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Method for preparing Chinese medicinal preparation for treating urinary system infection

A technology for urinary system infection and traditional Chinese medicine preparations, which is applied in the field of preparation of traditional Chinese medicine preparations, can solve the problems of losing the active ingredient berberine, unable to fully exert the curative effect and the like, and achieve the effect of diuretic and pain-relieving extraction rate.

Inactive Publication Date: 2009-10-28
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese Patent Announcement No. CN200410015577.6, date of application March 9, 2004, titled "A Traditional Chinese Medicine Oral Preparation for Treating Urinary Tract Infection and Its Preparation Method" discloses the preparation method of the Chinese medicine composition, but this technology also If the method of cooling and filtering is adopted, the active ingredient berberine will also be lost, and the curative effect of the prescription cannot be fully exerted

Method used

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  • Method for preparing Chinese medicinal preparation for treating urinary system infection
  • Method for preparing Chinese medicinal preparation for treating urinary system infection
  • Method for preparing Chinese medicinal preparation for treating urinary system infection

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0025] Experimental Example 1 Study on the extraction method of Angelica dahurica and Schisandra chinensis

[0026] The preparation process of the present invention screens out ethanol solutions of different concentrations as respective extraction solvents according to the difference in fat solubility of the active ingredients of Angelica dahurica and Schisandra chinensis:

[0027] Table 1. Extraction test of imperatorin in Angelica dahurica

[0028]

[0029] It can be seen from the above experimental data that the extraction solvent of imperatorin in Angelica dahurica is preferably 65-75% ethanol solution, and 70% ethanol concentration is the best.

[0030] Table 2. Extraction test of schisandrin in Schisandra chinensis

[0031]

[0032] It can be seen from the above experimental data that the extraction solvent of schisandrin in Schisandra chinensis is preferably an ethanol solution with a concentration of 85-95%, and an ethanol concentration of 90% is the best.

experiment example 2

[0033] Experimental example 2. Research on the extraction method of Cortex Phellodendri

[0034] In the existing preparation of the used prescription of the present invention, the content of berberine is extremely low, and berberine is the main active ingredient of Cortex Phellodendri clearing away heat and dampness, therefore its relevant extraction and separation technology has been carried out following investigation: Take equivalent amount of Cortex Phellodendri 4 The 1st and 2nd portions are added to the other 8 medicinal materials according to the prescription ratio and decocted together.

[0035] Table 3. Extraction test of berberine in Cortex Phellodendri

[0036] serial number

method of extraction

Content determination (mg / g)

1

Add water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, and fry together

solution, let stand for 24 hours, filter

3.52

2

Add water and decoct twice,...

experiment example 3

[0040] Experimental example 3. Pharmacodynamics experiment

[0041] 1 Experimental materials

[0042] 1.1 Drugs

[0043] Test drug group I: the pharmaceutical preparation of the present invention prepared according to Example 5;

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Abstract

The invention relates to a method for preparing a Chinese medicinal preparation for treating urinary system infection. The preparation method takes effective components represented by imperatorin, deoxyschizandrin and berberine as indexes, and determines that angelica dahurica is extracted twice with 70 percent ethanol, 2 hours for the first time and 1.5 hours for the second time; shizandra is extracted twice with 90 percent ethanol, 2 hours for the first time and 1.5 hours for the second time; phellodendron is separately added with water and decocted twice, 2 hours for the first time and 1.5 hours for the second time; and decoction solutions are mixed and filtered when the merged solutions are still hot. The preparation method has the advantage of giving better play to the effect of the prescription in clearing heat, treating stranguria, promoting urination and relieving pain.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation for treating urinary system infection, belonging to the technical field of traditional Chinese medicine. Background technique [0002] "Drug Standards of the Ministry of Health of the People's Republic of China" (Prescriptions of Traditional Chinese Medicine) 17 volumes 148 pages, the standard number is WS3-B-3243-98, and the variety "Urinating Granules" contained in it is made of Bupleurum, Schisandra, It is made of nine traditional Chinese medicines such as storage, Phellodendron Phellodendron, and Angelica dahurica. Its functions and indications are clearing away heat and treating stranguria, diuresis and pain relief, nourishing the kidney and strengthening the foundation. For hot stranguria, red astringent urine pain and urinary tract infection. Its preparation method is: the above nine flavors, decoct twice with water, the first time for 2 hours, the seco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/16A61P13/00
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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