44 results about "Deoxyschizandrin" patented technology

An extraction method of lignans in schisandra chinensis rattan stems adopts cut or discarded schisandra chinensis rattan stems as raw materials, has low cost, and has low requirements for rattan stem growth years, and rattan stems can be obtained at all seasons, which solve the strict time limit for production, and reduce working strength; various lignans in schisandra chinensis rattan stems are extracted by an ultrasonic processing method; the operation is simple; the extraction efficiency of various lignans in schisandra chinensis rattan stems is high; the mean values of the contents of schisantherin A, deoxyschizandrin, schisandrin B, and schisadrol A extracted from newborn rattan stems are respectively 0.7394%, 0.2229%, 0.1474%, and 0.1237%; the mean values of the contents of schisantherin A, deoxyschizandrin, schisandrin B, and schisadrol A extracted from perennial rattan stems are respectively 1.1901%, 0.4760%, 0.2850%, and 0.1768%; and the product is applicable to industrial production.

The invention relates to the technical field of medicine. The main characteristic components of Schisandra chinensis are lignans, which include schisandrin A, schisandrin B, schisandrin C, etc. Modern pharmacological experiments show that lignans have liver protection and anti-oxidation properties. Various pharmacological activities. The invention provides new medical applications of schisandrin B and schisandrin C components, specifically the application in the preparation of anti-hepatic fibrosis drugs. The pharmacodynamic studies of the present invention show that Schizandrin B and Schisandra C can significantly reduce the concentrations of ALT and AST in the serum of liver fibrosis model rats induced by common bile duct ligation and CCL4, improve the symptoms of liver fibrosis, and have good anti-inflammatory effects. Liver fibrosis activity, so it can be used to prepare anti-hepatic fibrosis medicine or health food.

The invention discloses a method for extracting, separating and preparing lignin monomers from schisandra chinensis. The method comprises the following steps: performing supercritical extraction on schisandra chinensis medicinal powder by using CO2 to obtain a crude extract; performing primary high-speed counter-current chromatographic separation on the crude extract; forming a solvent system A by using hexane, ethyl acetate, methyl alcohol and water in the volume ratio of (2-10):(0-10):(0-10):5, wherein the upper phase A is a stationary phase A and the lower phase A is a mobile phase A; preparing a first schizandrol, a second schizandrol and a third schizandrol; recovering the separated stationary A to serve as a sample to be tested; performing secondary high-speed counter-current chromatographic separation; forming a solvent system B by using hexane, ethyl acetate, methyl alcohol and water in the volume ratio of (1-10):(0-4):(0-9):1, wherein the upper phase B is a stationary phase B, and the lower phase B is a mobile phase B; preparing deoxyschizandrin and schisandrin b. By adopting the method which integrates supercritical extraction and high-speed counter-current chromatographic separation, the deoxyschizandrin and the schisandrin b can be directly used for separating and purifying subsequent monomers without complex sample treatment after the extraction; the steps of extracting and separating are simple and efficient.

The invention discloses applications of deoxyschizandrin in inhibiting growth of multi-drug-resistance escherichia coli. Deoxyschizandrin has good in-vitro killing action on human multi-drug-resistance Escherichia coli resisting ampicillin, nalidixic acid, cefotaxime, ciprofloxacin, cefoxitin and the like, the deoxyschizandrin can inhibit the growth of multi-drug-resistance escherichia coli at theminimum bactericidal concentration of 25.57 microg / mL and minimum inhibitory concentration of 3.13 microg / mL. The invention provides the inhibition of deoxyschizandrin on human multi-drug-resistanceescherichia coli. The deoxyschizandrin can effectively relieve or solve the drug-resistance infection problem of the multi-drug-resistance escherichia coli, reduce the case fatality rate, thus havingimportant practical significance on providing a new concept for inhibiting the human multi-drug-resistance Escherichia coli.