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Preparation method and application of pedunculoside

A technology of holothin and total saponins, which is applied in the field of preparation and application of holothrin, can solve the problems of high cost, complicated operation, small output and the like

Active Publication Date: 2007-09-12
李超生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The deficiencies of the prior art are that highly toxic chloroform needs to be degreased and separated by silica gel column chromatography, the output is small, the cycle is long, the cost is high, the operation is complicated, and the process conditions cannot meet the needs of industrial production

Method used

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  • Preparation method and application of pedunculoside
  • Preparation method and application of pedunculoside
  • Preparation method and application of pedunculoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: Rescue 2000g of Bing coarse powder, reflux extraction with 6 times of 80% ethanol three times, extract for 2, 1, and 1 hour respectively, filter, combine the filtrates, concentrate to extract, add 6000ml of water, heat in a water bath, and stir , standing overnight, filtered to obtain precipitate and filtrate. The precipitate is extracted with 50-95% ethanol under reflux, filtered, the filtrate is concentrated, placed, filtered, and the precipitate is dried to obtain the total saponins, and the total saponins are crystallized by adding 10-100 times of 50-95% ethanol to obtain a part of Ilex ilex Glycosides. Concentrate the filtrate to 1000ml, let it cool to room temperature, filter, wash the precipitate three times with appropriate amount of water, dry, crystallize with 10-50 times the amount of 50-95% ethanol, and obtain another part of the coarse crystal of glucoside, twice The prepared pelicosides are combined, and recrystallized multiple times with 10-10...

Embodiment 2

[0095] Take the pelicoside prepared by the method of Example 1, and adopt the well-known preparation method of the infusion solution in the technical field to prepare the pelicoside sodium chloride injection and the pelicoside glucose injection: the pelicoside 40 mg, Sodium Chloride 2.25g, made into Pelicoside Sodium Chloride Injection, the specification is 500ml, intravenous injection, 1 bottle each time, once a day; 40mg of Pelicoside, glucose 12.5g, made into Ilex Glucoside injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day.

Embodiment 3

[0096] Example 3: Take 20 g of glucoside prepared by the method of Example 1, add an appropriate amount of water for injection, adjust the pH value to 7 with sodium carbonate, stir and dissolve, and then add an amount equivalent to 10-15% of glucoside Mannitol for injection is sterilized and filtered, its content is determined, and it is packaged in 1000 tubes, 20 mg per tube, sealed, and ready to be obtained. Intravenous injection, 40mg each time, once a day.

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Abstract

This invention relates to ilexin, drug combination of ilexin and its extraction method, which is used to treat CHD, angina pectoris, stroke, cardiac infarction and other cerebral vascular diseases. It uses ethanol for extraction, adds water into the extract, centrifuges to get the sediments and supernatant. Sediments are added 50-95% ethanol for extraction and filtration, the liquid is concentrated, placed and filtrated, and the sediments are dried to get a part of total saponin, the saponin is crystallized by ethanol to get a part of ilexin. The supernatant is enriched and centrifuged for the sediments, which is washed with appropriate water and crystallized by ethanol after dried to get another part of ilxin. Two parts of ilxin are put together and recrystallized for several times to get the pure ilxin, which content can be more than 98.0%.

Description

technical field [0001] The invention relates to a medicine for treating diseases of the cardiovascular and cerebrovascular systems, a health food and a preparation method thereof, in particular to the composition of the active ingredient of the traditional Chinese medicine, glucoside, the medicine containing glucoside, and the health food and their corresponding preparation methods. Background technique [0002] Jiubing is the bark of Ilex rotunda Thunb., a plant in the Ilex family Ilex family. It is mainly produced in Guangxi and Guangdong provinces. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. For colds, tonsillitis, sore throat, acute gastroenteritis, rheumatic bone pain; external use for bruises, carbuncle furuncle sores, traumatic bleeding, burns and scalds. The chemical components mainly contain triterpenoid saponins, flavonoid glycosides, phenols, tannins, etc., and the content of saponins is relatively high, abou...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07J53/00A61K31/704A61P9/00A61K36/185A61K129/00
Inventor 李超生
Owner 李超生
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