57 results about "Alkanoic acid" patented technology

Provided are a recombinant human interleukin-11 mutant, and a conjugate of the mutant conjugated to a chemical molecule and a use thereof. The recombinant human interleukin-11 mutant achieves soluble expression in an Escherichia coli expression system by means of an SUMO sequence tandem fusion method. The conjugate is obtained by the site-specific conjugation of the mutant to the chemical molecule at a mutant amino acid residue in position W147 by means of a covalent bond. The chemical molecule is at least one of polyethylene glycol, an alkanoic acid aliphatic chain, and a hydrophilic high-molecular polymer containing an alkanoic acid aliphatic chain. The conjugate retains the binding capacity to human interleukin-11 receptor A while demonstrating significantly reduced binding capacity to human IL-6 signal transducer receptor. The conjugate shows the ability to block the signaling between human IL-11 and IL-11 RA and between human IL-11 and GP130 either in vivo or in vitro and can be used for the treatment of associated diseases with tissue fibrosis as a clinical manifestation caused by elevated primary or secondary IL-11.

The invention provides a method for preparing diglyceride oil by a solventless enzymatic method, which comprises the following steps: S1, mixing saturated fatty acid A and saturated fatty acid B to prepare a liquid eutectic mixture; s2, mixing the eutectic mixture, glycerol and lipase in a reaction system, and carrying out esterification reaction to obtain diglyceride; s3, separating the prepared diglyceride, adding the saturated fatty acid A and / or the saturated fatty acid B into the reaction system again to form a liquid eutectic mixture again, and repeating the step 2; wherein in the step S1, the saturated fatty acid A and the saturated fatty acid B are selected from C10-C20 alkanoic acid, in the step S2, the mass ratio of the eutectic mixture to the glycerol is 1: (1-5), and the temperature of the esterification reaction is 35-78 DEG C. The method solves the problem that the high-melting-point saturated fatty acid is difficult to utilize in the existing technology for preparing the diglyceride oil by the solvent-free enzymatic method.

The present invention provides biodegradable composite materials comprising: a) a polymeric matrix comprising about 50-80% by weight of a cellulose alkanoate; about 0.1 to 10% by weight of a polyester, wherein the polyester is an aliphatic-aromatic copolyester, an aliphatic polyester, or a mixture of an aliphatic polyester and thermoplastic starch; about 10 to 20% by weight of a plasticizer; about 10 to 20% by weight of a flame-retardant component; optionally an inorganic filler; and b) a fibrous reinforcement material.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

Disclosed are two different groups of block copolymers having the general structure (I) or (III), compositions thereof, and methods of using these compositions in DSA; wherein the B fragment and the B1 fragment are polar block copolymer fragments comprising a 2-methylene alkanoic acid alkyl ester-derived repeat unit, a lactone-derived repeat unit, an ethylene oxide-derived repeat unit, an oxetane or cyclic carbonate-derived repeat unit; l and L1 are a direct valence bond or a linking moiety derived from 1, 1-diarylethene; fragments A and A1 are non-polar block copolymer fragments comprising styrenic repeat units, E ', E' ', E3 and E4 are different types of end groups, A2 is a block fragment derived from an olefinic hydrocarbon or diene having a Tg of from about-5 DEG C to about-50 DEG C, and in structure (I), is multi-linked by an oligomeric flexible tether group at different positions as summarized: E'-A-L-B-E ''(I) E3-A1-A2-L1-B1-E4 (III).

The invention discloses fluocinolone hydroquinone tretinoin acid cream and a preparation method of the fluocinolone hydroquinone tretinoin acid cream. The invention provides a preparation method of fluocinonehydroquinone tretinoin emulsifiable paste, which comprises the following steps: S02, preparing an oil phase: mixing fatty glyceride, a fatty alcohol mixture, C12-C20 alkanoic acid and polyoxyethylene (35) castor oil, adding tretinoin, and then adding liquid alkane; s031, at the temperature of 60 DEG C to 80 DEG C, a pH regulator, polyhydric alcohol and the magnesium aluminum silicate gel are mixed; mixing with the oil phase in S02, stirring and emulsifying; and S032, mixing the product obtained in the step S031 with an antioxidant, fluocinonide and hydroquinone, stirring, and emulsifying. By improving the existing preparation method, the tretinoin can be effectively prevented from crystallizing, and the content uniformity of the tretinoin can be improved.

The present invention relates to a novel separation process for preparing an extract of Arnebia root having a reduced pyrrolizidine alkaloid content by liquid-liquid chromatography (LLC) using a biphasic binary solvent system obtained by partially mixing a polar organic solvent with water acidified with a strong organic acid, the polar organic solvent is selected from the group consisting of fatty alcohols having 4 to 5 carbon atoms and alkanoates having 3 to 6 carbon atoms.

Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic assembly may include a first die having a surface; a second die having a first surface, an opposing second surface, and side surfaces between the first surface and the second surface, wherein the first surface of the second die is electrically coupled to the surface of the first die, and wherein the side surfaces of the second die are scalloped. In some embodiments, side surfaces of the second die may include a protective coating material, where the protective coating material includes an alkyl silane, a fluoroalkyl silane, a thiol, a phosphonic acid, an alkanoic acid, a siloxane, a silazane, a polyolefin, or a fluorinated polymer. In some embodiments, a microelectronic assembly may further include a dielectric material around a plurality of second dies and the dielectric material does not have an interface seam.

This invention relates to the biotechnological production of ω-functionalized carboxylic acids and their esters. Microbial cells are provided for the production of at least one ω-functionalized carboxylic acid ester from at least one alkane, wherein the cells are genetically modified relative to wild-type cells to increase the expression of: (i) an enzyme E1 capable of converting the alkane to the corresponding 1-alkanol; (ii) an enzyme E2 capable of converting the 1-alkanol of (i) to the corresponding 1-alkanal; (iii) an enzyme E3 capable of converting the 1-alkanal of (ii) to the corresponding alkanoic acid; (iv) an enzyme E4 capable of converting the alkanoic acid of (iii) to the corresponding alkanoic acid ester; and (iv) an enzyme E5 capable of converting the alkanoic acid ester of (iv) to the corresponding ω-hydroxy-alkanoic acid ester, and wherein the cells do not contain an increase relative to wild-type cells of the expression of the following enzymes selected from the group consisting of: 20 -E 24 Genetic modification of expression of at least one of them: -E 20 Acyl-ACP thioesterase, -E 21 Acyl-CoA thioesterase, -E 22 Acyl-CoA:ACP transacylase, -E 23 Polyketide synthase, and -E 24 Hexanoic acid synthase.

There is provided a hair styling polymer comprising: from 70% to 95% by weight, based on dry polymer, of a vinyl alkanoate monomer having from 4 to 13 carbons; from 5% to 30% by weight, based on dry polymer, of a carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbons; from 0% to 5% by weight, based on dry polymer, of a polyethylenically unsaturated crosslinker; from 0% to 20% by weight, based on dry polymer, of a further monoethylenically unsaturated monomer wherein the further monoethylenically unsaturated monomer is different from the alkanoic acid vinyl ester monomer having from 4 to 13 carbon atoms and the carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms; wherein the hair styling polymer comprises lt based on dry polymer; 15% by weight of a monoethylenically unsaturated C4-6 dicarboxylic acid monomer; and wherein the hair styling polymer comprises at least two different alkanoic acid vinyl ester monomers having from 4 to 13 carbons.

Provided in the present invention is a poly(3-hydroxybutyrate) polymer derivative, having a structure as represented by formula (I), wherein A is phenyl or phenyl C1-C4 alkyl, optionally substituted with a substituent selected from hydroxyl, C1-C4 alkyl, and C2-C4 alkenyl, R is saturated C1-C4 alkyl or hydroxyl-substituted saturated C1-C4 alkyl, Z is a polymeric residue of a hydroxy C3-C10 alkanoic acid, x is an integer from 1 to 20, and y is an integer from 0 to 20. Compared with an unmodified 3-hydroxybutyrate polymer, the poly(3-hydroxybutyrate) polymer derivative provided by the present invention has a significantly improved aromatic odor while retaining excellent broad-spectrum antimicrobial / antiviral effects of a poly(3-hydroxybutyrate) polymer, can also degrade under natural conditions, and has no irritation to the skin.

The present invention is related to the use of ethylene alkanoate-alkyl acrylate bipolymers with a high randomness monomers distribution, which are synthesized by semicontinuous emulsion polymerization process, characterized because it is carried out using slow addition rate of the pre-emulsion feeding ({dot over (q)}≤0.009 kg·L−1·min−1), stabilized this last one by alkyl glycol ether type surfactants, at temperatures higher than 75° C. and with solids contents above 25 wt %, which avoids the formation of large sequences (blocks) of a same monomer. This structural characteristic gives the ethylene alkanoate-alkyl acrylate bipolymers a high efficiency as chemical agents for removal of complex water / crude oil emulsions of crude oil blends.

The disclosure relates to synthetic wax compositions including at least one long- chain hydrocarbon residue having 4 to 40 carbon atoms, and at least one oligomeric residue containing 4 to 50 ester units such as adipate-co-terephthalate units, alkanoate units, glycolic acid units, and / or lactic acid units. The synthetic wax can include other functional groups such as pendant carboxylic groups to facilitate emulsification and / or metal complexation of the wax, and / or unsaturated carbon-carbon double bonds to facilitate curing or crosslinking of the wax. The synthetic wax can be used as a coating on a variety of substrates, for example paper substrates, to impart water and / or oil resistance to the substrate. The presence of the carboxylic groups and / or oligomeric ester residue in the wax permits chemical degradation under very mild conditions, which in turn facilitates removal, repulping, and / or recycling of the synthetic wax.

The invention discloses a heat-resistant complex iron desulfurizer and a preparation method and application thereof, and relates to the technical field of desulfurizers. The heat-resistant complex iron desulfurizer is obtained by chelating n-alkanoic acid-modified carboxymethyl chitosan, fulvic acid, polymaleic acid and soluble iron salt; wherein the n-alkanoic acid-modified carboxymethyl chitosan, fulvic acid and polymaleic acid all have good temperature stability, react quickly with hydrogen sulfide under high temperature conditions, thereby realizing efficient desulfurization, and can still perform rapid desulfurization and regeneration reactions at 60°C, and can meet the needs of most high-temperature desulfurization in production. For example, when the desulfurization reaction is performed at a temperature above 60°C, the use days of the desulfurizer can be reduced or the use amount can be increased for adjustment.

To provide a polylactic acid resin composition which is excellent in heat resistance and flexibility.SOLUTION: A resin composition contains a polylactic acid-based resin, a polyhydroxyalkanoic acid-based resin and a plasticizer, wherein a ratio of the polyhydroxyalkanoic acid-based resin is 50 pts.mass or less with respect to 100 pts.mass of the polylactic acid-based resin. The polyhydroxyalkanoic acid-based resin may contain a hydroxy C4-10 alkanoic acid component (especially, hydroxy C4-6 alkanoic acid component) as a polymerization component. The polyhydroxyalkanoic acid-based resin may contain at least one selected from the group consisting of (R)-3-hydroxybutyric acid component and (R)-3-hydroxyvaleric acid component as a polymerization component. The plasticizer may be an ester-based plasticizer. A ratio of the plasticizer may be 1 to 50 pts.mass with respect to 100 pts.mass of the polylactic acid-based resin. A melt flow rate of the resin composition may be 3 to 40 g / 10 min.SELECTED DRAWING: None

The invention relates to a cosmetic or dermatological preparation comprising a) one or more alkylamidothiazoles, and b) one or more substances selected from the group consisting of: ba) C5-C25-triglycerides, bb) isopropyl esters of branched or linear C14-C26 alkanoic acids, bc) esters of branched C6-C16 alkanols with branched or linear C14-C26 alkanoic acids, c) and / or any mixture of them, d) in a cosmetic or dermatological formulation containing no more than 10% by weight of water, preferably no more than 5% by weight of water, in particular preferably no more than 1% by weight of water, ideally completely water-free.

The invention provides a triazinyl high-temperature CO2 corrosion inhibitor and a preparation method thereof, and belongs to the technical field of corrosion inhibition compositions and corrosion inhibitors. The triazinyl high-temperature CO2 corrosion inhibitor comprises the following components in percentage by weight: 10%-50% of s-triazine derivatives, 3%-16% of C2-C4 alkynol, 4%-10% of C12-C18 alkanoic acid, 0%-15% of a surfactant, 20%-40% of an organic solvent and 0%-40% of water, and the total percentage is 100%. The triazinyl high-temperature CO2 corrosion inhibitor is suitable for resisting CO2 corrosion at the high temperature of 60-120 DEG C, and the s-triazine derivative has a structure as shown in a formula (I): # imgabs0 # formula (1).

The invention discloses a preparation method and application of a 1, 2, 4-oxadiazole compound containing a camphor alkanoic acid group, and the structural formula of the 1, 2, 4-oxadiazole compound containing the camphor alkanoic acid group is shown in the specification. According to the application of the camphor alkanoic acid group-containing 1, 2, 4-oxadiazole compound in prevention and treatment of agricultural meloidogyne incognita, the activity result shows that the compound provided by the invention has a relatively good prevention and treatment effect on the meloidogyne incognita and sclerotinia rot of colza.

The present application relates to the technical field of paint, and disclose a kind of preparation method of waterproof weatherable water-based paint for road, 100 parts by weight water-based epoxy resin, 2-5 parts by weight 2,4-diamino alkanoic acid-6-(2,4-dihydroxyphenyl)-1,3,5-triazine, 1-5 parts by weight modified silicon dioxide etc. are mixed, to obtain waterproof weatherable water-based paint for road.Epoxy resin coating in thermal curing process, the carboxyl group of 2,4-diamino alkanoic acid-6-(2,4-dihydroxyphenyl)-1,3,5-triazine can participate in the curing reaction of epoxy resin, play good toughening effect, reduce water absorption, improve the ultraviolet resistance and weatherability.Nano-silica is modified, and the dispersibility and compatibility in coating are better, can play better reinforcing and toughening effect, and be conducive to improving the impact strength and bending strength of coating.

Provided is a method for the preparation of a composition comprising dissolved [18F]fluoride ions which is suitable for radiofluorination, said method comprising the steps of: providing an aqueous solution comprising water and [18F]fluoride ions; passing the aqueous solution through a solid phase extraction device comprising an anion exchange resin in order to trap [18F]fluoride ions on the anion exchange resin and to separate the [18F]fluoride ions trapped on the anion exchange resin from water; eluting [18F]fluoride ions from the anion exchange resin by passing an elution composition comprising an organic solvent and a salt of an alkanoic acid through the solid phase extraction device; obtaining a composition as an eluate which comprises the organic solvent, the salt of the alkanoic acid, and dissolved [18F]fluoride ions. Moreover, provided are the composition comprising dissolved [18F]fluoride ions, and a method for the preparation of a radiofluorinated organic compound, which involves the preparation of the composition comprising dissolved [18F]fluoride ions.

The invention discloses a long-chain ethylenediamine bis-n-alkanoic acid diammonium salt single-crystal phase change material and a preparation method thereof, ethylenediamine is used as an alkaline ligand, long-chain n-alkanoic acid is used as an acidic ligand, and the long-chain n-alkanoic acid is introduced to amino groups at two ends of ethylenediamine through a salt forming reaction to form the long-chain single-crystal phase change material with a sandwich layered structure. The structural formula of the material is [NH3 (CH2) 2NH3] < 2 + >. 2 [RCOO] <->, wherein R represents C11-C15 linear alkyl; the single crystal is regular in structure and belongs to a triclinic system and a P1 space group, and Z is equal to 1. The narrow phase change temperature zone and the phase change enthalpy of the material are averagely improved by more than 30% and can be maximally improved by more than 80% compared with corresponding long-chain n-alkanoic acid, and the material has good thermodynamic properties and is expected to be applied to the fields of industrial waste heat recovery, solar heat storage, aerospace thermal control systems and the like as an efficient phase change energy storage material.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

Cosmetic or dermatological preparations containing a) one or more alkylamidothiazoles and b) one or more substances selected from the group of ba) C 5 - C 25 - Triglyceride bb) the isopropyl ester of the branched or unbranched C 14 - C 26 -alkanoic acids bc) the esters of the branched C 6 - C 16 -alkanols and the branched or unbranched C 14 - C 26 -alkanoic acids c) and / or any mixtures thereof d) in cosmetic or dermatological preparations which contain not more than 10% by weight of water, preferably not more than 5% by weight of water, particularly preferably not more than 1% by weight and ideally are completely anhydrous.

An enzymatic method and system for producing a bioplastic polymer from a used product containing a thermoplastic polymer is disclosed. The thermoplastic polymer-containing product after use can be pyrolyzed to obtain a combined liquor of depolymerized alkanes. The combined liquid of alkanes may be contacted in vitro with an enzyme or a mixture of enzymes to produce a bioplastic polymer.

The present invention relates to a method for producing higher alkanones, preferably 6-undecanone, from ethanol and / or acetate, the method comprising (a) contacting ethanol and / or acetate with at least one microorganism capable of carbon chain extension to produce hexanoic acid and / or its esters from ethanol and / or acetate; (b) extracting the hexanoic acid and / or its esters from (a) using at least one extractant in an aqueous medium, wherein the extractant comprises at least one alkylphosphine oxide and at least one alkane comprising at least 12 carbon atoms; or at least one trialkylamine and at least one alkane comprising at least 12 carbon atoms; and (c) contacting the extracted hexanoic acid and / or its esters from (b) with at least one ketonization catalyst and optionally other alkanoic acids comprising 1 to 22 carbon atoms under suitable reaction conditions to chemically ketonize the hexanoic acid and optionally other alkanoic acids to higher alkanones, preferably 6-undecanone.

This aliphatic polyester film contains at least a polyhydroxy alkanoic acid and has a property such that the half width Hh of a height distribution histogram as determined by AFM measurement of a film cross section obtained with a rotary microtome is 5 nm to 60 nm inclusive. Provided is an aliphatic polyester film of which the disintegration start timing during biodegradation is shortened, thereby enhancing the treatment efficiency of composting at home (hereinafter, referred to as "home composting"), and which can also be suppressed from undergoing deterioration in quality, such as formation of wrinkles, when processed into a packaging material or a material for agricultural, forestry and fishery uses.

The purpose of the present invention is to provide: a resin composition which exhibits excellent biodegradability, moldability and mechanical properties at room temperature; and a molded article thereof.　Provided is a resin composition which contain: an aliphatic polyester-based resin (A) that contains repeating constituent units derived from an aliphatic diol and repeating constituent units derived from an aliphatic dicarboxylic acid having 9-36 carbon atoms as repeating constituent units derived from an aliphatic dicarboxylic acid; and at least one type selected from the group consisting of a poly(hydroxy alkanoate) (B) containing repeating constituent units derived from a hydroxy alkanoic acid having four or more carbon atoms, and an inorganic filler (F). Also provided is a molded article of the resin composition.

Provided are a recombinant human interleukin-11 mutant, and a conjugate of the mutant conjugated to a chemical molecule and a use thereof. The recombinant human interleukin-11 mutant achieves soluble expression in an Escherichia coli expression system by means of an SUMO sequence tandem fusion method. The conjugate is obtained by the site-specific conjugation of the mutant to the chemical molecule at a mutant amino acid residue in position W147 by means of a covalent bond. The chemical molecule is at least one of polyethylene glycol, an alkanoic acid aliphatic chain, and a hydrophilic high-molecular polymer containing an alkanoic acid aliphatic chain. The conjugate retains the binding capacity to human interleukin-11 receptor A while demonstrating significantly reduced binding capacity to human IL-6 signal transducer receptor. The conjugate shows the ability to block the signaling between human IL-11 and IL-11 RA and between human IL-11 and GP130 either in vivo or in vitro and can be used for the treatment of associated diseases with tissue fibrosis as a clinical manifestation caused by elevated primary or secondary IL-11.

The present invention relates to a method of extracting an alkanoic acid and / or ester thereof from an aqueous medium, the method comprising:(a) contacting the alkanoic acid and / or ester thereof in the aqueous medium with at least one extracting medium for a time sufficient to extract the alkanoic acid and / or ester thereof from the aqueous medium into the extracting medium,(b) separating the extracting medium with the extracted alkanoic acid and / or ester thereof from the aqueous mediumwherein the extracting medium comprises:a mixture of at least one alkyl-phosphine oxide, preferably Trioctylphosphine oxide (TOPO), and at least one alkanewherein the alkane comprises at least 12 carbon atoms.

The application provides a method for preparing diglyceride oil by a solvent-free enzyme method, comprising the following steps: S1, mixing saturated fatty acid A and saturated fatty acid B to prepare a liquid eutectic mixture; S2, mixing the eutectic mixture, glycerol and lipase in a reaction system to perform esterification to obtain diglyceride; S3, separating the prepared diglyceride, and adding the saturated fatty acid A and / or the saturated fatty acid B into the reaction system again to form a liquid eutectic mixture again, and repeating step 2; wherein in S1, the saturated fatty acid A and the saturated fatty acid B are both selected from C10-C20 alkanoic acid, in S2, the mass ratio of the eutectic mixture to the glycerol is 1:(1-5), and the temperature of the esterification is 35-78 DEG C. The application solves the problem that high-melting-point saturated fatty acid is difficult to use in the prior art of preparing diglyceride oil by a solvent-free enzyme method.