Preparation method and application for pedunculoside II

It is a technology with glucoside and cardiovascular and cerebrovascular. It is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc. It can solve the problems of complex operation, long cycle, and process conditions that cannot meet the needs of industrial production.

Inactive Publication Date: 2008-01-09
李超生 +1
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The deficiencies of the prior art are that highly toxic chloroform needs to be degreased and separated by silica gel column chromatography, the output is small, the cycle is long, the cost is high, the operation is complicated, and the process conditions cannot meet the needs of industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application for pedunculoside II
  • Preparation method and application for pedunculoside II
  • Preparation method and application for pedunculoside II

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Example 1: Rescue 2000g of Bing coarse powder, reflux extraction with 6 times 80% ethanol three times, extract for 2, 1, 1 hour respectively, filter, combine the filtrates, concentrate to extract, add 6000ml of water, heat in a water bath, stir , stand overnight, filter, the filtrate is concentrated to 1000ml, let cool to room temperature, filter, the precipitate is washed three times with an appropriate amount of water, dried, and crystallized with 10-50 times the amount of 50-95% ethanol to obtain crude glucoside Crystal, followed by repeated crystallization with 10-50 times the amount of 50-95% ethanol to obtain pure glucoside with a yield of 1.38%. According to the law, the content is 98.59%.

Embodiment 2

[0103] Take the pelicoside prepared by the method of Example 1, and adopt the well-known preparation method of the infusion solution in the technical field to prepare the pelicoside sodium chloride injection and the pelicoside glucose injection: the pelicoside 40 mg, Sodium Chloride 2.25g, made into Pelicoside Sodium Chloride Injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day; Glucoside injection, its specification is 500ml, intravenous injection, 1 bottle each time, once a day.

Embodiment 3

[0104] Example 3: Take 20 g of glucoside prepared by the method of Example 1, add an appropriate amount of water for injection, adjust the pH value to 7 with sodium carbonate, stir and dissolve, and then add an amount equivalent to 10-15% of glucoside Mannitol for injection is sterilized and filtered, its content is determined, and it is packaged in 1000 tubes, 20 mg per tube, sealed, and ready to be obtained. Intravenous injection, 40mg each time, once a day.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to an ilex pedunculosa glycoside for curing cardio-cerebral vascular system diseases of coronary heart disease, angina pectoris, apoplexy and cerebral infarction, medicine composite containing ilex pedunculosa glycoside and its extraction separation method. Said extraction separation method includes the following steps: using ethyl alcohol to extract ilex pedunculosa to obtain extract, adding water into said extract, making centrifugal separation, concentrating supernatant fluid, making centrifugalization, washing precipitate by using proper quantity of water, drying and using ethyl alcohol to make crystallization so as to obtain the ilex pedunculosa glycoside pure product whose content can be up to above 98.0%.

Description

technical field [0001] The invention relates to a medicine for treating diseases of the cardiovascular and cerebrovascular systems, a health food and a preparation method thereof, in particular to the composition of the active ingredient of the traditional Chinese medicine, glucoside, the medicine containing glucoside, and the health food and their corresponding preparation methods. Background technique [0002] Jiubing is the bark of Ilex rotunda Thunb., a plant in the Ilex family Ilex family. It is mainly produced in Guangxi and Guangdong provinces. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. For colds, tonsillitis, sore throat, acute gastroenteritis, rheumatic bone pain; external use for bruises, carbuncle furuncle sores, traumatic bleeding, burns and scalds. The chemical components mainly contain triterpenoid saponins, flavonoid glycosides, phenols, tannins, etc., and the content of saponins is relatively high, abou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/10A61K129/00
Inventor 李超生
Owner 李超生
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap