Method for measuring content of Shenqi blood sugar reducing preparation and application thereof in overall quality control

A technology of Shenqi lowering blood sugar and determination method, which is applied in the field of drug quality control, can solve the problems of not reflecting the quality level of compound preparations, reagents pollute the environment, and poor selectivity, and achieve scientific and comprehensive internal quality, high quantitative accuracy of mass spectrometry, and good quality. The effect of quality level
CN106526002AActive Publication Date: 2017-03-22ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2017-03-22

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Abstract

The invention provides a method for measuring the content of a Shenqi blood sugar reducing preparation. The method is used for measuring the content of 10 active ingredients in the Shenqi blood sugar reducing preparation: ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd, ginsenoside Rg1, ginsenoside Re, astragaloside, deoxyschizandrin, schisandrol A, schisandrol B. In the invention, with the guidance of blood sugar reducing activity of a compound, multiple active substances in the compound are detected, and the quality level of the whole compound preparation can be reflected better; meanwhile, a Q-MS ion monitoring mode is selected for content measurement, and the mass spectrum quantification has high accuracy, specificity and sensitivity and is superior to traditional HPLC analysis method; and moreover, fingerprint is established according to the liquid phase diagrams of different batches of Shenqi blood sugar reducing preparations obtained by the method, the similarity is evaluated, the inherent quality of the Shenqi blood sugar reducing preparation product is evaluated more scientifically and comprehensively, and a basis is provided for establishing a quality standard of higher level.
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Description

[0001] (1) Technical field

[0002] The invention belongs to the field of drug quality control, and in particular relates to a method for determining the multi-component content of Shenqi hypoglycemic preparations by high performance liquid chromatography-single quadrupole mass spectrometry (HPLC-Q-MS), and to the method obtained by the method. The construction of fingerprints from liquid chromatograms of Shenqi hypoglycemic preparations also involves the application of this method in the overall quality control of Shenqi hypoglycemic preparations.

[0003] (2) Background technology

[0004] Diabetes Mellitus (DM) belongs to the category of "Diabetes Mellitus" in traditional Chinese medicine: "Those who are thirsty and drink a lot of water, urinate frequently, and are fat-free and sweet like bran are all Diabetes Diseases." The International Diabetes Federation (IDF) pointed out that there are currently 415 million adult diabetic patients in the world, and 318 million people ar...

Claims

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