New application of traditional Chinese medicine composition to treating and/or preventing stroke

A composition and a technology for new uses, applied to the new use in the treatment and/or prevention of stroke, in the field of traditional Chinese medicine compositions, can solve the problems such as the role of traditional Chinese medicine compound preparations in the treatment and/or prevention of stroke, etc., which are not indicated, and achieve the reduction of cerebral infarction. range, no toxic side effects, water content reduction effect

Inactive Publication Date: 2016-06-29
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] ZL201010103301.9 "A compound traditional Chinese medicine preparation for the treatment of hepatitis". , chronic hepatitis, persistent hepatitis, does not suggest that the Chinese herbal compound preparation has the effect of treating and / or preventing stroke

Method used

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  • New application of traditional Chinese medicine composition to treating and/or preventing stroke
  • New application of traditional Chinese medicine composition to treating and/or preventing stroke
  • New application of traditional Chinese medicine composition to treating and/or preventing stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of extract 1

[0038] Weigh the following raw materials: Panax notoginseng 230g, Chicken bone grass 420g, Desmodium sativa 140g, Artificial bezoar 22g, Pig bile powder 1.3g, Snake bile 6g.

[0039] Grind Panax notoginseng into coarse powder, impregnate with 50% ethanol for 48 hours, infiltrate at a rate of 1 mL per kilogram per minute, collect percolation fluid equivalent to 10 times the amount of medicinal materials, filter, concentrate the filtrate, dry, and pulverize to obtain Panax notoginseng extract Grind the artificial bezoar into fine powder, and set aside; add water to decoct Jigucao and Guangshencao twice, add water of 10 times the total weight of the two traditional Chinese medicines each time, for the first time for 3 hours, and for the second time After 2 hours, combine the decoctions, filter, concentrate the filtrate, dry, and pulverize to obtain the extracts of Gallus japonicus and Desmodium sativa, and set aside; combine snake...

Embodiment 2

[0040] Embodiment 2: the preparation of extract 2

[0041] The following raw materials were weighed: 250g Panax notoginseng, 460g Chicken Bone Grass, 152g Desmodium sativa, 24g artificial bezoar, 1.5g pig bile powder, and 7g snake bile.

[0042] Grind Panax notoginseng into coarse powder, impregnate it with 50% ethanol for 24 hours, percolate at a rate of 2 mL per kilogram per minute, collect percolation liquid equivalent to 10 times the amount of medicinal materials, filter, concentrate the filtrate, dry, and pulverize to obtain Panax notoginseng extract Grind the artificial bezoar into fine powder, and set aside; add water to decoct Jigucao and Guangshencao twice, add water of 8 times the total weight of the two traditional Chinese medicines each time, and combine the decoctions for 2 hours each time , filtered, the filtrate was concentrated, dried, and pulverized to obtain the extracts of Gallus japonicus and Desmodium sativa, and set aside; mixing snake bile, pig gall powd...

Embodiment 3

[0043] Embodiment 3: the preparation of extract 3

[0044] Weigh the following raw materials: Panax notoginseng 230g, Chicken bone grass 420g, Desmodium sativa 140g, Artificial bezoar 22g, Pig bile powder 1.3g, Snake bile 6g.

[0045] Panax notoginseng is crushed into coarse powder, impregnated with 30% ethanol for 72 hours, percolated at a rate of 10 mL per kilogram per minute, and the percolation liquid equivalent to 10 times the amount of medicinal materials is collected, filtered, the filtrate is concentrated, dried, and pulverized to obtain notoginseng extract, set aside; crush the artificial bezoar into fine powder, set aside; add water to decoct Jigucao and Guangshencao twice, add water 12 times the total weight of the two traditional Chinese medicines each time, the first time for 2 hours, and the second time The second time is 1 hour, the decoction is combined, filtered, the filtrate is concentrated, dried, and pulverized to obtain the extracts of Jigucao and Desmodiu...

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Abstract

The invention discloses a new application of a traditional Chinese medicine composition in treating and / or preventing stroke and a preparation method thereof. The composition is prepared from medicinal materials such as notoginseng, chicken bone grass, golden grass, artificial bezoar, pig bile powder and snake bile. The invention also provides a preparation method of the traditional Chinese medicine composition for treating stroke. The composition provided by the invention can obviously improve the neurobehavioral disorder of rats with cerebral infarction, reduce the scope of cerebral infarction in rats with focal cerebral ischemia, reduce the water content of brain tissue, and reduce focal cerebral ischemia-reperfusion injury in rats. Has a therapeutic effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a new application of a traditional Chinese medicine composition in treating and / or preventing apoplexy. Background technique [0002] Stroke is a common and refractory disease that seriously endangers human health and life safety. Motherland medicine lists it as the first of the four difficult diseases of "wind, cure, phlegm, and diaphragm", and there are obvious three highs (high morbidity, high disability rate, and high mortality) phenomenon. Therefore, it is urgent to improve the treatment and prevention level of apoplexy and reduce the incidence rate, disability rate and mortality rate of apoplexy. Stroke is divided into two categories: ischemic stroke (accounting for 85% of all cerebral strokes) and hemorrhagic stroke (accounting for 15% of all cerebral strokes), namely cerebral hemorrhage. [0003] Ischemic stroke, also known as ischemic stroke and cerebral inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P9/10A61P7/04A61K35/413A61K35/583
CPCA61K36/258A61K35/413A61K35/583A61K36/48A61K2236/331A61K2236/333A61K2236/39
Inventor 吕林艳刘冠萍郑志远朱小凤钟杰敏林艳英
Owner GUANGXI WUZHOU PHARMA GRP
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