Application of Phyllanthoid A in preparing medicament for treating rheumatoid arthritis

A technology for arthritis and rheumatoid arthritis, applied in the field of Phyllanthoid A in the preparation of drugs for the treatment of rheumatoid arthritis, can solve the problems of poor action selectivity, ulcers, and easy induction of infection, and achieve outstanding substantive characteristics and strong inhibitory activity Effect

Inactive Publication Date: 2013-12-25
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of Phyllanthoid A in preparing medicament for treating rheumatoid arthritis
  • Application of Phyllanthoid A in preparing medicament for treating rheumatoid arthritis
  • Application of Phyllanthoid A in preparing medicament for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Phyllanthoid A tablet involved in the present invention:

[0013] Take 5 grams of compound Phyllanthoid A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Phyllanthoid A capsules involved in the present invention:

[0015] Take 5 grams of compound Phyllanthoid A, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Phyllanthoid A of the present invention on rat adjuvant arthritis

[0018] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind foot of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Phyllanthoid A 5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given diclofenac 10 mg / kg, the control group was given equal volume of distilled water, once a day, for 7 consecutive d...

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PUM

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Abstract

The invention provides Phyllanthoid A for treating immune inflammation, which is a medicament for treating rheumatoid arthritis. By adopting terfenatine and diclofenac sodium as controls, Phyllanthoid A has an exact curative effect, and is disclosed for the first time. The frame model is a brand-new frame model, and Phyllanthoid A has a strong activity in treating rheumatoid arthritis, has a highlighted substantial characteristic, and is remarkably progressed when being used for preventing and treating rheumatoid arthritis.

Description

technical field [0001] The present invention relates to a new application of compound Phyllanthoid A, in particular to the application of Phyllanthoid A in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The compound Phyllanthoid A involved in the present invention is a new compound published in 2013 (Jian-Qia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P19/02A61P29/00
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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