23 results about "Alkanoic acid" patented technology

Provided are a recombinant human interleukin-11 mutant, and a conjugate of the mutant conjugated to a chemical molecule and a use thereof. The recombinant human interleukin-11 mutant achieves soluble expression in an Escherichia coli expression system by means of an SUMO sequence tandem fusion method. The conjugate is obtained by the site-specific conjugation of the mutant to the chemical molecule at a mutant amino acid residue in position W147 by means of a covalent bond. The chemical molecule is at least one of polyethylene glycol, an alkanoic acid aliphatic chain, and a hydrophilic high-molecular polymer containing an alkanoic acid aliphatic chain. The conjugate retains the binding capacity to human interleukin-11 receptor A while demonstrating significantly reduced binding capacity to human IL-6 signal transducer receptor. The conjugate shows the ability to block the signaling between human IL-11 and IL-11 RA and between human IL-11 and GP130 either in vivo or in vitro and can be used for the treatment of associated diseases with tissue fibrosis as a clinical manifestation caused by elevated primary or secondary IL-11.

The invention provides a method for preparing diglyceride oil by a solventless enzymatic method, which comprises the following steps: S1, mixing saturated fatty acid A and saturated fatty acid B to prepare a liquid eutectic mixture; s2, mixing the eutectic mixture, glycerol and lipase in a reaction system, and carrying out esterification reaction to obtain diglyceride; s3, separating the prepared diglyceride, adding the saturated fatty acid A and / or the saturated fatty acid B into the reaction system again to form a liquid eutectic mixture again, and repeating the step 2; wherein in the step S1, the saturated fatty acid A and the saturated fatty acid B are selected from C10-C20 alkanoic acid, in the step S2, the mass ratio of the eutectic mixture to the glycerol is 1: (1-5), and the temperature of the esterification reaction is 35-78 DEG C. The method solves the problem that the high-melting-point saturated fatty acid is difficult to utilize in the existing technology for preparing the diglyceride oil by the solvent-free enzymatic method.

Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic assembly may include a first die having a surface; a second die having a first surface, an opposing second surface, and side surfaces between the first surface and the second surface, wherein the first surface of the second die is electrically coupled to the surface of the first die, and wherein the side surfaces of the second die are scalloped. In some embodiments, side surfaces of the second die may include a protective coating material, where the protective coating material includes an alkyl silane, a fluoroalkyl silane, a thiol, a phosphonic acid, an alkanoic acid, a siloxane, a silazane, a polyolefin, or a fluorinated polymer. In some embodiments, a microelectronic assembly may further include a dielectric material around a plurality of second dies and the dielectric material does not have an interface seam.

This invention relates to the biotechnological production of ω-functionalized carboxylic acids and their esters. Microbial cells are provided for the production of at least one ω-functionalized carboxylic acid ester from at least one alkane, wherein the cells are genetically modified relative to wild-type cells to increase the expression of: (i) an enzyme E1 capable of converting the alkane to the corresponding 1-alkanol; (ii) an enzyme E2 capable of converting the 1-alkanol of (i) to the corresponding 1-alkanal; (iii) an enzyme E3 capable of converting the 1-alkanal of (ii) to the corresponding alkanoic acid; (iv) an enzyme E4 capable of converting the alkanoic acid of (iii) to the corresponding alkanoic acid ester; and (iv) an enzyme E5 capable of converting the alkanoic acid ester of (iv) to the corresponding ω-hydroxy-alkanoic acid ester, and wherein the cells do not contain an increase relative to wild-type cells of the expression of the following enzymes selected from the group consisting of: 20 -E 24 Genetic modification of expression of at least one of them: -E 20 Acyl-ACP thioesterase, -E 21 Acyl-CoA thioesterase, -E 22 Acyl-CoA:ACP transacylase, -E 23 Polyketide synthase, and -E 24 Hexanoic acid synthase.

There is provided a hair styling polymer comprising: from 70% to 95% by weight, based on dry polymer, of a vinyl alkanoate monomer having from 4 to 13 carbons; from 5% to 30% by weight, based on dry polymer, of a carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbons; from 0% to 5% by weight, based on dry polymer, of a polyethylenically unsaturated crosslinker; from 0% to 20% by weight, based on dry polymer, of a further monoethylenically unsaturated monomer wherein the further monoethylenically unsaturated monomer is different from the alkanoic acid vinyl ester monomer having from 4 to 13 carbon atoms and the carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms; wherein the hair styling polymer comprises lt based on dry polymer; 15% by weight of a monoethylenically unsaturated C4-6 dicarboxylic acid monomer; and wherein the hair styling polymer comprises at least two different alkanoic acid vinyl ester monomers having from 4 to 13 carbons.

Provided in the present invention is a poly(3-hydroxybutyrate) polymer derivative, having a structure as represented by formula (I), wherein A is phenyl or phenyl C1-C4 alkyl, optionally substituted with a substituent selected from hydroxyl, C1-C4 alkyl, and C2-C4 alkenyl, R is saturated C1-C4 alkyl or hydroxyl-substituted saturated C1-C4 alkyl, Z is a polymeric residue of a hydroxy C3-C10 alkanoic acid, x is an integer from 1 to 20, and y is an integer from 0 to 20. Compared with an unmodified 3-hydroxybutyrate polymer, the poly(3-hydroxybutyrate) polymer derivative provided by the present invention has a significantly improved aromatic odor while retaining excellent broad-spectrum antimicrobial / antiviral effects of a poly(3-hydroxybutyrate) polymer, can also degrade under natural conditions, and has no irritation to the skin.

The disclosure relates to synthetic wax compositions including at least one long- chain hydrocarbon residue having 4 to 40 carbon atoms, and at least one oligomeric residue containing 4 to 50 ester units such as adipate-co-terephthalate units, alkanoate units, glycolic acid units, and / or lactic acid units. The synthetic wax can include other functional groups such as pendant carboxylic groups to facilitate emulsification and / or metal complexation of the wax, and / or unsaturated carbon-carbon double bonds to facilitate curing or crosslinking of the wax. The synthetic wax can be used as a coating on a variety of substrates, for example paper substrates, to impart water and / or oil resistance to the substrate. The presence of the carboxylic groups and / or oligomeric ester residue in the wax permits chemical degradation under very mild conditions, which in turn facilitates removal, repulping, and / or recycling of the synthetic wax.

The invention relates to a cosmetic or dermatological preparation comprising a) one or more alkylamidothiazoles, and b) one or more substances selected from the group consisting of: ba) C5-C25-triglycerides, bb) isopropyl esters of branched or linear C14-C26 alkanoic acids, bc) esters of branched C6-C16 alkanols with branched or linear C14-C26 alkanoic acids, c) and / or any mixture of them, d) in a cosmetic or dermatological formulation containing no more than 10% by weight of water, preferably no more than 5% by weight of water, in particular preferably no more than 1% by weight of water, ideally completely water-free.

The invention discloses a preparation method and application of a 1, 2, 4-oxadiazole compound containing a camphor alkanoic acid group, and the structural formula of the 1, 2, 4-oxadiazole compound containing the camphor alkanoic acid group is shown in the specification. According to the application of the camphor alkanoic acid group-containing 1, 2, 4-oxadiazole compound in prevention and treatment of agricultural meloidogyne incognita, the activity result shows that the compound provided by the invention has a relatively good prevention and treatment effect on the meloidogyne incognita and sclerotinia rot of colza.

The present application relates to the technical field of paint, and disclose a kind of preparation method of waterproof weatherable water-based paint for road, 100 parts by weight water-based epoxy resin, 2-5 parts by weight 2,4-diamino alkanoic acid-6-(2,4-dihydroxyphenyl)-1,3,5-triazine, 1-5 parts by weight modified silicon dioxide etc. are mixed, to obtain waterproof weatherable water-based paint for road.Epoxy resin coating in thermal curing process, the carboxyl group of 2,4-diamino alkanoic acid-6-(2,4-dihydroxyphenyl)-1,3,5-triazine can participate in the curing reaction of epoxy resin, play good toughening effect, reduce water absorption, improve the ultraviolet resistance and weatherability.Nano-silica is modified, and the dispersibility and compatibility in coating are better, can play better reinforcing and toughening effect, and be conducive to improving the impact strength and bending strength of coating.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

This aliphatic polyester film contains at least a polyhydroxy alkanoic acid and has a property such that the half width Hh of a height distribution histogram as determined by AFM measurement of a film cross section obtained with a rotary microtome is 5 nm to 60 nm inclusive. Provided is an aliphatic polyester film of which the disintegration start timing during biodegradation is shortened, thereby enhancing the treatment efficiency of composting at home (hereinafter, referred to as "home composting"), and which can also be suppressed from undergoing deterioration in quality, such as formation of wrinkles, when processed into a packaging material or a material for agricultural, forestry and fishery uses.

Provided are a recombinant human interleukin-11 mutant, and a conjugate of the mutant conjugated to a chemical molecule and a use thereof. The recombinant human interleukin-11 mutant achieves soluble expression in an Escherichia coli expression system by means of an SUMO sequence tandem fusion method. The conjugate is obtained by the site-specific conjugation of the mutant to the chemical molecule at a mutant amino acid residue in position W147 by means of a covalent bond. The chemical molecule is at least one of polyethylene glycol, an alkanoic acid aliphatic chain, and a hydrophilic high-molecular polymer containing an alkanoic acid aliphatic chain. The conjugate retains the binding capacity to human interleukin-11 receptor A while demonstrating significantly reduced binding capacity to human IL-6 signal transducer receptor. The conjugate shows the ability to block the signaling between human IL-11 and IL-11 RA and between human IL-11 and GP130 either in vivo or in vitro and can be used for the treatment of associated diseases with tissue fibrosis as a clinical manifestation caused by elevated primary or secondary IL-11.

The application provides a method for preparing diglyceride oil by a solvent-free enzyme method, comprising the following steps: S1, mixing saturated fatty acid A and saturated fatty acid B to prepare a liquid eutectic mixture; S2, mixing the eutectic mixture, glycerol and lipase in a reaction system to perform esterification to obtain diglyceride; S3, separating the prepared diglyceride, and adding the saturated fatty acid A and / or the saturated fatty acid B into the reaction system again to form a liquid eutectic mixture again, and repeating step 2; wherein in S1, the saturated fatty acid A and the saturated fatty acid B are both selected from C10-C20 alkanoic acid, in S2, the mass ratio of the eutectic mixture to the glycerol is 1:(1-5), and the temperature of the esterification is 35-78 DEG C. The application solves the problem that high-melting-point saturated fatty acid is difficult to use in the prior art of preparing diglyceride oil by a solvent-free enzyme method.

This invention discloses a comprehensive recycling method for byproducts of alkyl dichlorophosphine production. The method includes: reacting an alkanoic acid compound with the alkyl dichlorophosphine in the byproduct to generate a phosphorus-containing flame retardant or its intermediate, obtaining a post-reaction mixture; then, gradually separating sodium chloride and precipitates in the form of hydrated aluminum trichloride by progressively increasing the hydrogen chloride content in the system, obtaining a mixture containing the phosphorus-containing flame retardant or its intermediate, a small amount of aluminum chloride, sodium chloride, and hydrochloric acid; distilling and concentrating the mixture, adding sodium hydroxide, filtering, acidifying and concentrating the filtrate, and then extracting and purifying. This method yields pure sodium chloride, pure hydrated aluminum chloride, and the phosphorus-containing flame retardant or its intermediate. The steps are clear, the function is well-defined, and the method is simple and easy to control, completely solving the problem of comprehensive utilization of complex salts in the production of methyl dichlorophosphine.

There is provided a hair styling polymer comprising: a cosmetically acceptable carrier; and a hair styling polymer comprising: 70% to 95% by weight, based on the dry polymer, of a monoethylenically unsaturated vinyl alkanoate monomer having 4 to 13 carbon atoms; from 5% to 30% by weight, based on the dry weight of the hairstyling polymer, of structural units of a monoethylenically unsaturated carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms; from 0% to 5% by weight, based on the dry weight of the hair styling polymer, of structural units of a polyethylenically unsaturated crosslinking monomer; and 0% to 20% by weight, based on the dry weight of the hairstyling polymer, of structural units of other monoethylenically unsaturated monomers, wherein the further monoethylenically unsaturated monomer is different from the monoethylenically unsaturated alkanoic acid vinyl ester monomer having from 4 to 13 carbon atoms and the monoethylenically unsaturated carboxylic acid / carboxylic acid anhydride functionalized vinyl ester monomer having from 4 to 12 carbon atoms.

The invention relates to an electrolyte comprising alkyl alkanoates, ketones and / or nitriles as main organic solvents for batteries for recycling lithium ions. A lithium ion circulating battery includes an electrolyte including an organic solvent and a lithium salt in the organic solvent. The organic solvent comprises greater than or equal to 70% by weight of a primary solvent comprising alkyl alkanoates, ketones, nitriles, or a combination thereof. The electrolyte is advantageously useful in a battery comprising a positive electrode comprising an electroactive material comprising a layered nickel-rich lithium transition metal oxide.

The present invention mainly relates to a process for the production of omega-aminoalkanoic acids of formula NH2-(CH2)n-COOH n by reacting the corresponding omega-bromoalkanoic acids with ammonia, wherein n is an integer from 9 to 11, which process comprises the following steps: i) reacting said omega-bromoalkanoic acids with an excess of aqueous ammonia solution, and ii) isolating the omega-aminoalkanoic acids formed from the reaction mixture, characterized in that the aqueous ammonia solution has a concentration of 35 to 70 wt.-%, and in that phase i) is carried out at a pressure higher than atmospheric pressure, at a pressure of 0.11 to 2.0 MPa absolute.

Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

What claimed is a consumer preparation comprising or consisting of an antioxidant composition, wherein said antioxidant composition comprises or consists of (a) at least one primary antioxidant, which is a 2,5-dihydroxy alkanoic acid, a salt or an ester thereof according to formula (I): wherein R stands for hydrogen, a monovalent cation, a C1-C6 alkyl or an C2-C4 alkenyl group; and (.......) has the meaning of a single or double bond; and (b) a carrier on condition that said preparation is free of oxidative dyestuffs, and the preparation comprises the at least one 2,5-dihydroxy-alkanoic acid its salt or ester according to formula (I) in a working amount of from about 0.005 to about 0.2 wt.-percent – calculated on the preparation.

The application discloses a water-based polyisocyanate, a preparation method and application thereof, and a water-based polyisocyanate two-component system. Raw materials of the water-based polyisocyanate include polyisocyanate, butanone oxime, polyether polyol, small-molecule alicyclic polyol, monol, hydroxy alkanoic acid and alkaline neutralizer. The water-based polyisocyanate has high modulus and is closed, has good hydrophilicity, good water dispersion performance, can be dispersed or dissolved in water, has good stability and construction performance, and a resin film prepared by matching the water-based polyisocyanate with water-based polyurethane and hydroxyl acrylic emulsion has high modulus.

The invention relates to a microbial cell for producing at least one lipid having general formula II from at least one carbon substrate, in which R1 and R2 independently of each other comprise the same or different organic groups each having 5 to 13 carbon atoms, wherein the cell is a non-pathogenic cell genetically modified to increase the heterologous expression of the following enzymes relative to the wild-type cell: Enzyme E1, a 3-(3-hydroxyalkanoyloxy) alkanoic acid (HAA) synthase comprising SEQ ID NO: 1, SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 15 or a variant thereof wherein the variant comprises a 60% sequence identity to SEQ ID NO: 1, 7, 11 or 15; and-an enzyme E2 comprising a glycosyltransferase (EC 2.4) of SEQ ID NO: 2, SEQ ID NO: 8 or SEQ ID NO: 12 or a variant thereof wherein the variant comprises a 60% sequence identity to SEQ ID NO: 2, 8 or 12.

To provide a dental resin-reinforced glass ionomer cement composition which causes less stringiness of the mixed material than conventional techniques, is excellent in cavity filling property and in application property to a dental prosthesis device, becomes soon after completion of mixing in a state that it is possible to perform shaping operation, and exhibits excellent mixability, mechanical characteristic and transparency.To provide a dental resin-reinforced glass ionomer cement composition comprising(a) acid-reactive glass powder,(b) polyalkanoic acid,(c) water,(d) polymerizable monomer,(e) porous inorganic filler: 1% by mass or more and 15% by mass or less, and(f) polymerization initiator, whereinthe center portion of the (e) porous inorganic filler is an inorganic particle consisting of only silicon dioxide or consisting of silicon dioxide and an oxide containing one or more metal elements.