Application of Aphanamixoid A in medicine for treating rheumatoid arthritis

An arthritis and rheumatoid technology, applied in the application field of Aphanamixoid A in the treatment of rheumatoid arthritis drugs, can solve the problems of poor action selectivity, ulcers, damage to the gastrointestinal mucosa, etc., to achieve outstanding substantive characteristics and inhibitory activity strong effect

Inactive Publication Date: 2013-05-29
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of Aphanamixoid A in medicine for treating rheumatoid arthritis
  • Application of Aphanamixoid A in medicine for treating rheumatoid arthritis
  • Application of Aphanamixoid A in medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of compound Aphanamixoid A tablet involved in the present invention:

[0012] Take 20 grams of compound Aphanamixoid A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Aphanamixoid A capsules involved in the present invention:

[0014] Get 20 grams of compound Aphanamixoid A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1, the influence of Aphanamixoid A of the present invention on rat adjuvant arthritis

[0017] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind foot of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally given Aphanamixoid A 5.0, 10.0, 20.0 mg / kg of the present invention, and the positive control group was orally given diclofenac 10 mg / kg, the control group was given equal volume of distilled water, once a day, for 7 consecutive d...

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PUM

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Abstract

The invention discloses Aphanamixoid A for treating immunity inflammation, and particularly relates to Aphanamixoid A for preparing a medicine for treating rheumatoid arthritis. The rheumatoid arthritis is definite in curative effect by taking terfenadine and diclofenac sodium as references. The application of the Aphanamixoid A in preparation of the medicine for treating the rheumatoid arthritis is firstly disclosed because a skeleton type belongs to a fire-new skeleton type and the inhibitory activity of the Aphanamixoid A on the rheumatoid arthritis is inconceivably high; and the Aphanamixoid A has outstanding substantiality characteristic without possibility of any inspiration given by other compounds and obviously achieves the outstanding progress by being used for preventing and treating the rheumatoid arthritis.

Description

technical field [0001] The invention relates to the application of Aphanamixoid A in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The compound Aphanamixoid A involved in the present invention was published in 2012 (Cai, J. Y. et al., 2012. Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P19/02A61P29/00
Inventor 冯怡李丽丽龚霞吴俊华
Owner 吴俊华
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