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Deoxyschizandrin-containing drug composition and application thereof

A technology of schisandrin A and composition, which is applied in the direction of drug combination, ether/acetal active ingredients, blood diseases, etc., to achieve the effect of preventing platelet aggregation and preventing thrombosis

Pending Publication Date: 2018-10-23
NANHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for its new function of anti-platelet aggregation, it has not been discovered so far.

Method used

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  • Deoxyschizandrin-containing drug composition and application thereof
  • Deoxyschizandrin-containing drug composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Determining the Effect of Schizandrin A on Platelet Aggregation

[0017] The platelet aggregation rate was measured with a platelet aggregation coagulation factor analyzer (LG-PABER-I, Beijing Shidi Scientific Instrument Company). The instrument adopts photoelectric turbidimetry to test platelet aggregation: platelet poor plasma (PPP) is used as the substrate, and platelet rich plasma (PRP) is used for measurement. Under the stirring of the magnetic beads, the inducer is added to the PRP, the platelets aggregate, and the transmittance of the PRP increases or the turbidity decreases. The change of light and turbidity is converted into the change of electrical signal, so as to calculate the aggregation rate of platelets.

[0018] Aggregation rate=(measured voltage value-PPP photoelectric voltage value) / (PRP photoelectric voltage value-PPP photoelectric voltage value)*100%.

[0019] 1. Determination of the effect of different concentrations (0.001, 0.01, 0.1, 1...

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Abstract

The invention relates to a traditional Chinese medicine monomer, i.e. deoxyschizandrin. The traditional Chinese medicine monomer can inhibit the ADP-induced platelet aggregation promotion effect. Theinvention further discloses the fundamental research of deoxyschizandrin as a novel anti-platelet aggregation drug in thrombosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing a traditional Chinese medicine monomer schisandrin and its application, which has the effect of inhibiting platelet aggregation induced by ADP. Background technique [0002] Schisandra chinensis is the dry and mature fruit of the genus Schisandra genus Schisandraceae, a perennial deciduous vine, Magnoliaceae. It has sweet, sour, pungent, bitter, and salty five flavors, so it is called Schisandra. Lignans are the main active ingredients in Schisandra chinensis, including Schisandrin A, Schisandrin B, etc. The research on the pharmacological effects of schisandrin A is very extensive, involving various aspects such as the digestive system, cardiovascular system, central nervous system, reproductive system and urinary system. As for its new function of anti-platelet aggregation, it has not been discovered so far. Platelet aggregation is an important link in the formation of thrombus and th...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61P7/04A61P7/02
CPCA61P7/02A61P7/04A61K31/09Y02A50/30
Inventor 陈临溪陆丽群罗旭灵李瑶李兰芳谢凤
Owner NANHUA UNIV
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