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Method of preparing jiubiying total saponins and the application thereof

A technology of total saponins and salvage, which is applied in the fields of medicines and health foods for treating cardiovascular and cerebrovascular diseases and their preparation, and can solve problems such as unclear effective parts and the like

Inactive Publication Date: 2007-09-12
潘书洋 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the alcohol extract of Jiubingying is a crude preparation, its exact effective part is not clear in the prior art

Method used

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  • Method of preparing jiubiying total saponins and the application thereof
  • Method of preparing jiubiying total saponins and the application thereof
  • Method of preparing jiubiying total saponins and the application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Example 1: Rescue 2000g of Bing coarse powder, reflux extraction with 6 times 80% ethanol three times, extract for 2, 1, 1 hour respectively, filter, combine the filtrates, concentrate to extract, add 6000ml of water, heat in a water bath, stir , standing overnight, filtered to obtain precipitate and filtrate. The precipitate is extracted with 50-95% ethanol under reflux, filtered, the filtrate is concentrated, placed, filtered, and the precipitate is dried to obtain a part of total saponins. The filtrate was concentrated to 1000ml, allowed to cool to room temperature, filtered, and the precipitate was washed three times with an appropriate amount of water, and dried to obtain another part of total saponins. The total saponins obtained twice were combined to obtain 120g of total saponins from Bing. According to the law, the total saponin content is 85%.

Embodiment 2

[0103] Take the total saponins of Jiubing prepared by the method of Example 1, adopt the preparation method of infusion solution known in the art, and prepare the total saponins of Jiubing sodium chloride injection and the total saponins of Jiubing glucose injection: Jiubing total saponins Total saponins 60mg, sodium chloride 2.25g, made into Jiubing total saponins sodium chloride injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day; Jiubing total saponins 60mg, glucose 12.5g , make Jiubing Total Saponin Glucose Injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day.

Embodiment 3

[0104] Embodiment 3: Take 30 g of total saponins of jiubing prepared by the method of example 1, add appropriate amount of water for injection, adjust the pH value to 7 with sodium carbonate, stir and dissolve, and add 10-15 g of total saponins of jiubing equivalent to The % amount of mannitol for injection is sterilized and filtered, the content is determined, and 1000 pieces are divided into 30 mg / piece, sealed, and the product is obtained. Intravenous injection, each 60mg, once a day.

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Abstract

The present invention relates to total ovateleaf holly saponin for treating coronary heart disease, angina, apoplexy and other cardiac and cerebral vascular diseases, its medicine composition and extracting process. Ovateleaf holly bark is extracted with alcohol, and the extract is added with water and centrifuged to obtain precipitate and supernatant. The precipitate is alcohol reflux extracted, and the extract is treated through filtering, filtrate concentrating, drying and other steps to obtain the first part of total saponin. The supernatant is treated through concentrating, centrifuging, water washing of the precipitate and drying to obtain the second part of total saponin. These two parts of total saponin are merged to obtain the total ovateleaf holly saponin, which may be added with supplementary material and further treated to obtain various kinds of oral preparations and injection.

Description

technical field [0001] The invention relates to a medicine for treating diseases of the cardiovascular and cerebrovascular systems, a health food and a preparation method thereof, in particular to the total saponins of the effective part of the traditional Chinese medicine jiubing, the medicine containing the total saponins of jiubing and the preparation method thereof. Compositions and their corresponding methods of preparation. Background technique [0002] Jiubiying is the bark of Ilex rotunda Thunb., a plant of the genus Ilex in the Ilex family. It is mainly produced in Guangxi and Guangdong provinces. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. For colds, tonsillitis, sore throat, acute gastroenteritis, rheumatic bone pain; external use for bruises, carbuncle furuncle sores, traumatic bleeding, burns and scalds. The chemical components mainly contain triterpenoid saponins, flavonoid glycosides, phenols, tannins, et...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P9/00A61K129/00
Inventor 李超生
Owner 潘书洋
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