Application of fructus schisandrae sphenantherae extract in preparation of liver regeneration medicine
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of Schisandra chinensis and extract, which is applied in the field of medicine, can solve problems such as the promotion of liver regeneration by extracts of Schisandra chinensis, improve inflammation infiltration and cell edema, promote liver cell proliferation, and accelerate the recovery of liver weight and function Effect
Active Publication Date: 2016-04-06
SUN YAT SEN UNIV
View PDF1 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, there are no relevant reports on the promotion of liver regeneration after hepatectomy with Schisandra chinensis extract.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0048] The preparation of embodiment 1 southern schisandra extract
[0049] Take 100g of Schisandra chinensis, add 8 times the amount of water to decoct for 1 hour, filter to remove the filtrate, dry the dregs and crush them, use 8 times the amount of 70% ethanol to reflux extract twice, each time for 1.5h, filter, combine the filtrate, and concentrate , that is, the southern Schisandra extract extract.
Embodiment 2
[0050] The preparation of embodiment 2 southern schisandra extract
[0051]Take 100g of Schisandra chinensis, add 6 times the amount of water to decoct for 0.5h, filter to remove the filtrate, dry the dregs and crush them, reflux extract with 6 times the amount of 70% ethanol twice, each time for 1h, filter, combine the filtrate, and concentrate , that is, the southern Schisandra extract extract.
Embodiment 3
[0052] The preparation of embodiment 3 southern schisandra extract
[0053] Take 100g of Schisandra chinensis, add 10 times the amount of water to decoct for 2 hours, filter to remove the filtrate, dry the dregs and crush them, reflux extract with 10 times the amount of 70% ethanol for 3 times, each time for 2 hours, filter, combine the filtrates, concentrate, That is to get the southern Schisandra extract extract.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses application of a fructus schisandrae sphenantherae extract in preparation of a liver regeneration medicine. The fructus schisandrae sphenantherae extract is an alcohol extract of dried fruits of schisandrae sphenantherae, and the main effective ingredients of the fructus schisandrae sphenantherae extract comprise schisantherin and deoxyschizandrin. A partial hepatectomy mouse model is utilized, the fructus schisandrae sphenantherae extract is cooperatively applied, a result shows that the fructus schisandrae sphenantherae extract has the characteristics of being capable of significantly improving the quick recovering capacity of the liver-weight ratio and improving the quick proliferation capacity of liver cells, the mechanism relates to significant activation of protein expression of a related cell cycle, the manifestation is that cyclin D1 and PCNA proteins are significantly up-regulated, and meanwhile obvious improvement on liver tissue inflammatory infiltration and liver cell swelling is achieved. Experimental results show that the fructus schisandrae sphenantherae extract supplies a novel method and treatment means to liver regeneration after hepatectomy.
Description
technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to the application of the extract of Schisandra chinensis in the preparation of liver regeneration medicine. Background technique [0002] Liver resection and living donor liver transplantation are currently the most effective treatments for liver cancer and end-stage liver disease worldwide. The reason why liver resection and living donor liver transplantation are feasible in clinical application is the unique and powerful regenerative ability of hepatocytes. However, after patients undergo surgery, if the remaining liver lacks regeneration ability, delays regeneration ability, or has weak regeneration ability, it will cause a variety of adverse syndromes, such as acute liver failure after surgery, septic infection, ascites, hemorrhage, renal failure or liver failure. encephalopathy. Among them, acute liver failure after surgery is still the main cause of postop...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more