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Application of deoxyschizandrin in preparation of cosmetics or externally-applied medicines with functions of resisting light aging or removing acnes and diminishing inflammation

A total Schisandra, anti-photoaging technology, applied in cosmetics, cosmetic preparations, anti-inflammatory agents, etc., can solve the problems of anti-photoaging, acne and anti-inflammatory reports, etc., to protect skin cells, reduce collagen decomposition, reduce damage effect

Inactive Publication Date: 2015-04-29
SHANGHAI INOHERB COSMETIC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on its anti-photoaging and anti-acne and anti-inflammation aspects

Method used

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  • Application of deoxyschizandrin in preparation of cosmetics or externally-applied medicines with functions of resisting light aging or removing acnes and diminishing inflammation
  • Application of deoxyschizandrin in preparation of cosmetics or externally-applied medicines with functions of resisting light aging or removing acnes and diminishing inflammation
  • Application of deoxyschizandrin in preparation of cosmetics or externally-applied medicines with functions of resisting light aging or removing acnes and diminishing inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 5

[0018] Example 1 Study on Anti-photoaging Effect of Schisandra Fructus Total Elements

[0019] drug:

[0020] Schisandra chinensis, purchased from Harbin Aolin Pharmaceutical Co., Ltd., lignan content > 5% (HPLC)

[0021] Enzyme-linked immunosorbent assay kits for matrix metalloproteinase-1 and glutathione were purchased from Nanjing Jiancheng Bioengineering Institute

[0022] Modified Duchenne Eagle's medium (DMEM medium), fetal bovine serum, purchased from Gibco

[0023] Cell line:

[0024] Dermal fibroblasts were purchased from the American Type Culture Collection.

[0025] Culture conditions: 5% carbon dioxide, cultured in a 37°C incubator. The medium used was modified Duchenne Eagle's medium (DMEM medium), and 10% fetal bovine serum was added, and the bacteria were filtered.

[0026] 1. The effect of Schisandra chinensis on the type I collagen of photodamaged human dermal fibroblasts:

[0027] Cells in the logarithmic growth phase were inoculated on a 24-well cultur...

Embodiment 2 5

[0038] Example 2 Study on the Acne Removing Effect of Schizandra Total Elements

[0039] drug:

[0040] Schisandra chinensis, purchased from Harbin Aolin Pharmaceutical Co., Ltd., lignan content > 5% (HPLC)

[0041] RPMI-1640 medium, fetal bovine serum, purchased from gibco company

[0042] Minced meat medium, dehydrated beef, purchased from Qingdao Rishui Biotechnology Co., Ltd.

[0043] The enzyme-linked immunosorbent assay kits for interleukin-8 and tumor necrosis factor-α were purchased from Shanghai Victall Biological Co., Ltd.

[0044] cell:

[0045] Human acute mononuclear cells were purchased from the Cell Bank of Shanghai Chinese Academy of Sciences

[0046] Culture conditions: 5% carbon dioxide, cultured in a 37°C incubator. The medium used was RPMI-1640 medium, and 10% fetal bovine serum was added, and the filter was sterilized

[0047] Propionibacterium acnes, purchased from Shanghai Fuxiang Biological Co., Ltd.

[0048] Culture conditions: cultured in mince...

Embodiment 3

[0054] Example 3 Safety research on Schisandra chinensis

[0055] drug:

[0056] Schisandra chinensis, purchased from Harbin Aolin Pharmaceutical Co., Ltd., lignan content > 5% (HPLC)

[0057] RPMI-1640 medium, DMEM medium, fetal bovine serum, purchased from gibco company

[0058] cell:

[0059] Human acute mononuclear cells were purchased from the Cell Bank of Shanghai Chinese Academy of Sciences

[0060] Human dermal fibroblasts were purchased from the American Type Culture Collection

[0061] Culture conditions: 5% carbon dioxide, cultured in a 37°C incubator. The medium used was RPMI-1640 or DMEM medium, and 10% fetal bovine serum was added, and the bacteria were filtered.

[0062] Thiazolan (MTT) method was used to detect the effect of the test substance on the proliferation of human monocytes and human dermal fibroblasts, so as to indirectly detect whether Schisandra chinensis was safe for the skin.

[0063] Take the cells in the exponential growth phase, and adjus...

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Abstract

The invention relates to an application of deoxyschizandrin in preparation of cosmetics or externally-applied medicines with functions of resisting light aging or removing acnes and diminishing inflammation. The mass content of Chinese magnoliavine fruit lignan in deoxyschizandrin is not less than 5%, and the use amount of deoxyschizandrin in the cosmetics or the externally-applied medicines is 0.01-10% in percentage by mass. The application disclosed by the invention has the advantages that researches show that deoxyschizandrin has relatively good anti-light-aging effects, also has a relatively good anti-inflammatory effect on inflammation caused by propionibacterium acne, and can be used for preparing the cosmetics or the externally-applied medicines with the effects of resisting light aging or removing the acnes and diminishing inflammation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extracts, in particular to a new application of Schisandra chinensis extract. Background technique [0002] With the continuous destruction of the atmospheric ozone layer, the irradiation of ultraviolet rays from the sun is also increasing accordingly, which has a greater impact on people's life and work. Long-term exposure to ultraviolet rays directly leads to skin photoaging. Skin photoaging is not only detrimental to human beauty, but also has an etiological connection with the occurrence of skin cancer. Therefore, preventing and delaying skin photoaging has become one of the hot spots in medical science, especially aesthetic medicine research. The research on the mechanism of skin photoaging caused by ultraviolet radiation mainly focuses on three aspects: causing the degradation of elasticity-related substances in the extracellular matrix; causing skin oxidative stress; t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K36/79A61K36/57A61Q19/08A61P17/00A61P17/10A61P29/00
Inventor 赵鑫胡国胜卢艳花郭苗苗路越
Owner SHANGHAI INOHERB COSMETIC
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