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NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and preparation method and application thereof

A composition and technology of beneficial bacteria, applied in the field of biomedicine, can solve the problems of inability to achieve long-term good absorption of NMN, unscientific expansion of NMN, and unclear side effects, so as to improve intestinal absorption efficiency, improve physiological effects, and have better effects. good effect

Pending Publication Date: 2020-12-18
成都及禾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is an unscientific expansion of the application of NMN. Although most NMN-related products have achieved certain effects through the recommendation of taking large doses, it is impossible to achieve long-term good absorption of NMN and adequate absorption of NMN alone. exert its physiological function
At the same time, the effect of NMN on cell repair, etc., is lack of targeting; and any possible side effects of larger doses of NMN on the human body are not clear

Method used

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  • NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and preparation method and application thereof
  • NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and preparation method and application thereof
  • NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Prepare several groups of NMN beneficial bacteria health compositions: weigh 30 parts of NMN, 13 parts of beneficial bacteria powder, 4 parts of betaine, 3 parts of grape seed extract, 3 parts of baicalein, 3 parts of apigenin, and astaxanthin 3 parts of ginsenosides, 4 parts of ginsenosides and 4 parts of Lingzhi polysaccharide; the beneficial bacteria powder includes by weight parts: 1.5 parts of Bacillus subtilis, 2.5 parts of Bifidobacterium lactis, 1.5 parts of Lactobacillus fermentum, 1 part of Lactobacillus acidophilus , 1 part of Lactobacillus rhamnosus, 1 part of Lactobacillus reuteri, 1 part of Lactobacillus casei, 1 part of Bifidobacterium breve and 1 part of Bifidobacterium animalis;

[0039] 2) Then mix under clean and aseptic conditions, add pure water below 25°C to dissolve, concentrate at a temperature below 25°C, dehydrate and compound to form a healthy composition of NMN beneficial bacteria.

Embodiment 2

[0041] 1) Prepare several groups of NMN beneficial bacteria health compositions: weigh 30 parts of NMN, 15 parts of beneficial bacteria powder, 4 parts of betaine, 3 parts of grape seed extract, 4 parts of ginsenoside, 4 parts of Lingzhi polysaccharide, tryptamine 6 parts of acid, 6 parts of tyrosine, and 3 parts of nicotinamide; the beneficial bacteria powder includes by weight parts: 1.5 parts of Bacillus subtilis, 2.5 parts of Bifidobacterium lactis, 1.5 parts of Lactobacillus fermentum, 1 part of Lactobacillus helveticus , 1 part of Lactobacillus delbrueckii, 1 part of Lactobacillus paracasei, 1 part of Lactobacillus plantarum, 1 part of Bifidobacterium adolescent and 1 part of Bifidobacterium bifidum;

[0042] 2) Then mix under clean and aseptic conditions, add pure water below 25°C to dissolve, concentrate at a temperature below 25°C, dehydrate and compound to form a healthy composition of NMN beneficial bacteria.

Embodiment 3

[0044] 1) Prepare several groups of NMN beneficial bacteria health compositions: weigh 30 parts of NMN, 10 parts of beneficial bacteria powder, 6 parts of betaine, 5 parts of grape seed extract, 3 parts of baicalein, 3 parts of apigenin, astaxanthin 5 parts of prime, 5 parts of tryptophan, 5 parts of tyrosine, 1.5 parts of nicotinamide, 2.5 parts of Panax notoginseng, 2.5 parts of Zhiyuan, 2.5 parts of nepeta, 3.5 parts of licorice, 3.5 parts of sealwort, 2.5 parts of saponins, dendrobium 2.5 parts, 3.5 parts of Acanthopanax and 2.5 parts of Nocturna; the beneficial bacteria powder includes in parts by weight: 1.5 parts of Bacillus subtilis, 2.5 parts of Bifidobacterium lactis, 1.5 parts of Lactobacillus fermentum, and 1 part of Lactobacillus gasseri , 1 part of Lactobacillus jansneri, 1 part of Lactobacillus crispatus, 1 part of Lactobacillus brevis, 1 part of Bifidobacterium infantis, 1 part of Bifidobacterium pseudolongum and 1 part of Bifidobacterium thermophilic acidic a...

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Abstract

The invention relates to the technical field of biological medicine, and discloses an NMN (Beta-Nicotinamide Mononucleotide) beneficial bacterium health composition and a preparation method and application thereof. The composition comprises in parts by weight: 20 to 40 parts of NMN, 10 to 15 parts of beneficial bacterium powder, 0 to 8 parts of betaine, 0 to 5 parts of grape seed extract, 0 to 5 parts of baicalein, 0 to 5 parts of apigenin, 0 to 8 parts of astaxanthin, 0 to 8 parts of ginsenoside, and 0 to 8 parts of ganoderma lucidum polysaccharide (GLP); beneficial bacteria in the NMN beneficial bacterium health composition prepared by the invention can effectively improve the microecology of intestinal floras of a user, not only can improve the metabolic syndrome caused by the intestinal floras of the user, but also can improve the intestinal absorption efficiency, and is beneficial to the absorption of the NMN in the intestinal tract; the ginsenoside and the GLP are mainly matchedto improve the immunity of the user, so that the user can better adapt to various changes of the metabolic pathway level, which are caused by the case that the NAD + level is improved after the NMN enters the human body, and the organism has higher buffering capacity on the changes; and AMPK activators (the betaine, the baicalein and the apigenin) have a synergistic effect with the NMN, so that the NMN beneficial bacterium health composition is better in effect and has no side effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a health composition of NMN beneficial bacteria and its preparation method and application. Background technique [0002] β-nicotinamide mononucleotide, English name: Beta-Nicotinamide Mononucleotide; Abbreviation: NMN; Molecular formula: C 11 h 15 N 2 o 8 P; molecular weight: 334.22. NMN is a substance that already exists in the human body and has important physiological functions for human cells. It is NAD + (Coenzyme I) Synthesis of NAD in the Salvage Synthetic Pathway + It can be derived from a variety of foods, including broccoli, cabbage, cucumber, edamame, avocado, etc., but the content is very low, which cannot achieve the purpose of effective exogenous supplementation. NMN is the synthetic NAD in the human body + The precursor of NAD, its physiological function is mainly through increasing NAD + level to achieve. NAD + The full name of nicotinamide adenine ...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61K36/8984A61P37/04A61P35/00A61P9/12A61P3/10A61P3/06A61P3/04A61P3/02A61P9/00A23L33/13A23L33/135A23L33/105A23L33/125A61K31/122A61K31/205A61K31/352A61K31/375A61K31/4415A61K31/51A61K31/525A61K31/704A61K31/714A61K31/715A61K35/742A61K35/745A61K35/747A61K31/706
CPCA23V2002/00A61K31/122A61K31/205A61K31/352A61K31/375A61K31/4415A61K31/51A61K31/525A61K31/704A61K31/706A61K31/714A61K31/715A61K35/742A61K35/745A61K35/747A61K36/254A61K36/258A61K36/483A61K36/484A61K36/538A61K36/69A61K36/704A61K36/87A61K36/8969A61K36/8984A23L33/105A23L33/125A23L33/13A23L33/135A61P3/02A61P3/04A61P3/06A61P3/10A61P9/00A61P9/12A61P35/00A61P37/04A61K2300/00A23V2200/3204A23V2200/324A23V2250/21166A23V2250/21A23V2250/202A23V2250/2124A23V2250/51A23V2250/302A23V2250/065A23V2250/0652A23V2250/7046A23V2250/708A23V2250/7042A23V2250/7044A23V2250/7052A23V2250/706
Inventor 秦小波
Owner 成都及禾生物科技有限公司
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