Medicine composition of gingko leaf and rhodiola root

A composition, technology of Rhodiola rosea, used in the field of medicine

Inactive Publication Date: 2007-03-21
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, the use of Ginkgo biloba or its extracts, or the total flavonoids of Ginkgo biloba, or the interaction of ginkgolides and Rhodiola rosea or its extracts, and compatible prescriptions to prepare drugs for the treatment of cardiovascular and cerebrovascular diseases has not yet been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0219] Example 1 Preparation and content determination of Ginkgo biloba extract

[0220] Preparation of Ginkgo biloba extract

[0221] Take 5 kg of ginkgo leaves, crush them, add 75% ethanol to reflux and extract twice, add 10 times the amount of alcohol for the first time, extract for 3 hours, add 8 times the amount of alcohol for the second time, extract for 2 hours, combine the filtrates, and concentrate the filtrates to contain alcohol About 5%, add the same amount of water, stir well, refrigerate at 4°C for 24 hours, centrifuge, take the supernatant and put it on the column, wash it with 3 times the volume of water, 15% ethanol, and 75% ethanol, collect the 75% ethanol solution, Concentrate under reduced pressure to 1 / 3 of the volume of the medicinal material, let stand, filter, concentrate the filtrate under reduced pressure, dry in vacuum, and pulverize to obtain.

[0222] Three batches of Ginkgo biloba extract were prepared respectively, and the yields are shown in Ta...

Embodiment 2

[0237] Example 2 Preparation and Content Determination of Ginkgo Leaf Total Flavonoids

[0238] Preparation of total flavonoids from Ginkgo biloba leaves

[0239] Take 1kg of ginkgo leaves, chop them, add 70% ethanol and warm soak at 80°C for two times, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add appropriate amount of water to obtain a suspension equivalent to 1g of the original medicinal material per 1ml , refrigerated for 12 hours, centrifuged, took the supernatant, added to the treated polyamide column (100g, 30-60 mesh, ethanol wet packing, first washed the column with 2 times the column volume of ethanol, and then washed it with water (nearly alcohol smell, spare), first wash with 3 times column volume of water, then wash with 2 times column volume of 10% ethanol, discard the eluent, and wash with 4 times column volume of 80% ethanol eluate, collect eluent, recover ethanol, concentrate under reduced pressure to ...

Embodiment 3

[0249] Embodiment 3 preparation and content determination of ginkgolide

[0250] Preparation of Ginkgolide

[0251] Take 1kg of ginkgo leaves, chop them, add 70% ethanol and warm soak at 80°C for two times, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add appropriate amount of water to obtain a suspension equivalent to 1g of the original medicinal material per 1ml . Add 1 / 2 amount of petroleum ether to shake and extract 4 times, discard the petroleum ether extract; then use 1 / 2 amount of ethyl acetate to shake and extract 4 times, combine the ethyl acetate solution, recover the solvent under reduced pressure, and evaporate to dryness , add 30% ethanol to the residue and heat to dissolve, leave to crystallize, crystallize and recrystallize once with 30% ethanol to obtain the product.

[0252] Three batches of ginkgolides were prepared respectively, and the yields are shown in Table 2-3.

[0253] Content Determination of ...

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparation process and medicine preparation. The medicine composition is prepared with gingko leaf, gingko leaf total flavone or bilobalide, and rhodiola root or its extract. The medicine composition may be prepared into different pharmaceutically acceptable forms, the preparation process is simple and suitable for industrial production, and the preparation has high stability. These two ingredients generate synergistic effects of inhibiting platelet aggregation, antagonizing thrombosis, improving hemodynamics, raise body's immunity, etc.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition for cardiovascular and cerebrovascular diseases, a preparation method thereof, and a preparation containing the pharmaceutical composition, which belong to the field of medicine [0002] technology field. 2. Background technology [0003] In medicine, cardiovascular and cerebrovascular diseases refer to diseases of heart ischemia or hemorrhage caused by hardening of the heart and arteries, including coronary heart disease, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction, etc. Cardiovascular and cerebrovascular diseases have always been known as the number one killer threatening human health. Hypertension, hyperlipidemia, coronary heart disease, and diabetes have become "the plague of the times." According to relevant survey reports, more than 3 million people die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P9/10
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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