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Application of nicotinamide riboside in the preparation of drugs for the treatment of cerebral ischemic diseases

A technology for nicotinamide ribose and drug preparation, which is applied in the field of compounds to achieve the effects of reducing the size of cerebral infarction, significantly protecting against cerebral ischemia, and having broad application prospects.

Active Publication Date: 2018-11-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no literature report on the protective effect of nicotinamide riboside on cerebral ischemic injury

Method used

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  • Application of nicotinamide riboside in the preparation of drugs for the treatment of cerebral ischemic diseases
  • Application of nicotinamide riboside in the preparation of drugs for the treatment of cerebral ischemic diseases
  • Application of nicotinamide riboside in the preparation of drugs for the treatment of cerebral ischemic diseases

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Experimental program
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Embodiment 1

[0018] 1. Method

[0019] Rats (Sprague-Dawley rats, weighing about 250 g, Shanghai Slack Experimental Animal Co., Ltd.) were used to prepare a permanent cerebral ischemic injury model. The process is as follows: rats were anesthetized, the skull was opened, and the middle cerebral artery was electrocoagulated directly under visual observation, resulting in blockage of the left middle cerebral artery. Thirty minutes later, the rats were intraperitoneally injected with nicotinamide riboside (30 mg / kg, purchased from Shanghai Hanxiang Biotechnology Co., Ltd.). The control group was given 0.9% normal saline for intraperitoneal injection. The skull was reset and the skin was sutured, and the rat model of permanent cerebral ischemia caused by occlusion of the middle cerebral artery was successfully prepared. Twenty-four hours after middle cerebral artery occlusion, the cerebral infarct area was detected. The volume of cerebral infarction was detected by 2,3,5-triphenyltetrazoliu...

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Abstract

The invention relates to application of nicotinamide riboside to preparing medicine for treating cerebral ischemic diseases. The application has the advantages that influence of the nicotinamide riboside on cerebral infarction areas of cerebral ischemic models formed in the brains of rats due to artery electrocoagulation occlusion is studied, the cerebral infarction areas can be obviously reduced by nicotinamide riboside administration as proved by the study, obvious cerebral ischemic protection effects can be realized by the nicotinamide riboside as shown by the study, brain injury due to cerebral ischemia can be prevented and treated, and accordingly the nicotinamide riboside has a broad application prospect in the aspects of preparing related medicine for cerebral ischemic injury and / or cerebral infarction.

Description

technical field [0001] The present invention relates to a new application of the compound, in particular to the application of nicotinamide riboside in the preparation of medicines for treating cerebral ischemic diseases. Background technique [0002] Nicotinamide riboside is a nucleotide compound with a CAS number of 1341-23-7 and a structural formula of: [0003] [0004] Foreign reports have found that nicotinamide riboside has protective effects in obesity, hearing loss, senile neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and can improve cognitive decline. Chinese patent document CN201510098227.9, published on 2015.05.20, discloses the application of nicotinamide riboside in the preparation of drugs for the treatment of non-alcoholic steatohepatitis. Through animal models of non-alcoholic steatohepatitis, it is confirmed that nicotinamide riboside can reduce The liver lipid content, liver inflammation and liver fibrosis in an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/706A61P9/10
Inventor 缪朝玉王培管云枫徐添颖李志勇
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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