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Chinese magnoliavine active extract

A technology of Schisandra chinensis and extract, applied in ether separation/purification, ether preparation, organic chemistry and other directions, can solve the problems of low content and transfer rate of lignans, unsuitable for industrial production, unreliable extraction method, etc. To achieve the effect of improving polarity, protecting activity and improving extraction rate

Inactive Publication Date: 2017-12-26
浦江县美泽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many documents have reported the extraction process of Schisandra lignans, some of them use organic solvents for extraction, which is not suitable for industrial production; some extraction methods are unreliable, and the content and transfer rate of lignans in the extract Low, causing waste of resources and affecting clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Schisandra active extracts, including schisandrin A, schisandrin A and schisandrin B.

[0018] The preparation method of the active extract of schisandra chinensis comprises reflux extraction, concentrated water precipitation, adsorption, elution and drying. The reflux extraction step is to add 6-9 times the volume of 85-95% ethanol to the schisandra powder and reflux extraction for 1-4 times, and the time for each reflux extraction is 100-150 minutes. The active substance of Schisandra chinensis is extracted by using cheap ethanol solution, which can reduce the production cost and is suitable for industrial production; the production process of the present invention is simple, each step of operation has accurate data, good reproducibility, and stable product quality; ethanol has low toxicity and can be extracted to obtain The active substances of Schisandra chinensis are highly safe, green and safe.

[0019] The concentrated water precipitation step is to concentrate ...

Embodiment 2

[0025] Schisandra active extracts, including schisandrin A, schisandrin A and schisandrin B.

[0026] The most preferred preparation method of Schisandra active extract comprises the following steps:

[0027] 1) Reflux extraction: Add 8 times the volume of 95% ethanol to Schisandra chinensis powder for reflux extraction twice, and the time for each reflux extraction is 120 minutes;

[0028] 2) Concentrated water sedimentation: Concentrate at 10°C and 2KPa for 6 hours, add pure water 5 times the volume of Schisandra powder, let stand at 2°C under normal pressure for 4 hours for water sedimentation, and centrifuge at high speed for the first time;

[0029] 3) Adsorption: Add 20% of the weight of Schisandra powder to the supernatant obtained in the concentrated water sinking step, stir and adsorb for 1 hour, take the activated carbon by high-speed centrifugation for the second time, add 95% ethanol to the activated carbon, and the amount added is the weight of Schisandra powder ...

Embodiment 3

[0032] Schisandra active extracts, including schisandrin A, schisandrin A and schisandrin B.

[0033] The preparation method of Schizandra active extract comprises the following steps:

[0034] 1) Reflux extraction: Add 7 times the volume of 90% ethanol to Schisandra chinensis powder for reflux extraction for 3 times, each time for reflux extraction for 100 minutes;

[0035] 2) Concentrated water sedimentation: Concentrate at 10°C and 2KPa for 6 hours, add pure water 5 times the volume of Schisandra powder, let stand at 2°C under normal pressure for 4 hours for water sedimentation, and centrifuge at high speed for the first time;

[0036] 3) Adsorption: Add 20% of the weight of Schisandra powder to the supernatant obtained in the concentrated water sinking step, stir and adsorb for 1 hour, take the activated carbon by high-speed centrifugation for the second time, add 90% ethanol to the activated carbon, and the amount added is the weight of Schisandra powder 12 times, the so...

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PUM

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Abstract

The invention discloses a Chinese magnoliavine active extract, which comprises schisandrin, deoxyschizandrin, and schisandrin B. The preparation method comprises reflux extraction, concentration and water precipitation, adsorption, elution, and drying. Ethanol (85-95%) is used to extract the Chinese magnoliavine active substances through reflux extraction; then the active substances are purified by water precipitation, adsorption, macroporous resin elution, and reversed-phase high-performance liquid chromatography to obtain schisandrin, deoxyschizandrin, and schisandrin B, and the product quality is high. The production technology is simple, each operation has accurate data, the repeatability is good, the product quality is stable, ethanol is low in toxicity, and the extracted Chinese magnoliavine active substances are very safe and green.

Description

technical field [0001] The invention relates to the field of extraction of plant active substances, in particular to active extracts of schisandra chinensis. Background technique [0002] Schisandra chinensis, first recorded in "Shen Nong's Materia Medica", listed as top grade, is the dried and mature fruit of Magnolia plant Schisandra chinensis, which has the effects of astringent and astringent, nourishing qi and promoting body fluid, nourishing kidney and calming heart, etc. It is mainly produced in Liaoning, Heilongjiang, Jilin and other places . Studies have shown that Schisandra mainly contains lignans, which have the functions of protecting the liver, reducing enzymes, anti-oxidation, anti-tumor, anti-virus, lowering blood pressure, and regulating immunity. It is used to treat the digestive system, cardiovascular system, central nervous system, and reproductive system. and diseases of the urinary system. In view of its exact pharmacological effects, Schisandra is wi...

Claims

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Application Information

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IPC IPC(8): C07C41/34C07C41/36C07C41/40C07C43/23C07C43/21C07D317/70
CPCC07C41/34C07C41/36C07C41/40C07C43/21C07C43/23C07D317/70
Inventor 谢雨欣
Owner 浦江县美泽生物科技有限公司
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