Application of schisandra chinensis monomer compound in preparation of drugs for prevention and treatment of hepatotoxicity caused by acetaminophen

Abstract

The invention discloses an application of a schisandra chinensis monomer compound in preparation of drugs for prevention and treatment of hepatotoxicity caused by acetaminophen (APAP), wherein the schisandra chinensis monomer compound is deoxyschizandrin, schisandrin C, schisandrin or schisantherin a. Experiment results show that: with the schisandra chinensis monomer compound, the ALT content and the AST content in the APAP-induced liver injury animal model can be significantly reduced, consumption of glutathione in liver cells can be inhibited, the liver cell necrosis degree can be effectively improved, and the schisandra chinensis monomer compound provides significant treatment and protection effects for hepatotoxicity symptoms caused by APAP.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Schisandra chinensis monomer compounds in the preparation of drugs for preventing and treating hepatotoxicity caused by paracetamol. Background technique [0002] Schisandra chinensis is the mature fruit of the perennial deciduous vine of Magnoliaceae, which is divided into northern Schisandra chinensis (Turcz.) baill and southern Schisandra sphenanthera Rehd.et Wils. Schisandra chinensis is rich in lignans, triterpenes, sesquiterpenes, organic acids, volatile oils and polysaccharides, etc. Among them, lignans are beneficial to the human body in many ways, and their application scope and development prospects are getting more and more popular focus on. As a traditional Chinese medicine, Schisandra has the functions of nourishing qi and promoting body fluid, astringing the lungs and nourishing the kidneys, relieving diarrhea, astringent essence, and calming...

AI Technical Summary

Problems solved by technology

[0004] N-acetylcysteine ​​(NAC) is currently a classic drug used clinically for the treatment of acute APAP poisoning, but the limitation of this drug is that its therapeutic window is narrow, and it is ineffective for the treatment of the acute late stage of APAP poisoning, and long-term administration High-dose NAC can interfere with mitochondrial metabolism in normal hepatocytes, block NF-kB signaling pathway and inhibit liver regeneration after APAP liver injury

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