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Application of physically-modified cobra venom in preparation of medicament for treating pulmonary fibrosis

A cobra snake venom, physical modification technology, applied in the field of cobra snake venom, preparation of drugs for the treatment of lung inflammation and pulmonary fibrosis, can solve the problems that the effect of lung inflammation has not been reported yet, achieve good treatment of pulmonary fibrosis, reduce synthesis , the effect of large effective range

Inactive Publication Date: 2012-07-04
SUZHOU RENBEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

With the deepening of research, now snake venom and its products have been applied clinically. In addition to the analgesic effect, the study found that it has good curative effect on anti-rheumatism, anti-tumor and treatment of nervous system diseases, but it is not effective in treating lung diseases. Unreported role in inflammation and pulmonary fibrosis

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  • Application of physically-modified cobra venom in preparation of medicament for treating pulmonary fibrosis
  • Application of physically-modified cobra venom in preparation of medicament for treating pulmonary fibrosis
  • Application of physically-modified cobra venom in preparation of medicament for treating pulmonary fibrosis

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Embodiment Construction

[0033] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions adopted in the examples can be further adjusted according to the conditions of specific experiments, and the implementation conditions not indicated are usually the conditions in routine experiments.

[0034] The animal pharmacodynamic experiment of the Chinese cobra venom after embodiment physical modification

[0035] (1) Acute lung injury experiment induced by lipopolysaccharide in mice

[0036] Lipopolysaccharide (LPS) is a component in the cell wall of Gram-negative bacteria, which can cause various inflammatory reactions in the body. A single administration of 5 mg / kg LPS can make a mouse model of acute lung injury. Kunming mice were randomly divided into 5 groups (n=10) of half and half female, body w...

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Abstract

The invention discloses application of cobra venom in preparation of a medicament for treating lung inflammatory disease and pulmonary fibrosis. Animal experiment proves that Chinese cobra venom can alleviate acute endotoxin poisoning symptom within a range of 10-3000mug / kg, particularly has obvious therapeutic action on lung inflammatory disease caused by endotoxin, and can be used for alleviating inflammatory cell infiltration, alveolar septum thickening, and focal atelectasis and emphysema. Repeated small dose of endotoxin can result in pulmonary fibrosis, the cobra venom can significantly alleviate pulmonary fibrosis symptom and reduce alveoli damage and collagen hyperplasia. Naturally-modified Chinese cobra venom and physically-modified Chinese cobra venom have similar actions, but the physically-modified Chinese cobra venom has better action. Used for treating lung inflammatory disease, the Chinese cobra venom has the advantages of low dose, safety, capability of being orally administrated, injected, and administered through oral mucous membrane and skin and the like.

Description

technical field [0001] The invention relates to the technical field of new application of medicine, and specifically relates to the application of physically modified cobra snake venom in the preparation of medicines for treating pulmonary inflammation and pulmonary fibrosis. Background technique [0002] Snake venom is a complex mixture of components secreted by the snake's venom glands. Fresh venom is egg white-like viscous liquid with a special fishy smell. The venom of different snake species has different colors, and the venom of the Chinese cobra is light yellow. More than 90% of the dry matter of snake venom is protein, which is the main component of its toxicity and biological activity. The components of Chinese cobra venom mainly include cobra venom factor (1%-2%), cardiotoxin (40%-50%, also known as cytotoxin, membrane toxin), neurotoxin (10%) and other proteins. The traditional medicine of the motherland believes that cobra and its toxic components can clear th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/58A61P11/00A61K35/583
Inventor 秦正红崔奎
Owner SUZHOU RENBEN PHARMA
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