Pharmaceutical use of senkyunolide A, and medicinal composition containing it and its prepairng method

A technology of yangchuan xiongolide and composition, which is applied in the pharmaceutical use of yangchuan xiongolide A and the field of pharmaceutical compositions and preparations containing it

Inactive Publication Date: 2007-06-13
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is generally believed that Ligustrazine and volatile oil are the main active ingredients in Ligustrazine, but some scholars have studied Ligustrazine in Ligustra, and found that the content of Ligustrazine in Ligusticum Ligusticum is only a few parts per million, which proves that the medicinal effect of Ligustrazine is closely related to that of Ligustrazine. Irrelevant, it is the role of other ingredients

Method used

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  • Pharmaceutical use of senkyunolide A, and medicinal composition containing it and its prepairng method

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0018] Preparation example 1, prepare Rhizoma Chuanxiong volatile oil

[0019] Preparation method of volatile oil of Rhizoma Chuanxiong: take 100g decoction pieces of Rhizoma Chuanxiong, crush and sieve, follow the determination method of volatile oil in appendix XD of "Chinese Pharmacopoeia" 2000 edition, continue distillation for 2 hours, collect volatile oil, and obtain it.

preparation example 2

[0020] Preparation example 2, preparation of Rhizoma Chuanxiong volatile oil

[0021] The preparation method of the volatile oil of Chuanxiong: Take 500g of Chuanxiong decoction pieces, crush and sieve, put in a 5L supercritical extraction equipment, and carry out CO 2 Supercritical fluid extraction, the extraction pressure is 25MPa, the extraction temperature is 40°C, the extraction time is 4 hours, CO 2 The flow rate is 2L / Kg·h, the extract of Rhizoma Chuanxiong is filtered, the filtrate is allowed to stand still, and the oil layer is taken to obtain the product.

preparation example 3

[0022] Preparation example 3, the preparation method of Ligusticolactone A

[0023] Take 2kg of 200-300 mesh column chromatography silica gel, petroleum ether as solvent, and wet-pack the column; take 200g of Chuanxiong oil, mix the sample with 1:1 silica gel, load the sample, elute with petroleum ether, detect by TLC, and collect Part A of the ester was obtained by recovering the solvent in a rotary thin film evaporator under vacuum at 40°C. The content of chuanxionglide A was 90.2% as measured by the HPLC external standard method.

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Abstract

The present invention provides medicinal application of cnidium officinale lactone A, medicine composition containing said cnidium officinal lactone A and their preparation method. Said cnidium officinal lactone A has the functions of increasing volume of blood flow of brain, reducing vascular resistance of brain and inhibiting thrombosis, so that it can be used for curing cerebrovascular disease.

Description

technical field [0001] The invention relates to the application of senkyunolide A (Senkyunolide A) in the medicine for treating cerebrovascular diseases, and also relates to the preparation method of the intravenous emulsion for injection containing the compound. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases that endanger human life and health. They are characterized by high morbidity, disability, mortality and recurrence. The number of patients with cardiovascular and cerebrovascular diseases in my country is increasing year by year, and the age is getting younger. [0003] Ligusticum chuanxiong is one of the commonly used traditional Chinese medicines for promoting blood circulation and removing blood stasis, which was first recorded in "Shen Nong's Materia Medica". The medicinal part is the rhizome of Ligusticum chuanxiong Hort. [0004] It is generally believed that Ligustrazine and volatile oil a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/00A61P9/10A61P7/02
Inventor 吴巍滕厚雷邵萌刘军锋
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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