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Rheumatoid-arthritis-related single-gene single nucleotide polymorphism site and application thereof

A single nucleotide polymorphism and polymorphism technology, applied in the field of biomedicine, can solve problems such as increasing the risk of rheumatoid arthritis

Inactive Publication Date: 2015-05-20
TSINGHUA UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the past studies, people have found a variety of susceptibility genes related to the pathogenesis of rheumatoid arthritis, the more important ones are the DR region of human leukocyte antigen (HLA) and the tumor necrosis factor alpha (TNF-α) gene, etc. Certain single nucleotide polymorphisms in these genes significantly increase the risk of rheumatoid arthritis

Method used

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  • Rheumatoid-arthritis-related single-gene single nucleotide polymorphism site and application thereof
  • Rheumatoid-arthritis-related single-gene single nucleotide polymorphism site and application thereof
  • Rheumatoid-arthritis-related single-gene single nucleotide polymorphism site and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Example 1. rs1050501 is a single nucleotide polymorphism associated with rheumatoid arthritis

[0040] 1. Selection criteria for rheumatoid arthritis case group and control group

[0041] Selection criteria for the rheumatoid arthritis case group: 404 patients with rheumatoid arthritis, all of whom were from mainland China and were not related by blood. All patients met the RA classification standard established by the American College of Rheumatology (ACR) in 1987 (Arthritis & Rheumatism, 1988; 31(3):315-24).

[0042] Selection criteria for the rheumatoid arthritis control group: normal healthy people with no history of rheumatoid arthritis or other autoimmune diseases (the age and gender are matched with the case group), and all the control groups are from mainland China.

[0043] The rheumatoid arthritis case group included 404 patients with rheumatoid arthritis, and the control group included 778 normal healthy people. The number and average age of the different sexes in t...

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Abstract

The invention discloses a rheumatoid-arthritis-related single-gene single nucleotide polymorphism site and an application thereof. According to the technical scheme disclosed by the invention, the application is an application of substances for detecting polymorphism or genotype of rs1050501 in human genome in preparation of products for screening patients with rheumatoid arthritis, and an application of substances for detecting polymorphism or genotype of rs1050501 in human genome in preparation of products for predicting the illness states of the patients with rheumatoid arthritis. The substances for detecting the polymorphism or genotype of rs1050501 can be combined with other substances (such as other substances for detecting leprosy-related single nucleotide polymorphism or genotype) to prepare the products for screening patients with leprosy or predicting the illness states of the patients with rheumatoid arthritis.

Description

Technical field [0001] The invention relates to a single gene single nucleotide polymorphism site related to rheumatoid arthritis in the field of biomedicine and its application. Background technique [0002] Rheumatoid arthritis is a chronic systemic inflammatory disease whose etiology has not been determined. The main clinical manifestations are polysynovial arthritis and extra-articular lesions. It is an autoimmune inflammatory disease and is related to the environment, cells, viruses, genetics, and sex hormones. It is closely related to factors such as neuropsychiatric status. If it is not treated in time, it will easily cause irreversible joint deformities and rigidity, resulting in a higher disability rate. Rheumatoid arthritis has become one of the main health problems of worldwide concern, with an incidence rate of 0.5%-1% worldwide, and an incidence rate of 0.4% in my country. [0003] The pathogenesis of rheumatoid arthritis is not yet clear. A large number of studies ha...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/156
Inventor 刘万里孙晓麟徐利玲栗占国沈志勋
Owner TSINGHUA UNIV
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