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Pharmaceutical composition of melon betel or its extract and safflower or its extract

A technique for cardiovascular and cerebrovascular diseases and compositions, applied in the field of medicine

Inactive Publication Date: 2010-12-15
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of Trichosanthes or Trichosanthes extract and safflower or safflower yellow pigment interaction and compatibility formula to prepare drugs for treating cardiovascular and cerebrovascular diseases

Method used

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  • Pharmaceutical composition of melon betel or its extract and safflower or its extract
  • Pharmaceutical composition of melon betel or its extract and safflower or its extract
  • Pharmaceutical composition of melon betel or its extract and safflower or its extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] Preparation and assay of embodiment 1 Trichosanthes quince extract

[0124] Preparation of Fructus Trichosanthes Extract

[0125] Take Trichosanthes medicinal material, dry, crush into coarse powder, add water to reflux and extract twice, add 10 times the amount of water each time, reflux extract for 2 hours, filter, combine filtrates, concentrate to a relative density of 1.10-1.15 (60°C ) concentrated solution, add ethanol until the alcohol content reaches 80%, leave it overnight, take the supernatant, recover the ethanol until it has no alcohol smell, reduce the pressure to a thick paste, and dry it in vacuum to obtain Trichosanthes extract 1.

[0126] Preparation of Trichosanthes quince extract II

[0127] Take Trichosanthes medicinal material, dry, crush into coarse powder, add water to reflux and extract twice, add 10 times the amount of water each time, reflux extract for 2 hours, filter, combine filtrates, concentrate to a relative density of 1.10-1.15 (60°C ...

Embodiment 2

[0135] The preparation and identification and content determination of embodiment 2 safflower yellow pigment

[0136] Preparation of safflower yellow pigment one

[0137] Take safflower, soak and extract three times at 70°C with acid water with a pH of 3, each time with 50 times the amount of acid water, and each time for 1.5 hours. Combine the extracts, filter, collect the filtrate, let it cool, adjust the pH value to neutral, concentrate under reduced pressure to a relative density of 1.05-1.10, add ethanol until the alcohol concentration is 70%, refrigerate (below 10°C) for 24 hours, filter After that, the filtrate is added to the processed macroporous adsorption resin HPD100 column chromatography (the ratio of medicinal material and resin is 1:10 (W / V)), and the deionized water is used to deionize the water with 1~2.5ml / cm 2 / min flow rate to elute two column bed volumes, and then use 60% ethanol at 1-2.5ml / cm 2 5 column bed volumes were eluted at a flow rate of 60% / min,...

Embodiment 3

[0149] Embodiment 3 Preparation of the pharmaceutical composition aqueous injection of the present invention

[0150] Prescription 1:

[0151] Trichosanthes extract 2 350g (equivalent to 10kg of raw medicinal materials)

[0152] Safflower yellow pigment 1 61g (equivalent to 5kg of original medicinal materials)

[0153] Add water for injection to 5000ml

[0154] A total of 1000 sticks were prepared

[0155] Prescription 2:

[0156] Trichosanthes extract 2 350g (equivalent to 10kg of raw medicinal materials)

[0157] Safflower yellow 2 96.5g (equivalent to 5kg of original medicinal materials)

[0158] Add water for injection to 5000ml

[0159] A total of 1000 sticks were prepared

[0160] Prescription 3:

[0161] Trichosanthes extract 2 35g (equivalent to 1kg of raw medicinal materials)

[0162] Safflower yellow pigment 1 183g (equivalent to 15kg of raw medicinal materials)

[0163] Add wate...

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Abstract

The present invention belongs to medical technique field, a medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation and application thereof and preparation containing the medicinal composition are disclosed. Constitution of raw material medicine containing medicinal components used for preparing the medicinal composition is: fructus trichosanthis 100 to 2000shares, safflower 100 to 1500 shares, or is: fructus trichosanthis extraction 2 to 160 shares, safflower yellow pigment 1 to 45 shares. The medicinal composition can be prepared into various pharmaceutically any acceptable preparations, optimizing injection or oral preparation. The medicinal composition of the present invention has effects such as dilating coronary artery, increasing coronary flow, inhibiting thrombocyte coagulation, decreasing blood viscosity, improving hemorheology and microcirculation, reducing thrombosis, improving heart blood-supplying function, decreasing cerebrovascular resistance, increasing cerebrovascular flow, improving brain microcirculation and etc.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for cardiovascular and cerebrovascular diseases, a preparation method and application thereof, and a preparation containing the pharmaceutical composition. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been known as the No. 1 killer threatening human health and longevity. Among the elderly in China, the incidence rate of cardiovascular and cerebrovascular diseases is as high as 30%. Cardiovascular and cerebrovascular diseases rank first in the cause of death, much higher than the rate of other diseases. With the improvement of people's living standards, the accelerated pace of life, and the development of eating habits towards high fever and high fat, the incidence of the disease is increasing year by year, and it shows a younger trend. However, at present, the development speed of cardiovascul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/428A61P9/00A61K31/351
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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