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Rhodiola root powdery injection and its preparation

A Rhodiola rosea powder injection technology, which is applied in the field of preparation of the large-plant Rhodiola rosea powder injection, can solve the problems of high stability, high bioavailability, restrictions on the application of large-plant Rhodiola rosea, and long medication cycle. Achieve significant anti-myocardial ischemia, significant anti-cerebral ischemia effects, and rapid onset of effect

Inactive Publication Date: 2003-11-19
吴梅春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the Rhodiola rosea preparations clinically used are oral preparations with slow onset and long medication cycle. There is no powder injection with good stability, fast onset, high bioavailability and available for intravenous injection, which limits Further clinical application of Dazhu Rhodiola rosea

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Get 1000g of large rhodiola medicinal material, slice it, use 12 times the amount of 45% ethanol to reflux extract 3 times each time, each time for 1 hour, combine the extracts, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates to relative For a concentrated solution with a density of 1.05 (60°C), add 3 times the amount of water, stir evenly, refrigerate for 72 hours, filter, and concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.08 (60°C), add ethanol to make the The amount reaches 80%, stir well, adjust the pH value to 8.0 with 20% sodium hydroxide solution, refrigerate for 48 hours, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a concentrated solution with a relative density of 1.12 (60°C) to obtain extract, spare;

[0018] (2) Get the above-mentioned extract, flow through the macroporous adsorption resin chromatography column, first elute w...

Embodiment 2

[0021] (1) Get 1000g of large rhodiola medicinal material, slice it, and extract 3 times with 10 times the amount of 65% ethanol at a time, each time for 1 hour, combine the extracts, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates it to a relatively high temperature. For a concentrated solution with a density of 1.08 (60°C), add 4 times the amount of water, stir evenly, refrigerate for 66 hours, filter, and concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.06 (60°C), add ethanol to make the The amount reaches 85%, stir well, adjust the pH value to 8.5 with 30% sodium hydroxide solution, refrigerate for 38 hours, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a concentrated solution with a relative density of 1.13 (60°C) to obtain extract, spare;

[0022] (2) Get the above-mentioned extract, extract it with an equal volume of n-butanol each time, extrac...

Embodiment 3

[0025] (1) Get 1000g of large rhodiola medicinal material, slice it, and extract twice with 12 times of 60% ethanol backflow, each time for 1.5 hours, combine the extracts, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates it to a relatively high temperature. For a concentrated solution with a density of 1.06 (60°C), add 5 times the amount of water, stir evenly, refrigerate for 56 hours, filter, and concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.07 (60°C), add ethanol to make the The amount reaches 85%, stir well, adjust the pH value to 8.5 with 30% sodium hydroxide solution, refrigerate for 48 hours, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a concentrated solution with a relative density of 1.18 (60°C) to obtain extract, spare;

[0026] (2) Take the above extract, after vacuum drying, grind into fine powder, dissolve with 250ml of ethanol, add 1...

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Abstract

A rhodiola powder injection for treating the cardiovascular and cerebrovascular disease such as coronary heart disease, ischemic apoplexy, etc is prepared from rhodiola through extracting, purifying, adding additive, mixing and freeze drying. Its advantages are high curative effect and stability, and long active period.

Description

Technical field [0001] The invention relates to a large-plant rhodiola powder injection, and at the same time, the invention also relates to a preparation method of the large-plant rhodiola powder injection. Background technique [0002] Rhodiola large, also known as Rhodiola narrow leaves, is the dry root and rhizome of Rhodiola kirilowii (Regel.) Maxim. One part of the Pharmacopoeia of the People's Republic of China in 1977 and the Standard of Tibetan Medicine have the effects of promoting blood circulation and stopping bleeding, removing blood stasis and reducing swelling. Folks are used to treat bruises, hematemesis, hemoptysis, and menorrhagia. Pharmacological studies in recent years have shown that Rhodiola grandis has anti-thromboxane formation, anti-myocardial ischemia, anti-virus, anti-radiation, anti-fatigue, anti-aging, improves the aerobic metabolism of hypoxic animals, and enhances the resistance to hypoxic environments. Tolerance and other pharmacological eff...

Claims

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Application Information

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IPC IPC(8): A61K31/7028A61P9/10
Inventor 吴梅春
Owner 吴梅春
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