Application of schisandrin in inhibiting the growth of multi-drug resistant Escherichia coli

A technology of schisandrin A and Escherichia coli, applied in the directions of antibacterial drugs, resistance to vector-borne diseases, ether/acetal active ingredients, etc., can solve the bacteriostatic situation of human multidrug-resistant Escherichia coli and other problems, to achieve the effect of solving drug-resistant infections, wide application value, and reducing the mortality rate

Active Publication Date: 2020-03-03
NINGBO MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
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Problems solved by technology

However, the antibacterial effect of Schisandra chinensis extract on human multi-drug resistant Escherichia coli has not been reported yet.

Method used

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  • Application of schisandrin in inhibiting the growth of multi-drug resistant Escherichia coli
  • Application of schisandrin in inhibiting the growth of multi-drug resistant Escherichia coli
  • Application of schisandrin in inhibiting the growth of multi-drug resistant Escherichia coli

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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the content of the present invention, but not to limit the present invention.

[0016] 1. Drug susceptibility test of human pathogenic Escherichia coli

[0017] The present invention uses 10 strains of human Escherichia coli as starting strains, and selects ampicillin, imipenem, nalidixic acid, ciprofloxacin, cefotaxime, azithromycin, gentamicin, ceftazidime, amikacin and cephalosporin The susceptibility test of Xiding 10 commonly used antibiotics was carried out.

[0018] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the plate, and place it at room temperature for 3-5 minutes. Use sterile tweezers to stick drug-sensitive pa...

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Abstract

The invention discloses applications of deoxyschizandrin in inhibiting growth of multi-drug-resistance escherichia coli. Deoxyschizandrin has good in-vitro killing action on human multi-drug-resistance Escherichia coli resisting ampicillin, nalidixic acid, cefotaxime, ciprofloxacin, cefoxitin and the like, the deoxyschizandrin can inhibit the growth of multi-drug-resistance escherichia coli at theminimum bactericidal concentration of 25.57 microg / mL and minimum inhibitory concentration of 3.13 microg / mL. The invention provides the inhibition of deoxyschizandrin on human multi-drug-resistanceescherichia coli. The deoxyschizandrin can effectively relieve or solve the drug-resistance infection problem of the multi-drug-resistance escherichia coli, reduce the case fatality rate, thus havingimportant practical significance on providing a new concept for inhibiting the human multi-drug-resistance Escherichia coli.

Description

technical field [0001] The invention relates to the technical field of application of active ingredients of traditional Chinese medicines, in particular to the application of schisandrin in inhibiting the growth of multidrug-resistant Escherichia coli. Background technique [0002] At present, the global public health field is facing severe challenges. The increasing resistance of bacteria to existing antibiotics and the lack of development of new antibiotics make the treatment of bacterial infectious diseases more and more difficult, and human beings may once again face the dilemma of no available drugs. The emergence of multidrug-resistant bacteria has brought great challenges to clinical treatment. For example, ineffective treatment not only delays the disease, but also consumes social resources and increases the national public financial burden. At the same time, drug-resistant pathogenic bacteria have increased the incidence of infectious diseases and mortality. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61P31/04
CPCA61K31/09Y02A50/30
Inventor 林文凭许国章李永东钱卫东
Owner NINGBO MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
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