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Traditional Chinese medicine composition and preparation method thereof

The technology of a composition and a traditional Chinese medicine preparation is applied in the field of traditional Chinese medicine composition and its preparation, which can solve the problems such as the inability to guarantee that the drug effect is not affected, and achieve the effects of facilitating clinical application, reducing the risk of lead poisoning, and avoiding the ingestion of lead.

Active Publication Date: 2013-11-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to reduce the toxic and side effects, if the Mitha monk is removed from the prescription, there is no guarantee that the efficacy of the prescription will not be affected

Method used

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  • Traditional Chinese medicine composition and preparation method thereof
  • Traditional Chinese medicine composition and preparation method thereof
  • Traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Embodiment 1 The preparation of the Chinese medicine composition provided by the present invention

[0082] Take 100g of borneol and crush it into a fine powder, and set aside; take 100g of Coptidis rhizome and crush it into a coarse powder, add 2L of ethanol aqueous solution with a mass fraction of 60%, and reflux extraction for 3 times, each extraction for 3 hours, to obtain the first extract, which is filtered , take the first filtrate, remove ethanol, concentrate to a relative density of 1.30-1.35 (measured at 80°C), and obtain the first extract;

[0083] Take 100g Rhizoma Chuanxiong, 100g Shichangpu, and 100g Curcuma, add 1.6L of water, extract by steam distillation for 10 hours, and obtain the volatile oil and the second extract; take the volatile oil and β-cyclodextrin to obtain the β-cyclodextrin inclusion compound of the volatile oil matter; take the second extract, filter to obtain the second filtrate and dregs;

[0084] Mix the dregs with 100g polygala, 100g...

Embodiment 2

[0087] Embodiment 2 The preparation of the Chinese medicine composition provided by the present invention

[0088] Take 10g of borneol and crush it into a fine powder, and set aside; 40g of Coptidis rhizome is crushed into a coarse powder, add 0.16L (4 times) of ethanol aqueous solution with a mass fraction of 90% by volume, and reflux extraction for 3 times, each extraction for 0.5 hours, to obtain the first extraction After filtering, take the first filtrate, remove ethanol, concentrate to a relative density of 1.30-1.35 (measured at 80°C), and obtain the first extract;

[0089] Take 40g of Rhizoma Chuanxiong, 70g of Shichangpu, and 50g of Curcuma, add 1.6L (10 times) of water, extract by steam distillation for 10 hours, and obtain the volatile oil and the second extract; take the volatile oil and β-cyclodextrin to obtain the β-cyclodextrin of the volatile oil Dextrin inclusion compound; take the second extract, filter to obtain the second filtrate and medicinal residues;

...

Embodiment 3

[0093] Embodiment 3 The preparation of the Chinese medicine composition provided by the present invention

[0094] Take 99g borneol and crush into fine powder, 99g of Coptidis rhizoma into coarse powder, add 0.6L mass fraction of 75% ethanol aqueous solution, reflux extraction 3 times, extract 0.5 hour each time, obtain the first extract, after filtering, take The first filtrate, ethanol removed, concentrated to a relative density of 1.30-1.35 (measured at 80°C), to obtain the first extract;

[0095] Take 1g of Rhizoma Chuanxiong, 99g of Shichangpu, and 99g of Curcuma, add 1.2L of water, extract by steam distillation for 5 hours, and obtain the volatile oil and the second extract; take the volatile oil and β-cyclodextrin to obtain the β-cyclodextrin inclusion compound of the volatile oil matter; take the second extract, filter to obtain the second filtrate and dregs;

[0096] Mix the dregs with 1g polygala, 99g rhubarb, 1g dannanxing, and 99g ground beetle, add 6 times the ma...

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Abstract

The invention relates to the field of a traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following materials in parts by weight: 1-99 parts of rhizoma acori graminei, 1-99 parts of radix curcumae, 1-99 parts of coptis chinensis, 1-99 parts of ligusticum wallichii, 1-99 parts of wined rheum officinale, 1-99 parts of borneol, 1-99 parts of polygala tenuifolia, 1-99 parts of ground beeltle and 1-99 parts of arisaema cum bile. Ingestion of lead in use of medicines is avoided by omitting lithargite used as an adjuvant drug in the traditional prescription; the risk of lead poisoning is reduced. An experiment result shows that compared with the traditional prescription, the traditional Chinese medicine composition provided by the invention does not generate a significant difference on the influence of cerebral injuries of reperfusion rats or animal cerebral blood flow and cerebral vascular resistance; the traditional Chinese medicine composition provided by the invention does not display acute toxicity on the mice by an acute toxicity test.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Stroke, also known as cerebral apoplexy, is a general term for cerebrovascular diseases in traditional Chinese medicine. It is a thrombus formed due to cerebral artery wall damage, changes in blood components, abnormal blood rheology, and hemodynamic changes, resulting in obvious cerebral artery lumens. Stenosis or even occlusion, caused by local brain tissue infarction in the occluded blood vessel supply area, is a type of disease whose main symptoms are hemiplegia with sudden coma, unconsciousness, crooked mouth corners, and poor speech. Due to the high morbidity rate, high mortality rate, high disability rate, high recurrence rate and many complications of this disease, the medical community listed it as one of the three major diseases threatening human health...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P9/10A61P25/00A61P9/12A61K35/64
Inventor 曲晓波邱智东董雪莲朱凯贾爱玲董金香尚昆于智莘
Owner TIANJIN TASLY PHARMA CO LTD
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