790 results about "Urine production" patented technology

The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients. The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample. Yet another aspect of the invention is an automated system for processing a fluid sample that includes: at least one filtration chamber that includes a microfabricated filter; automated means for directing fluid flow through at least one filtration chamber of the automated system, and means for collecting enriched rare cells. The present invention also includes methods of using automated systems for separating rare cells from fluid samples. Preferred fluid samples are blood, effusion, or urine samples, and rare cells that can be enriched from such sample include nucleated red blood cells and cancer cells.

A battery pack for self-diagnosis and a system using the same, which can read a data value from a body fluid sensor (referred to as a biosensor) reacting with body fluid such as urine, and indicate a measurement value of a test item such as a blood glucose level, a cholesterol level or etc. The battery pack includes: a power supply for supplying electric power to a working electrode of the body fluid sensor; a current detector for detecting the amount of electric current flowing into the working electrode; a battery pack controller for controlling an electric power supply operation for the working electrode, reading, from a memory, the test item-based measurement value corresponding to the detected current amount, and outputting the read measurement value; and an interface for carrying out an interface function so that the test item-based measurement value outputted from the battery pack controller can be sent to the main body of the mobile communication terminal.

A cartridge is provided for receiving a sample, including but not limited to blood, urine, and the like. The cartridge includes an input port or dock for receiving a sample from a sample container. A first chamber is in fluid communication with the input port. A flow cell is in fluid communication with the first chamber. The flow cell contains at least one reagent. The reagent can be a calibrant, a fluid containing reactant, a fluid not containing a reactant, a sample, and the like. A pressure port is configured to be coupled to a pressure source, including but not limited to a syringe pump, and the like. A vent port is also provided. The cartridge is configured to maintain fluids in a sealed manner.

Methods, systems, and computer program products for obtaining a sample in vivo and/or treating a subject include positioning an elongated transurethral catheter in the prostatic urethra of a subject, the catheter having a bladder anchoring balloon, at least one biosample entry port disposed axially away from the bladder anchoring balloon, and an axially extending biosample flow channel in fluid communication with the biosample entry port held internally in the catheter. The anchoring balloon is inflated to position the catheter so that the fluid entry port is proximate the prostatic urethra of the subject and prostatic fluid is suctioned from the prostatic urethra into the biosample entry port and into the biosample flow channel. The catheter can include a thermal treatment balloon and/or dilatation balloon and the suctioned sample can be obtained concurrently with, during, or proximate in time to the applied treatment. The catheter can be configured to allow urine to drain therethrough during the treatment/collection of the sample while keeping the urine isolated from the collected prostatic fluid sample.

This invention relates to assays for an analyte in a liquid sample such as a body fluid. More particularly, the invention relates to a method and apparatus for the detection of a ligand in a body fluid such as urine or blood, which includes an immobilization zone for interfering agents in a sample.

The present invention provides methods for the large-scale production of recombinant butyrylcholinesterase fused to human serum albumin in cell culture, and in the milk and/or urine of transgenic mammals. The recombinant butyrylcholinesterase-albumin fusion protein of this invention can be used to treat and/or prevent organophosphate pesticide poisoning, nerve gas poisoning, cocaine intoxication, and succinylcholine-induced apnea.

Multi-functional urine collection devices, embodiments of which can include a self-expanding container having a receptacle for receiving urine from the tubing, a pump for moving urine through the tubing and into a receptacle, extendable tubing that may be shortened and/or lengthened, and/or one or more meters for monitoring, measuring, transmitting or storing a characteristic from the urine.

This invention is directed to an absorbent article, preferably a diaper or training pants, having a backsheet, an absorbent core and a topsheet, provided with at least one opening adapted to receive fecal material, comprising also a genital coversheet, which in use covers the genitals, and which is positioned in, under or above part of the opening, such that a void space can be created between the genital coversheet and the absorbent core and such that a void space is present between the topsheet and the absorbent core.

MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.

A disposable absorbent article including a wetness sensation member and visible highlighting indicating the presence of the wetness sensation member to facilitate an opportunity for the toilet training of the wearer. The wetness sensation member includes a permeable layer and a flow control layer. Urine deposited on the wetness sensation member can penetrate through the permeable body-facing layer in a z direction away from the wearer to the flow control layer. The flow control layer retards the passage of the urine through the wetness sensation member in the z direction while supporting the movement of the urine in an x-y plane to increase the wetted area contacting the wearer's skin and thereby enhance the wearer's awareness that urination has occurred. The visible highlighting is visible when viewing a body-facing surface of the article and may be associatively correlated with an externally visible marking and/or with the concept of toilet training.

The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.

An apparatus for monitoring the intra-abdominal pressure of a hospitalized patient includes a urinary catheter connected to a urine valve providing selectable communication between a discharge end of the urinary catheter and either a drain or a fluid source. Preferably, the urine valve is adapted for remote actuation and has a housing adapted to resist patient discomfort from leg-valve contact. Plumbing structure desirably maintains fluid supply and drain conduits in a substantially parallel arrangement to assist routing those conduits between a patient's legs. When the urine valve is oriented to permit communication with the fluid source, an infusion pump may be used to infuse a known quantity of fluid through the urine valve and into the patient's bladder. A pressure transducer desirably is connected in-circuit to indicate the fluid's pressure. To facilitate the infusion process, an automatic flow control device may be included in a fluid supply path and arranged to permit repetitive operation of a syringe to inject a bolus of fluid into the patient's bladder. Subsequent to a period of time in which to make a pressure measurement, preferred embodiments of the urine valve automatically return to a bladder draining position.

The present invention provides a water absorbing agent which maintains excellent water absorbing properties for a long time, even when urine composition of human urine varies depending. A particulate water absorbing agent comprising a water-absorbing resin obtained by crosslinking polymerization of an unsaturated monomer, which exhibits Centrifuge retention capacity in a physiological saline solution of not lower than 32 g/g, mass median particle size (D50) of 200 to 400 μm, ratio of particles with diameter of smaller than 150 μm of 0 to 2% by weight, and increased extractables by deterioration of 0 to 15% by weight and extractables for one hour in deterioration test liquid of 0.1 to 30% by weight.

PCT No. PCT/SE96/00607 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed May 9, 1996 PCT Pub. No. WO96/35395 PCT Pub. Date Nov. 14, 1996A device for maintaining a passage through the prostate gland (13) after treatment of a catheter (10) inserted through the urethra into the prostate gland, the catheter (10) being provided with means (11) for heating the prostate gland. A sleeve (12) is received over the catheter (10) so as to follow the catheter (10) during insertion into a desired position within the prostate gland, and the sleeve (12) is formed to remain in the desired position when the catheter is removed from the prostate gland, thereby maintaining a passage having a predetermined lower inner diameter through the prostate gland when tissue in the prostate gland swells.

Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.

An improved apparatus for monitoring the intra-abdominal pressure of a hospitalized patient includes a urinary catheter connected to a urine valve having selectable communication positions between a discharge end of the urinary catheter and either a drain or a fluid source. Preferably, the urine valve has a housing adapted to resist patient discomfort from leg-valve contact. One operable protective housing may be embodied as a separate tray component. Plumbing structure desirably maintains fluid supply and drain conduits in a substantially parallel arrangement to assist routing those conduits between a patient's legs. When the urine valve is oriented for communication to the fluid source, an infusion pump may be used to introduce a known quantity of fluid through the urine valve and into the patient's bladder where the fluid's pressure can be measured. Desirably, a double check valve is included in a fluid supply path and arranged to permit repetitive operation of a syringe to inject a bolus of fluid into the patient's bladder. Subsequent to making a pressure measurement, the urine valve is returned to the bladder draining position.

The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as preeclampsia, in the first, second, and/or third trimester of pregnancy. The present invention also provides kits for identifying and screening patients at risk of developing a complication of pregnancy, such as preeclampsia.

A device for collecting, testing and storing fluids includes a container and a removable cap. Body fluids, such as urine, are collected in the container. The cap defines a test strip holder that receives one or more drug test strips and an adulteration strip. An opening defined through a bottom of the cap provides fluid communication between the container and the cap. When tilted, fluid from the container enters the cap through the hole. A variety of plugs may be employed to block the opening and thereby prevent fluid communication between the container and the cap after fluid has entered the cap. The remaining uncontaminated and untested body fluid is stored in the container and thus made available for further confirmation testing. Associated methods for collecting, testing and storing fluids with a single device are also provided. A method of manufacturing the foregoing test device is also provided.

Here is disclosed a urine receiver. The urine receiver comprises a container member adapted to suck urine discharged from a wearer of the urine receiver and a urine sensor provided with a pair of electrodes interposed between the container member and the wearer's skin and serving to detect the urine. The paired electrodes covered with insulating coating. The coating is formed with through-holes adapted to expose a limited area of the electrodes.

A flexible bag wrap is adapted for use in an incontinence management system. The bag wrap includes a flexible base adapted for wrapping around a body part of a user. The base includes a three-dimensional fabric spacer. The fabric spacer has an inside facing for residing nearest the skin of the user, an outside facing opposite the inside facing, and an intermediate spacer yarn interconnecting the inside and outside facings. A collection bag is carried by the base adjacent the outside facing of the fabric spacer, and is adapted for collecting urine excreted by the user.

Methods of assessing the ongoing kidney status in a subject afflicted with chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in fluid samples over time is disclosed. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine and serum as a result of chronic renal tubule cell injury. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.