Traditional Chinese medicine composition for influencing gastric mucosa oncogene expression level

An oncogene and expression level technology, applied in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as non-targeted treatment plans, and achieve the effect of improving gastric mucosal atrophy, better curative effect, and delaying the atrophy process.

Active Publication Date: 2022-05-13
南京市溧水区中医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine treatment often focuses on eradicating HP and symptomatic treatment, and there is no specific targeted treatment plan

Method used

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  • Traditional Chinese medicine composition for influencing gastric mucosa oncogene expression level
  • Traditional Chinese medicine composition for influencing gastric mucosa oncogene expression level
  • Traditional Chinese medicine composition for influencing gastric mucosa oncogene expression level

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] In the examples listed in this specification, the specific proportions of astragalus 12g, ganoderma lucidum 8g, coix seed 15g, tangerine peel 8g, shijianchuan 15g, and hedyotis diffusa 15g are used.

[0022] 1 Research implementation content and methods

[0023] 1.1 Case source and grouping

[0024] The research cases in this project come from 68 patients with CAG (Spleen and Stomach Weakness Syndrome) in the Department of Gastroenterology, Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine. They were randomly divided into 34 cases in each group.

[0025] Taking moluodan as the reference drug, according to the pre-clinical observation, the effective rate of the traditional Chinese medicine composition of the present invention is estimated to be μl=90%, and it is reported in the literature that the effective ratio of moluodan as a control is μ2=60%. Set two-sided test α = 0.05, β = 0.2, Z α =1.96, Z β =0.84, according to the statistica...

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Abstract

The invention belongs to the field of application of a traditional Chinese medicine in treating diseases caused by the influence of the expression level of an oncogene mutant p53 and an oncogene MDM2 on the gastric mucosa of a patient, and particularly relates to specific application of the traditional Chinese medicine in the diseases caused by the mechanism, such as chronic atrophic gastritis. According to the technical scheme, the traditional Chinese medicine composition capable of influencing the oncogene expression level of the gastric mucosa is prepared from the following components in parts by weight: 400 to 3000 parts of radix astragali seu hedysari, 500 to 1500 parts of lucid ganoderma, 300 to 4000 parts of semen coicis, 500 to 1500 parts of pericarpium citri reticulatae, 300 to 4000 parts of herba salviae chinensis and 300 to 4000 parts of herba hedyotidis diffusae. Immunohistochemical analysis shows that by inhibiting expression correlation of oncogene mutant p53 and MDM2, the medicine has a good curative effect on patients with chronic atrophic gastritis, and particularly has a better curative effect on improving gastral cavity fullness or dull pain, stomach pressing or warming, thin stool, lassitude and weakness, short breath and laziness to speak and the like compared with a gold standard medicine morhodamine; the pathological states of gastric mucosa atrophy, intestinal metaplasia, chronic inflammation, activity and the like can be effectively improved, and the atrophy process is delayed.

Description

technical field [0001] The invention belongs to the field of application of traditional Chinese medicine in the treatment of diseases caused by the expression levels of oncogene mutant p53 and oncogene MDM2 in the gastric mucosa of patients, especially in diseases caused by the aforementioned mechanism, such as chronic atrophic gastritis (spleen-stomach weakness syndrome) specific applications in. Background technique [0002] Ge Qian and other scholars pointed out in "Research Progress on the Correlation between p53 and Gastrointestinal Malignancies" "Chinese Journal of Integrated Traditional Chinese and Western Medicine Digestion" 2016 No. 10 that p53 can be divided into wild tumor suppressor genotype (wt-p53) and mutation Oncogenotype (mt-p53). Oncogene mutants p53 and MDM2 are related to cell proliferation and apoptosis, and their protein expression levels are closely related to the occurrence and development of chronic atrophic gastritis (hereinafter referred to as CAG...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P1/04A61P1/14A61P1/00
CPCA61K36/481A61K36/074A61K36/8994A61K36/752A61K36/537A61K36/748A61P1/04A61P1/14A61P1/00A61K2300/00Y02A50/30
Inventor 陆敏樊欣钰
Owner 南京市溧水区中医院
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