Application of syringin in preparing drugs for treating cardiovascular and cerebrovascular diseases

A technology of cardiovascular and cerebrovascular diseases, syringin, applied in the field of medicine, can solve problems such as undiscovered cardiovascular and cerebrovascular diseases

Inactive Publication Date: 2009-12-09
潘书洋 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No literature reports on cardiovascular and c

Method used

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  • Application of syringin in preparing drugs for treating cardiovascular and cerebrovascular diseases
  • Application of syringin in preparing drugs for treating cardiovascular and cerebrovascular diseases
  • Application of syringin in preparing drugs for treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Take syringin, adopt the well-known preparation method of infusion in this technical field, prepare syringin sodium chloride injection and syringin glucose injection: 50 mg syringin, 2.25 g sodium chloride, make syringin Sodium chloride injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day; Syringin 50mg, glucose 12.5g, made into syringin glucose injection, its specification is 500ml, intravenous injection, every 1 bottle at a time, once a day.

Embodiment 2

[0073] Example 2: Take 20 g of syringin, add appropriate amount of water for injection, heat in a water bath to dissolve, then add mannitol for injection equivalent to 10-15% of syringin, sterilize and filter, measure the content, and pack 1000 sticks, 10mg / bottle, sealed, ready to use. Intravenous injection, 40mg each time, once a day.

Embodiment 3

[0075] Take 200 g of syringin and 32 ml of 10% hypromellose. Adopt the well-known capsule preparation method in the technical field to make 1000 capsules, each containing 200 mg of syringin. Take orally, 1 capsule each time, once a day.

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PUM

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Abstract

The invention relates to application of syringin in preparing drug combination for treating cardiovascular and cerebrovascular diseases. The syringin preparation is safe and nontoxic and has strong pharmacological action and good drug effect, thereby indicating bright prospect in drugs; the syringin preparation is simple in preparing process, has no toxic side effects and can be in oral forms such as tablets, pills, capsules and the like, or in injectable forms such as powder-injection, instillations and the like; the drugs prepared by the syringin can evidently lessen the degree and scope of myocardial ischemia caused by the anterior descending branch of canine coronary artery, reduce the myocardial oxygen consumption index, obviously withstand barium chloride induced arrhythmia in rats and reduce the cerebral infarct area of focal cerebral ischemia in rats; the above effects show that the drugs have obvious effects against arrhythmia, myocardial ischemia and cerebral ischemia. The drugs can be clinically used for preventing and treating coronary diseases, angina, stroke and cerebral infarct, etc.

Description

Technical field: [0001] The invention relates to the application of syringin in the preparation of medicines for treating cardiovascular and cerebrovascular diseases, which belongs to the technical field of medicine. Background technique [0002] The molecular formula of syringin is: C 17 h 24 o 9 , Molecular weight: 372.36. Plants such as Chinese medicine Jiubing, Acanthopanax, Saussurea officinalis, Pamarin, clove, mistletoe, Acanthopanax bark, Angora radix, Zushima and other plants all contain syringin. Syringin has pharmacological activities such as regulating the body's immunity, protecting the liver, anti-inflammation, lowering blood pressure, improving tolerance, and lowering blood sugar. So far, no literature reports on cardiovascular and cerebrovascular diseases have been found. Contents of the invention [0003] The purpose of the present invention is to provide the application of syringin in the preparation of medicine for treating cardiovascular and cerebr...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P9/00A61P9/10A61P3/06
Inventor 李超生潘书洋姚程文
Owner 潘书洋
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