15results about How to "Delay progress" patented technology

This invention discloses the application of a reagent that inhibits ADNP gene expression or ADNP protein activity in the preparation of drugs for treating renal fibrosis, belonging to the field of biomedical technology. The application of the reagent that inhibits ADNP gene expression or ADNP protein activity in the preparation of drugs for treating renal fibrosis. This invention effectively knocks down or knocks out the ADNP gene in renal tubular epithelial cells, objectively investigates the effects of ADNP deficiency on a series of phenotypes in HK-2 cells, and confirms that ADNP can inhibit EMT and renal fibrosis in HK-2 cells. Drugs that target and knock down or knock out the ADNP gene in human kidneys can be developed to delay the progression of renal fibrosis.

This invention relates to the field of medical data processing technology, and discloses an Alzheimer's disease prediction method, system, device, and medium, comprising: obtaining spectral data of a target group in a non-invasive manner; training an Alzheimer's disease prediction model based on the spectral data; the target group includes healthy individuals and individuals with Alzheimer's disease. This invention non-invasively obtains samples from the target group, utilizing the advantages of laser-induced breakdown spectroscopy (LAS) for simultaneous detection and analysis of all elements at high speed. It achieves qualitative or quantitative analysis of the chemical composition of material surfaces by measuring the emission spectrum of micro-plasma, accurately and rapidly obtaining spectral data of the target group. The Alzheimer's disease prediction model trained based on the spectral data can effectively assist doctors in early screening of individuals, enabling early intervention for patients with early-stage Alzheimer's disease, and has broad application prospects.

The invention relates to a traditional Chinese medicine composition for preventing and treating ocular surface injury caused by xerophthalmia and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-40 parts of spica prunellae, 20-40 parts of radix astragali, 5-25 parts of rhizoma polygonati, 5-25 parts of folium mori and 5-25 parts of fructus crataegi. Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention consists of five medicinal and edible Chinese herbal medicines, is simple and convenient to take, safe and free from side effects, and can be popularized and used as a medicine for preventing and treating xerophthalmia. The traditional Chinese medicine composition disclosed by the invention can be used for remarkably inhibiting the corneal injury related to the xerophthalmia, maintaining the number of conjunctival goblet cells and providing new treatment for relieving the ocular surface injury of the xerophthalmia.

The invention belongs to the technical field of biological medicines, and particularly relates to application of an MYC mRNA translation inhibitor in preparation of a medicine for preventing and / or treating osteoarthritis. The MYC mRNA translation inhibitor is selected from biological materials capable of inhibiting or blocking the MYC mRNA translation process, reducing the MYC protein synthesis efficiency or interfering the MYC mRNA steady state level. The invention provides a novel molecular target capable of being used for treating osteoarthritis and a medicine application scheme of the molecular target.

The present application relates to the technical field of medicine, especially relates to application of a small molecule compound LZ-09 in preparation of a medicine for treating and / or preventing multiple sclerosis. The present application adopts H2O2 damage OLN-93 cells as a nerve cell oxidative stress model, and the result shows that LZ-09 treatment significantly weakens the cell viability decrease caused by H2O2. The classic EAE model is made by using MOG35-55 to induce C57BL / 6 mice, and it is found that after LZ-09 intervention, the mouse neurological deficit symptom score is significantly reduced, and the disease progression is delayed, and spinal cord tissue HE and LFB staining find that the inflammation infiltration and demyelination are reduced. Therefore, the compound can effectively alleviate the symptoms of multiple sclerosis, can be used as a medicine for treating multiple sclerosis, and has wide development and application prospect.

The utility model relates to rare earth hydrogen storage alloy or quick -setting neodymium iron boron alloy smelting auxiliary equipment technical field, specific, relate to a kind of rare earth metal powder explosion -proof dust collecting device, including shell, filter bag chamber, backflush mechanism, dust-containing gas inlet, purified gas outlet, still include inert gas supply gas path, explosion suppressor, explosion vent. Nitrogen gas path is introduced on the one hand reduces the oxygen content in dust collecting device, makes oxygen concentration reduce, reduces the oxidation reaction of rare earth metal, reduces the generation of heat. On the other hand, nitrogen in nitrogen gas path low pressure gas path is obtained by high-pressure liquid nitrogen throttling pressure reduction, temperature is lower, it is favorable to reduce the temperature in dust collecting device. The introduction of nitrogen gas path greatly reduces the explosion risk, this is the conventional working process. By introducing explosion suppressor, explosion vent, cooling can be carried out when temperature is too high and pressure relief after explosion, to slow down the progress of explosion and protect the entire device after explosion.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The invention discloses a fusion polypeptide RAT-1 and application thereof in hypertension treatment. The topological structure of the fusion polypeptide is a kidney targeting head-ACE2 functional segment-MMP responsive connexon-AT1 receptor antagonism segment, and the full-length sequence is as shown in SEQ ID No: 1. The kidney targeting head can be specifically combined with megalin receptors of renal tubular epithelial cells to realize kidney targeting delivery; the ACE2 functional segment can efficiently degrade angiotensin II; the MMP responsive connexon is specifically cut in a focus microenvironment, and an AT1 receptor antagonism segment is released; the AT1 receptor antagonist segment can block the receptor signal channel of angiotensin II. The fusion polypeptide has good plasma stability, shows a powerful and long-acting antihypertensive effect in a spontaneous hypertension rat model, is remarkable in kidney targeting, and can relieve renal fibrosis and protect podocyte functions. The fusion polypeptide disclosed by the invention realizes a synergistic effect of targeted delivery, enzymolysis catalysis, response release and receptor antagonism, and can be used for preparing hypertension treatment medicines and kidney protection medicines.

The application provides a preparation method of a compound SS-23 and an application of the compound SS-23 in preparing medicines for preventing and / or treating atherosclerosis, and belongs to the technical field of chemical medicines. The compound SS-23 is a compound shown in formula I or a pharmaceutically acceptable salt thereof. The phenolic acid glyceride compound SS-23 is obtained by separation and purification from Sparganium stoloniferum Buch. The compound can play a role in preventing and / or treating atherosclerosis by regulating blood lipid levels, reducing plaque area and improving blood vessel function. The compound SS-23 has significant potential in preventing and / or treating atherosclerosis, provides a new treatment strategy for clinic, and has a good application prospect. Formula I.

The present invention provides synthetic compounds having magical biological activity, compositions comprising them, processes for their preparation and their use in the treatment of diseases, symptoms and conditions.

This invention belongs to the field of biomedical technology and discloses the application of calcium-activated chloride channel AN01 / TMEM16A in the prevention and treatment of atherosclerosis. This invention also discloses the application of ANO1 promoters in the preparation of drugs for the treatment or prevention of atherosclerosis. Through research, this invention has found that the loss of ANO1 in vascular smooth muscle cells exacerbates the instability of atherosclerotic plaques, while overexpression of ANO1 can enhance the stability of atherosclerotic plaques and delay the progression of atherosclerosis. ANO1 in smooth muscle cells is one of the key drivers of atherosclerosis progression. This invention clarifies that targeting the non-ion channel function of ANO1 protein has important clinical translational value for screening drugs for the treatment or prevention of atherosclerosis.

The utility model belongs to the medical auxiliary device technical field, specifically is a kind of spine orthosis, including fixed base;The fixed base top side wall is fixed with first fixed plate;The first fixed plate top side wall is equipped with orthopedic plate;The fixed base top side wall is fixed with second fixed plate;The second fixed plate top side wall is equipped with limit stop;By setting orthopedic plate, second fixed plate, limit stop, telescopic link and movable ball block can adjust the radian of orthopedic plate, so that orthopedic plate can adapt to the spinal column form of different patients, to more effectively correct scoliosis, humpback etc. Bad body posture, and adjustable radian design, make orthopedic plate can adapt to the spinal column form and bending degree of different patients, provide more personalized correction scheme, help to slow down the progress of spinal deformity, ensure the maximization of correction effect, reduce unnecessary discomfort or stress, and provide stability and support in subsequent treatment.

Disclosed are compounds of Formula (I): (I), or a stereoisomer, tautomer or salt thereof, wherein R is as defined herein. Also disclosed are methods of using such compounds to reduce the levels of an Ikaros protein, a Helios protein, an Ailos protein, and an Eos protein; and pharmaceutical compositions comprising such compounds. These compounds are useful for the treatment of viral infections and proliferative disorders, such as cancer. (I)

The present disclosure features compositions and methods useful for treating a condition for which deamination of adenosine in RNA results in a therapeutic outcome in a subject in need thereof.

The invention relates to application of UBR5 in treatment and prognosis evaluation of bladder cancer. According to the invention, the key carcinogenic regulation effect of the UBR5 in NMIBC is determined, the high expression of the UBR5 can predict early recurrence and poor prognosis, and the value of the UBR5 as a biomarker for guiding a future precise treatment strategy is highlighted. Targeted UBR5 can effectively inhibit tumor cell proliferation and movement ability, and manifests the potential of the targeted UBR5 as a therapeutic target. By inhibiting the UBR5 or reducing the biological activity of the UBR5, the development of the NMIBC disease can be obviously delayed, the prognosis is improved, the survival rate of a patient is prolonged, the prognosis is improved, and the potential of developing a personalized treatment strategy for a high-risk NMIBC patient by targeting the UBR5 is manifested; the invention provides sufficient scientific basis and theoretical basis for exploring new bladder cancer diagnosis, prognosis judgment and treatment molecular targets and developing new targeted drugs, is helpful for better realizing accurate treatment, and has important social value and scientific significance.