1, 2, 4-oxadiazole compound containing the camphor alkanoic acid group is shown in the specification. According to the application of the camphor alkanoic acid group-containing 1, 2, 4-oxadiazole compound in prevention and treatment of agricultural meloidogyne incognita, the activity result shows that the compound provided by the invention has a relatively good prevention and treatment effect on the meloidogyne incognita and sclerotinia rot of colza.

The present application relates to the technical field of paint, and disclose a kind of preparation method of waterproof weatherable water-based paint for road, 100 parts by weight water-based epoxy resin, 2-5 parts by weight 2,4-diamino alkanoic acid-6-(2,4-dihydroxyphenyl)-1,3,5-triazine, 1-5 parts by weight modified silicon dioxide etc. are mixed, to obtain waterproof weatherable water-based paint for road.Epoxy resin coating in thermal curing process, the carboxyl group of 2,4-diamino alkanoic acid-6-(2,4-dihydroxyphenyl)-1,3,5-triazine can participate in the curing reaction of epoxy resin, play good toughening effect, reduce water absorption, improve the ultraviolet resistance and weatherability.Nano-silica is modified, and the dispersibility and compatibility in coating are better, can play better reinforcing and toughening effect, and be conducive to improving the impact strength and bending strength of coating.

The invention discloses a long-chain ethylenediamine bis-n-alkanoic acid diammonium salt single-crystal phase change material and a preparation method thereof, ethylenediamine is used as an alkaline ligand, long-chain n-alkanoic acid is used as an acidic ligand, and the long-chain n-alkanoic acid is introduced to amino groups at two ends of ethylenediamine through a salt forming reaction to form the long-chain single-crystal phase change material with a sandwich layered structure. The structural formula of the material is [NH3 (CH2) 2NH3] < 2 + >. 2 [RCOO] <->, wherein R represents C11-C15 linear alkyl; the single crystal is regular in structure and belongs to a triclinic system and a P1 space group, and Z is equal to 1. The narrow phase change temperature zone and the phase change enthalpy of the material are averagely improved by more than 30% and can be maximally improved by more than 80% compared with corresponding long-chain n-alkanoic acid, and the material has good thermodynamic properties and is expected to be applied to the fields of industrial waste heat recovery, solar heat storage, aerospace thermal control systems and the like as an efficient phase change energy storage material.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

Cosmetic or dermatological preparations containing a) one or more alkylamidothiazoles and b) one or more substances selected from the group of ba) C 5 - C 25 - Triglyceride bb) the isopropyl ester of the branched or unbranched C 14 - C 26 -alkanoic acids bc) the esters of the branched C 6 - C 16 -alkanols and the branched or unbranched C 14 - C 26 -alkanoic acids c) and / or any mixtures thereof d) in cosmetic or dermatological preparations which contain not more than 10% by weight of water, preferably not more than 5% by weight of water, particularly preferably not more than 1% by weight and ideally are completely anhydrous.

An enzymatic method and system for producing a bioplastic polymer from a used product containing a thermoplastic polymer is disclosed. The thermoplastic polymer-containing product after use can be pyrolyzed to obtain a combined liquor of depolymerized alkanes. The combined liquid of alkanes may be contacted in vitro with an enzyme or a mixture of enzymes to produce a bioplastic polymer.

This aliphatic polyester film contains at least a polyhydroxy alkanoic acid and has a property such that the half width Hh of a height distribution histogram as determined by AFM measurement of a film cross section obtained with a rotary microtome is 5 nm to 60 nm inclusive. Provided is an aliphatic polyester film of which the disintegration start timing during biodegradation is shortened, thereby enhancing the treatment efficiency of composting at home (hereinafter, referred to as "home composting"), and which can also be suppressed from undergoing deterioration in quality, such as formation of wrinkles, when processed into a packaging material or a material for agricultural, forestry and fishery uses.

Provided are a recombinant human interleukin-11 mutant, and a conjugate of the mutant conjugated to a chemical molecule and a use thereof. The recombinant human interleukin-11 mutant achieves soluble expression in an Escherichia coli expression system by means of an SUMO sequence tandem fusion method. The conjugate is obtained by the site-specific conjugation of the mutant to the chemical molecule at a mutant amino acid residue in position W147 by means of a covalent bond. The chemical molecule is at least one of polyethylene glycol, an alkanoic acid aliphatic chain, and a hydrophilic high-molecular polymer containing an alkanoic acid aliphatic chain. The conjugate retains the binding capacity to human interleukin-11 receptor A while demonstrating significantly reduced binding capacity to human IL-6 signal transducer receptor. The conjugate shows the ability to block the signaling between human IL-11 and IL-11 RA and between human IL-11 and GP130 either in vivo or in vitro and can be used for the treatment of associated diseases with tissue fibrosis as a clinical manifestation caused by elevated primary or secondary IL-11.

The present invention relates to a method of extracting an alkanoic acid and / or ester thereof from an aqueous medium, the method comprising:(a) contacting the alkanoic acid and / or ester thereof in the aqueous medium with at least one extracting medium for a time sufficient to extract the alkanoic acid and / or ester thereof from the aqueous medium into the extracting medium,(b) separating the extracting medium with the extracted alkanoic acid and / or ester thereof from the aqueous mediumwherein the extracting medium comprises:a mixture of at least one alkyl-phosphine oxide, preferably Trioctylphosphine oxide (TOPO), and at least one alkanewherein the alkane comprises at least 12 carbon atoms.

The application provides a method for preparing diglyceride oil by a solvent-free enzyme method, comprising the following steps: S1, mixing saturated fatty acid A and saturated fatty acid B to prepare a liquid eutectic mixture; S2, mixing the eutectic mixture, glycerol and lipase in a reaction system to perform esterification to obtain diglyceride; S3, separating the prepared diglyceride, and adding the saturated fatty acid A and / or the saturated fatty acid B into the reaction system again to form a liquid eutectic mixture again, and repeating step 2; wherein in S1, the saturated fatty acid A and the saturated fatty acid B are both selected from C10-C20 alkanoic acid, in S2, the mass ratio of the eutectic mixture to the glycerol is 1:(1-5), and the temperature of the esterification is 35-78 DEG C. The application solves the problem that high-melting-point saturated fatty acid is difficult to use in the prior art of preparing diglyceride oil by a solvent-free enzyme method.

This invention discloses a comprehensive recycling method for byproducts of alkyl dichlorophosphine production. The method includes: reacting an alkanoic acid compound with the alkyl dichlorophosphine in the byproduct to generate a phosphorus-containing flame retardant or its intermediate, obtaining a post-reaction mixture; then, gradually separating sodium chloride and precipitates in the form of hydrated aluminum trichloride by progressively increasing the hydrogen chloride content in the system, obtaining a mixture containing the phosphorus-containing flame retardant or its intermediate, a small amount of aluminum chloride, sodium chloride, and hydrochloric acid; distilling and concentrating the mixture, adding sodium hydroxide, filtering, acidifying and concentrating the filtrate, and then extracting and purifying. This method yields pure sodium chloride, pure hydrated aluminum chloride, and the phosphorus-containing flame retardant or its intermediate. The steps are clear, the function is well-defined, and the method is simple and easy to control, completely solving the problem of comprehensive utilization of complex salts in the production of methyl dichlorophosphine.

There is provided a hair styling polymer comprising: a cosmetically acceptable carrier; and a hair styling polymer comprising: 70% to 95% by weight, based on the dry polymer, of a monoethylenically unsaturated vinyl alkanoate monomer having 4 to 13 carbon atoms; from 5% to 30% by weight, based on the dry weight of the hairstyling polymer, of structural units of a monoethylenically unsaturated carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms; from 0% to 5% by weight, based on the dry weight of the hair styling polymer, of structural units of a polyethylenically unsaturated crosslinking monomer; and 0% to 20% by weight, based on the dry weight of the hairstyling polymer, of structural units of other monoethylenically unsaturated monomers, wherein the further monoethylenically unsaturated monomer is different from the monoethylenically unsaturated alkanoic acid vinyl ester monomer having from 4 to 13 carbon atoms and the monoethylenically unsaturated carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms.

This invention relates to a lubricating composition comprising or resulting from the admixing of: base oil, detergent, and one or more metal alkanoates having a quaternary carbon atom at the 2 position, the 2′ position, or both the 2 and 2′ positions, where the lubricating composition preferably has an adhesive wear of 100 hours or more, a foam volume of 70 ml or less at 24° C., and 50 ml or less at 93.5° C., and, optionally, a total base number of 7 mgKOH / g or more.

This invention relates to the use of colloids of a core of zinc containing compounds and a shell of metal containing surfactants, such as salicylates and or sulfonates, metal alkanoates, and or metal carboxylates, as additives in lubricant compositions having good anti-wear properties, especially for engine crankcase applications.

【Solution】 The present invention provides a method for coloring and surface-treating the surface of particulate materials such as sand (e.g., silica-based materials such as sand). The method comprises a) optionally heating the particulate material to a temperature of 30°C to 85°C; b) preparing an aqueous dispersion of a colorant, an alkoxysilane, a silyl alkanate, a polysiloxane, or a mixture thereof; c0) optionally treating the particulate material, c1) mixing the dispersion prepared in step b) with the particulate material of step a); c2) optionally adding an alkoxysilane, a silyl alkanate, a polysiloxane, or a mixture thereof; c3) heating the mixture at a temperature of 20°C to 80°C for 1 minute to 24 hours; and d) optionally mixing the treated sand formed in step c) with an aqueous dispersion of a colorant, an alkoxysilane, a silyl alkanate, a polysiloxane, or a mixture thereof. Steps a) (if used) and b) may be carried out simultaneously or sequentially, in any order. At least one step involves the use of an alkoxysilane, a silyl alkanate, and / or a polysiloxane. At least one step involves the use of a colorant. The aqueous dispersion in step d) may be the same as or different from that in step b). The present invention further provides a colored particulate material having at least one surface surface-modified with a colorant and at least one silylalkyl group or silylalkenyl group. The material can be produced by the method of the present invention. The present invention also provides a filled molding material comprising the colored particulate filler material.

The invention relates to an electrolyte comprising alkyl alkanoates, ketones and / or nitriles as main organic solvents for batteries for recycling lithium ions. A lithium ion circulating battery includes an electrolyte including an organic solvent and a lithium salt in the organic solvent. The organic solvent comprises greater than or equal to 70% by weight of a primary solvent comprising alkyl alkanoates, ketones, nitriles, or a combination thereof. The electrolyte is advantageously useful in a battery comprising a positive electrode comprising an electroactive material comprising a layered nickel-rich lithium transition metal oxide.

The present invention mainly relates to a process for the production of omega-aminoalkanoic acids of formula NH2-(CH2)n-COOH n by reacting the corresponding omega-bromoalkanoic acids with ammonia, wherein n is an integer from 9 to 11, which process comprises the following steps: i) reacting said omega-bromoalkanoic acids with an excess of aqueous ammonia solution, and ii) isolating the omega-aminoalkanoic acids formed from the reaction mixture, characterized in that the aqueous ammonia solution has a concentration of 35 to 70 wt.-%, and in that phase i) is carried out at a pressure higher than atmospheric pressure, at a pressure of 0.11 to 2.0 MPa absolute.

The invention relates to the technical field of coatings, and discloses a preparation method of a waterproof and weather-resistant water-based coating for roads, and the waterproof and weather-resistant water-based coating for the roads is obtained by mixing 100 parts by weight of water-based epoxy resin, 2-5 parts by weight of 2, 4-diaminoalkanoic acid-6-(2, 4-dihydroxyphenyl)-1, 3, 5-triazine, 1-5 parts by weight of modified silicon dioxide and the like. In the thermocuring process of the epoxy resin coating, carboxyl of 2, 4-diamino alkanoic acid-6-(2, 4-dihydroxyphenyl)-1, 3, 5-triazine can participate in the curing reaction of epoxy resin, a good toughening effect is achieved, the water absorption rate is reduced, and the ultraviolet resistance and weather resistance are improved. After being modified, the nano silicon dioxide has better dispersity and compatibility in the coating, can play better reinforcing and toughening roles, and is beneficial to improving the impact strength and bending strength of the coating.

A catalyst and a preparation method therefor, and a method for preparing an olefinic unsaturated acid or an ester thereof. The catalyst comprises a carrier and catalytic metal loaded on the carrier, wherein the carrier is a composite of silicon dioxide and mesoporous boron nitride. Furthermore, in the presence of the catalyst, an alkanoic acid or alkanoate having a general formula of R1-CH2-COOR2 reacts with formaldehyde to obtain an olefinic unsaturated acid or an ester thereof, wherein R1 and R2 are independently selected from hydrogen or alkyl.