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Traditional Chinese medicine lipid-lowering composition as well as preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine lipid-lowering composition and preparation thereof, can solve the problems of long-term application of side effect drugs and the like

Active Publication Date: 2019-12-31
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the treatment of hyperlipidemia still relies on drug therapy, and the drugs used can be mainly divided into five categories: statins, fibrates, nicotinic acid, bile acid chelating agents, and cholesterol absorption inhibitors. The main reasons for the long-term use of drugs

Method used

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  • Traditional Chinese medicine lipid-lowering composition as well as preparation method and application thereof
  • Traditional Chinese medicine lipid-lowering composition as well as preparation method and application thereof
  • Traditional Chinese medicine lipid-lowering composition as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0029] Prescription: a Chinese medicine lipid-lowering composition, made of the following Chinese medicines: Polygonatum 400g, Coptis Rhizoma 100g, Jiaogulan 300g, Pueraria 300g, Hawthorn 260g;

[0030] Preparation method: Weigh the above five traditional Chinese medicines in proportion, take Coptis chinensis and add 6 times its mass of water to decoct twice, each decocting time is 1h; ~1.30 thick ointment for later use; add 5 times the amount of water to the remaining four traditional Chinese medicines each time and decoct twice, filter and combine the filtrate and concentrate at 55°C to form a relative density of 1.25~1.30 thick ointment; mix the above two thick ointments Vacuum drying method is used to dry the dry paste respectively, the drying temperature is 60°C, and the vacuum degree is -0.07Mpa; then the dry paste is crushed separately, and the dry paste powder is obtained after mixing, and the paste is added to the above dry paste powder Refined, prepared into wet gran...

Embodiment 2

[0032] Prescription: a traditional Chinese medicine lipid-lowering composition, made of the following traditional Chinese medicines: Polygonatum 500g, Coptidis 200g, Jiaogulan 400g, Pueraria 400g, Hawthorn 360g.

[0033] Preparation method: Weigh the above five traditional Chinese medicines in proportion, take Coptis chinensis and add 12 times its mass of water to decoct twice, and the decoction time is 2 hours; 1.30 thick ointment for later use; add 10 times the mass of water to the remaining four traditional Chinese medicines each time and decoct twice, filter and combine the filtrate and concentrate at 65°C to form a thick ointment with a relative density of 1.25-1.30; separate the above two kinds of thick ointments Vacuum drying is used to obtain a dry cream, the drying temperature is 80°C, and the vacuum degree is 0.08Mpa; the dry cream powder is mixed after being crushed separately, and then the dry cream powder is directly filled into capsules to obtain capsules.

Embodiment 3

[0035] Prescription: a traditional Chinese medicine lipid-lowering composition made of the following traditional Chinese medicines: Polygonatum 420g, Coptidis 120g, Jiaogulan 320g, Pueraria 320g, Hawthorn 300g.

[0036]Preparation method: Weigh the above five traditional Chinese medicines in proportion, take Coptis rhizome and add water to decoct twice. 8 times, and the decoction time is 1.5h; after filtering and combining the filtrates, concentrate at 60°C to form a thick paste with a relative density of 1.25-1.30 for later use; the remaining four traditional Chinese medicines are combined and decocted twice, and the amount of water added for the first decoction is its mass 8 times of its weight, and the decocting time is 2 hours; the second decoction adds 6 times of its mass, and the decoction time is 1.5 hours; after filtering and combining the filtrates, it is concentrated at 60°C to a thick paste with a relative density of 1.25 to 1.30; The above two thick pastes are drie...

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Abstract

The invention provides a traditional Chinese medicine lipid-lowering composition as well as a preparation method and an application thereof. The traditional Chinese medicine lipid-lowering compositionis prepared from the following traditional Chinese medicines in parts by weight: 400-500 parts of rhizoma polygonati, 100-200 parts of rhizoma coptidis, 300-400 parts of gynostemma pentaphylla, 300-400 parts of radix puerariae and 260-360 parts of hawthorn. The preparation method comprises the following steps: weighing the five traditional Chinese medicines in proportion, adding water into rhizoma coptidis, decocting the material, filtering the material, combining filtrates, and concentrating into thick paste for later use; adding water into the other four traditional Chinese medicines, decocting the materials, filtering the materials, combining filtrates, and concentrating into the thick paste; and respectively drying and crushing the two kinds of thick paste to obtain dry paste powder,then adding dextrin, steviosin and aspartame, and preparing and forming the traditional Chinese medicine lipid-lowering composition. The traditional Chinese medicine lipid-lowering composition has theeffects of removing blood stasis and turbidity and promoting blood circulation to remove meridian obstruction, and is remarkable in clinical treatment effect on qi stagnation and blood stasis type hyperlipemia.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine lipid-lowering composition and its preparation method and application. Background technique [0002] Over the past 20 years, with the improvement of people's living conditions, the prevalence of hyperlipidemia has increased year by year. According to the latest data from the survey of "Chinese Resident Nutrition and Health Status", the prevalence of hyperlipidemia among adults in China is 18.6 %, about 160 million people. Changes in cholesterol levels and mortality in the Chinese population have increased by 6 times in the past 15 years, especially for men aged 35 to 45. When they are in their prime of life, the mortality rate of acute myocardial infarction in the population has increased by 154%. It can be seen that hyperlipidemia has become a major problem threatening human health. [0003] Abnormal fat metabolism or operation makes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P3/06
CPCA61K36/424A61K36/488A61K36/718A61K36/734A61K36/8969A61K2236/331A61K2236/39A61P3/06A61K2300/00
Inventor 向大雄罗世林刘新义李文群李健和朱运贵胡雄彬杨永玉
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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