Plaster

A patch and pasting technology, which is applied in medical science, absorbent pads, sheet transportation, etc., can solve problems such as bad circulation, accompanied by pain, easy peeling, etc., to reduce skin irritation, improve follow-up, prevent peeling effect

Inactive Publication Date: 2003-07-16
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, even with the above-mentioned patch, if the adhesiveness of the adhesive layer is sufficiently reduced in order to prevent rashes, the skin adhesiveness becomes insufficient and it is easy to peel off. On the other hand, if sufficient adhesiveness is given Make it so that it will not peel off even if it is pasted on the part with large movements, it will easily cause skin rashes or it will be accompanied by pain when peeling off, and eventually a bad cycle will occur.
[0005] As mentioned above, the conventional patch has not fully satisfied the two contradictory characteristics of high peel resistance (not easy to peel off) and low skin irritation (suppresses skin rash and pain when peeled off) in a good balance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Put 70 parts by weight of distilled water, 3 parts by weight of gelatin, 2 parts by weight of polyvinyl alcohol, and 2 parts by weight of kaolin into the mixer, and mix at about 50° C. to obtain a uniform dispersion. Then, add the dispersion liquid of 13 parts by weight of glycerol prepared in advance, 5 parts by weight of sodium polyacrylate, 2 parts by weight of methyl vinyl ether maleic anhydride copolymer, and 1 part by weight of aluminum hydroxide to the above-mentioned dispersion liquid, stir and mix, Then, a solution obtained by dissolving 0.5 parts by weight of ketoprofen in 1.5 parts by weight of peppermint oil was added, stirred and mixed to obtain a uniform mixture.

[0051] Next, the resulting mixture was stretched on a polypropylene film (stiffness: 75 mm) so that the weight after drying became 140 cm 2 It is 10g, and then it is made of polyester woven cloth (fiber thickness: 75 denier, head payment: 120g / m 2 ) of the support body covering, crimping transf...

Embodiment 2

[0053] 31.92 parts by weight of distilled water, 3 parts by weight of gelatin, 3 parts by weight of polyvinylpyrrolidone, and 3 parts by weight of zinc oxide were charged into the mixer, and mixed at about 50° C. to obtain a uniform dispersion. Then, in the above dispersion liquid, add the dispersion liquid of 50 weight parts of polyethylene glycol, 4 weight parts of sodium polyacrylate, 3 weight parts of polyacrylic acid and 0.08 weight part of polyethylene glycol diglycidyl ether prepared in advance, stir and mix , Then add the solution obtained by dissolving 0.5 parts by weight of suprofen in 1.5 parts by weight of benzyl alcohol, stir and mix to obtain a uniform mixture.

[0054] Next, the obtained mixture was stretched on a polyethylene film (stiffness: 130mm) so that the weight after drying became 140cm 2 It is 5g, and then it is woven with polypropylene (fiber thickness: 35 denier, eye payment: 110g / m 2 ) covered, crimped, transferred, cut, and made into a cataplasm of...

Embodiment 3

[0056] Disperse 4 parts by weight of synthetic aluminum silicate in 78.4 parts by weight of distilled water, add 1 part by weight of gelatin, 0.05 parts by weight of sorbitol polyglycidyl ether, 0.2 parts by weight of water-soluble placenta extract, and 0.1 parts by weight of allantoin Mix with 0.25 parts by weight of methyl p-hydroxybenzoate, add 6 parts by weight of sodium polyacrylate and 10 parts by weight of polyethylene glycol, and stir to obtain a uniform mixture.

[0057] Next, the obtained mixture was stretched on a polyester film (stiffness: 120mm) so that the weight after drying became 140cm 2 It is 10g, and then it is made of polyester woven cloth (fiber thickness: 60 denier, head payment: 110g / m 2 ) covered, crimped and transferred, cut to make a sheet-like cataplasm with a vertical length of 10 cm, a horizontal width of 14 cm, and a thickness of 2.00 mm to obtain the desired patch.

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Abstract

A plaster having a support comprising a synthetic fiber fabric and an adhesive layer laminated on the fabric, characterized in that it has a bending resistance of 10 to 30 mm and a probe tack value of 0.25 to 1.2 N. The plaster allows satisfactory prevention of the exfoliation thereof in being pasted and also satisfactory suppression of a rash and a pain in being peeled.

Description

technical field [0001] The present invention relates to a patch preparation, and more specifically, to a patch preparation capable of sufficiently preventing peeling and suppressing skin rashes and pain during peeling when applied to plasters, cataplasms, and the like. Background technique [0002] Conventionally, a large number of medical patches such as transdermal absorbents and adhesive plasters in which a drug-containing adhesive layer is laminated on a support have been manufactured. For this kind of patch, it is required to have the following characteristics: even if it is applied to the joints or the face where the movement is large and the skin is stretched rapidly, it will not peel off, and even if it is applied for a long time, there will be no skin rash or rash. red. Among conventional patches, those that were not easy to peel off were prone to skin rashes or redness, and were accompanied by pain when peeled off, while those that were less irritating to the skin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61K9/70A61L15/58
CPCA61K9/7061A61K9/7053A61L15/58A61K9/70
Inventor 太田重雄鹤田清美
Owner HISAMITSU PHARM CO INC
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